ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress

• Published in: BioMed research international Vol. 2014; no. 2014; pp. 1 - 9
• Main Authors: Lu, Xiang-hong, Wan, Xiao-shan, Xiao, Ye-cheng, Lin, Yuan, Zhu, Hong, Ding, Ting, Yang, Ying, Huang, Yan, Zhang, Yi, Liu, Yan-Long, Xu, Zhu-mei, Xiao, Jian, Li, Xiao-kun
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014; Hindawi Publishing Corporation; John Wiley & Sons, Inc
• Subjects: 3T3 Cells; Activating Transcription Factor 4 - genetics; Amino acids; Animals; Binding sites; Cell Line; Diabetes; Disease; Endoplasmic reticulum; Endoplasmic Reticulum - genetics; Endoplasmic Reticulum Stress - genetics; Fibroblast growth factors; Fibroblast Growth Factors - genetics; Gene expression; Half-Life; Health aspects; Homeostasis; Hospitals; Insulin; Insulin resistance; Kinases; Male; Metabolic disorders; Mice; Mice, Inbred C57BL; Physiological aspects; Promoter Regions, Genetic - genetics; Protein Binding - genetics; Proteins; Rodents; Science; Signal Transduction - genetics; Stress (Physiology); Studies; Traditional Chinese medicine; Transcription Factor CHOP - genetics; Transcription, Genetic - genetics; Transcriptional Activation - genetics

Fibroblast growth factor 21 (FGF21) is an important endogenous regulator involved in the regulation of glucose and lipid metabolism. FGF21 expression is strongly induced in animal and human subjects with metabolic diseases, but little is known about the molecular mechanism. Endoplasmic reticulum (ER...