Structural basis for gating the high-conductance Ca2+-activated K+ channel

• Published in: Nature (London) Vol. 541; no. 7635; pp. 52 - 57
• Main Authors: Hite, Richard K., Tao, Xiao, MacKinnon, Roderick
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.01.2017; Nature Publishing Group
• Subjects: 631/45/269/1151; 631/535/1258/1259; 631/57/2270/1140; Humanities and Social Sciences; multidisciplinary; Observations; Physiological aspects; Potassium channels; Protein binding; Science

The precise control of an ion channel gate by environmental stimuli is crucial for the fulfilment of its biological role. The gate in Slo1 K + channels is regulated by two separate stimuli, intracellular Ca 2+ concentration and membrane voltage. Slo1 is thus central to understanding the relationship...