Beyond knockouts: cre resources for conditional mutagenesis

With the effort of the International Phenotyping Consortium to produce thousands of strains with conditional potential gathering steam, there is growing recognition that it must be supported by a rich toolbox of cre driver strains. The approaches to build cre strains have evolved in both sophisticat...

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Published in	Mammalian genome Vol. 23; no. 9-10; pp. 587 - 599
Main Authors	Murray, Stephen A, Eppig, Janan T, Smedley, Damian, Simpson, Elizabeth M, Rosenthal, Nadia
Format	Journal Article
Language	English
Published	New York Springer-Verlag 01.10.2012 Springer Nature B.V
Subjects	Animal Genetics and Genomics Animals Biomedical and Life Sciences Cell Biology experimental design Genomics Human Genetics Indexing in process Integrases - genetics Life Sciences Mice Mice, Knockout - genetics Mutagenesis phenotype International Mouse Phenotyping Consortium International Knockout Mouse Consortium Mouse Genome Informatics Embryonic Stem Cell Line Public Repository
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Abstract	With the effort of the International Phenotyping Consortium to produce thousands of strains with conditional potential gathering steam, there is growing recognition that it must be supported by a rich toolbox of cre driver strains. The approaches to build cre strains have evolved in both sophistication and reliability, replacing first-generation strains with tools that can target individual cell populations with incredible precision and specificity. The modest set of cre drivers generated by individual labs over the past 15+ years is now growing rapidly, thanks to a number of large-scale projects to produce new cre strains for the community. The power of this growing resource, however, depends upon the proper deep characterization of strain function, as even the best designed strain can display a variety of undesirable features that must be considered in experimental design. This must be coupled with the parallel development of informatics tools to provide functional data to the user and facilitated access to the strains through public repositories. We discuss the current progress on all of these fronts and the challenges that remain to ensure the scientific community can capitalize on the tremendous number of mouse resources at their disposal.
AbstractList	With the effort of the International Phenotyping Consortium (IMPC) to produce thousands of strains with conditional potential gathering steam, there is growing recognition that it must be supported by a rich toolbox of cre driver strains. The approaches to build cre strains have evolved in both sophistication and reliability, replacing first generation strains with tools that can target individual cell populations with incredible precision and specificity. The modest set of cre drivers generated by individual labs over the past 15+ years is now growing rapidly, thanks to a number of large-scale projects to produce new cre strains for the community. The power of this growing resource, however, depends upon the proper deep characterization of strain function, as even the best designed strain can display a variety of undesirable features that must be considered in experimental design. This must be coupled with the parallel development of informatics tools to provide functional data to the user, and facilitated access to the strains through public repositories. We will discuss the current progress on all of these fronts and the challenges that remain to ensure the scientific community can capitalize on the tremendous number of mouse resources at their disposal. With the effort of the International Phenotyping Consortium to produce thousands of strains with conditional potential gathering steam, there is growing recognition that it must be supported by a rich toolbox of cre driver strains. The approaches to build cre strains have evolved in both sophistication and reliability, replacing first-generation strains with tools that can target individual cell populations with incredible precision and specificity. The modest set of cre drivers generated by individual labs over the past 15+ years is now growing rapidly, thanks to a number of large-scale projects to produce new cre strains for the community. The power of this growing resource, however, depends upon the proper deep characterization of strain function, as even the best designed strain can display a variety of undesirable features that must be considered in experimental design. This must be coupled with the parallel development of informatics tools to provide functional data to the user and facilitated access to the strains through public repositories. We discuss the current progress on all of these fronts and the challenges that remain to ensure the scientific community can capitalize on the tremendous number of mouse resources at their disposal. With the effort of the International Phenotyping Consortium to produce thousands of strains with conditional potential gathering steam, there is growing recognition that it must be supported by a rich toolbox of cre driver strains. The approaches to build cre strains have evolved in both sophistication and reliability, replacing first-generation strains with tools that can target individual cell populations with incredible precision and specificity. The modest set of cre drivers generated by individual labs over the past 15+ years is now growing rapidly, thanks to a number of large-scale projects to produce new cre strains for the community. The power of this growing resource, however, depends upon the proper deep characterization of strain function, as even the best designed strain can display a variety of undesirable features that must be considered in experimental design. This must be coupled with the parallel development of informatics tools to provide functional data to the user and facilitated access to the strains through public repositories. We discuss the current progress on all of these fronts and the challenges that remain to ensure the scientific community can capitalize on the tremendous number of mouse resources at their disposal. Issue Title: Special Issue: Mouse Genomic Programs and Resources With the effort of the International Phenotyping Consortium to produce thousands of strains with conditional potential gathering steam, there is growing recognition that it must be supported by a rich toolbox of cre driver strains. The approaches to build cre strains have evolved in both sophistication and reliability, replacing first-generation strains with tools that can target individual cell populations with incredible precision and specificity. The modest set of cre drivers generated by individual labs over the past 15+ years is now growing rapidly, thanks to a number of large-scale projects to produce new cre strains for the community. The power of this growing resource, however, depends upon the proper deep characterization of strain function, as even the best designed strain can display a variety of undesirable features that must be considered in experimental design. This must be coupled with the parallel development of informatics tools to provide functional data to the user and facilitated access to the strains through public repositories. We discuss the current progress on all of these fronts and the challenges that remain to ensure the scientific community can capitalize on the tremendous number of mouse resources at their disposal.[PUBLICATION ABSTRACT] Erratum DOI: 10.1007/s00335-012-9434-y
Author	Murray, Stephen A Rosenthal, Nadia Eppig, Janan T Smedley, Damian Simpson, Elizabeth M
AuthorAffiliation	1 The Jackson Laboratory, Bar Harbor, Maine 04609, USA 2 The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK 3 Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute, Departments of Medical Genetics and Psychiatry, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada 4 National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK 5 EMBL Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, Vic 3800, Australia
AuthorAffiliation_xml	– name: 2 The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK – name: 4 National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK – name: 5 EMBL Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, Vic 3800, Australia – name: 3 Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute, Departments of Medical Genetics and Psychiatry, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada – name: 1 The Jackson Laboratory, Bar Harbor, Maine 04609, USA
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Snippet	With the effort of the International Phenotyping Consortium to produce thousands of strains with conditional potential gathering steam, there is growing... Issue Title: Special Issue: Mouse Genomic Programs and Resources With the effort of the International Phenotyping Consortium to produce thousands of strains... With the effort of the International Phenotyping Consortium (IMPC) to produce thousands of strains with conditional potential gathering steam, there is growing...
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SubjectTerms	Animal Genetics and Genomics Animals Biomedical and Life Sciences Cell Biology experimental design Genomics Human Genetics Indexing in process Integrases - genetics Life Sciences Mice Mice, Knockout - genetics Mutagenesis phenotype
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Title	Beyond knockouts: cre resources for conditional mutagenesis
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