Three-Staged Stereotactic Radiotherapy Without Whole Brain Irradiation for Large Metastatic Brain Tumors

• Published in: International journal of radiation oncology, biology, physics Vol. 74; no. 5; pp. 1543 - 1548
• Main Authors: Higuchi, Yoshinori, Serizawa, Toru, Nagano, Osamu, Matsuda, Shinji, Ono, Junichi, Sato, Makoto, Iwadate, Yasuo, Saeki, Naokatsu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2009
• Subjects: Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - secondary; Adenocarcinoma - surgery; Adult; Age; Aged; Aged, 80 and over; BRAIN; Brain metastasis; Brain Neoplasms - mortality; Brain Neoplasms - pathology; Brain Neoplasms - secondary; Brain Neoplasms - surgery; Breast Neoplasms - pathology; Carcinoma, Renal Cell - mortality; Carcinoma, Renal Cell - pathology; Carcinoma, Renal Cell - secondary; Carcinoma, Renal Cell - surgery; Colonic Neoplasms - pathology; Disease-Free Survival; Female; Hematology, Oncology and Palliative Medicine; Humans; Interfraction interval; IRRADIATION; Kidney Neoplasms - pathology; LARGE INTESTINE; Lung Neoplasms - pathology; LUNGS; Male; MAMMARY GLANDS; METASTASES; Middle Aged; NEOPLASMS; PATIENTS; RADIATION DOSES; Radiology; RADIOLOGY AND NUCLEAR MEDICINE; Radiosurgery - adverse effects; Radiosurgery - methods; Radiosurgery - mortality; RADIOTHERAPY; Remission Induction; Staged radiotherapy; Stereotactic radiosurgery; Stereotactic radiotherapy; SURGERY; Survival Rate; TOXICITY; Tumor Burden; Stereotactic radiosurgery; Staged radiotherapy; Interfraction interval; Brain metastasis; Stereotactic radiotherapy

To evaluate the efficacy and toxicity of staged stereotactic radiotherapy with a 2-week interfraction interval for unresectable brain metastases more than 10 cm 3 in volume. Subjects included 43 patients (24 men and 19 women), ranging in age from 41 to 84 years, who had large brain metastases (>...