Acute illness from Campylobacter jejuni may require high doses while infection occurs at low doses

• Published in: Epidemics Vol. 24; pp. 1 - 20
• Main Authors: Teunis, Peter F.M., Bonačić Marinović, Axel, Tribble, David R., Porter, Chad K., Swart, Arno
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2018; Elsevier
• Subjects: Acute Disease; Animals; Campylobacter Infections - epidemiology; Campylobacter Infections - pathology; Campylobacter jejuni; Campylobacter jejuni - pathogenicity; Challenge studies; Disease Outbreaks - statistics & numerical data; Hierarchical dose response; Humans; Infectivity; Natural experiments; Natural experiments; Hierarchical dose response; Infectivity; Challenge studies; Campylobacter jejuni

•This study generalizes infection and illness dose response relations for Campylobacter jejuni, accounting for variation in pathogen (strain) and host (immunity, species) characteristics.•Susceptibility to infection likely is high, requiring small doses to colonize.•In outbreaks illness occurs at lo...