Oral immunization of a non-recombinant Lactococcus lactis surface displaying influenza hemagglutinin 1 (HA1) induces mucosal immunity in mice

• Published in: PloS one Vol. 12; no. 11; p. e0187718
• Main Authors: Jee, Pui-Fong, Tiong, Vunjia, Shu, Meng-Hooi, Khoo, Jing-Jing, Wong, Won Fen, Abdul Rahim, Raha, AbuBakar, Sazaly, Chang, Li-Yen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.11.2017; Public Library of Science (PLoS)
• Subjects: Administration, Oral; Animals; Antigens; Avian flu; Ayurvedic medicine; Biology and Life Sciences; Drug delivery systems; Education; Enzyme-Linked Immunosorbent Assay; Female; Gastrointestinal tract; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinins; House mouse; Humans; Immune response; Immune system; Immunity; Immunity, Mucosal; Immunization; Infections; Infectious diseases; Influenza; Influenza vaccines; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Lactobacillus; Lactococcus; Lactococcus lactis; Lactococcus lactis - metabolism; Lethal dose; Medicine and Health Sciences; Mice; Mice, Inbred BALB C; Mucosal immunity; Oral administration; Pandemics; Prevention; Proteins; Respiratory tract; Rodents; Small intestine; Vaccines; Virology; Viruses; Kuala Lumpur Malaysia; Malaysia

Mucosal immunization of influenza vaccine is potentially an effective approach for the prevention and control of influenza. The objective of the present study was to evaluate the ability of oral immunization with a non-recombinant Lactococcus lactis displaying HA1/L/AcmA recombinant protein, LL-HA1/...