Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa

• Published in: Journal of neuroinflammation Vol. 14; no. 1; p. 39
• Main Authors: Hopp, Sarah, Nolte, Marc W, Stetter, Christian, Kleinschnitz, Christoph, Sirén, Anna-Leena, Albert-Weissenberger, Christiane
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.02.2017; BioMed Central; BMC
• Subjects: Animals; Blood coagulation factors; Bradykinin - secretion; Brain; Brain edema; Brain Edema - metabolism; Brain Edema - prevention & control; Brain Injuries - metabolism; Brain Injuries - prevention & control; Brain Injuries, Traumatic - metabolism; Brain Injuries, Traumatic - prevention & control; Cerebral edema; Factor XII; Factor XIIa - antagonists & inhibitors; Factor XIIa - genetics; Factor XIIa - metabolism; Focal brain lesion; Inflammation; Inflammation - metabolism; Inflammation - prevention & control; Influence; Injuries; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Factor XII; Brain edema; Focal brain lesion

Traumatic brain injury (TBI) is a devastating neurological condition and a frequent cause of permanent disability. Posttraumatic inflammation and brain edema formation, two pathological key events contributing to secondary brain injury, are mediated by the contact-kinin system. Activation of this pa...