Beyond knockouts: cre resources for conditional mutagenesis

• Published in: Mammalian genome Vol. 23; no. 9-10; pp. 587 - 599
• Main Authors: Murray, Stephen A, Eppig, Janan T, Smedley, Damian, Simpson, Elizabeth M, Rosenthal, Nadia
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.10.2012; Springer Nature B.V
• Subjects: Animal Genetics and Genomics; Animals; Biomedical and Life Sciences; Cell Biology; experimental design; Genomics; Human Genetics; Indexing in process; Integrases - genetics; Life Sciences; Mice; Mice, Knockout - genetics; Mutagenesis; phenotype; International Mouse Phenotyping Consortium; International Knockout Mouse Consortium; Mouse Genome Informatics; Embryonic Stem Cell Line; Public Repository

With the effort of the International Phenotyping Consortium to produce thousands of strains with conditional potential gathering steam, there is growing recognition that it must be supported by a rich toolbox of cre driver strains. The approaches to build cre strains have evolved in both sophisticat...