Multifunctional porous silicon nanoparticles for cancer theranostics

• Published in: Biomaterials Vol. 48; pp. 108 - 118
• Main Authors: Wang, Chang-Fang, Sarparanta, Mirkka P., Mäkilä, Ermei M., Hyvönen, Maija L.K., Laakkonen, Pirjo M., Salonen, Jarno J., Hirvonen, Jouni T., Airaksinen, Anu J., Santos, Hélder A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2015
• Subjects: Advanced Basic Science; Angiogenesis Inhibitors - administration & dosage; Animals; Biocompatibility; Biomedical materials; Cancer therapy; Cell Line, Tumor; cycloaddition reactions; Dentistry; Drugs; fluorescent antibody technique; fluorescent dyes; fluorescent labeling; Humans; hydrophobicity; image analysis; intravenous injection; Male; mice; Mice, Nude; monitoring; nanocarriers; Nanoparticles; Nanostructure; neoplasms; Neoplasms - diagnosis; Neoplasms - therapy; Niacinamide - administration & dosage; Niacinamide - analogs & derivatives; Phenylurea Compounds - administration & dosage; photons; Porous silicon; Porous silicon nanoparticles; precision medicine; radiolabeling; silicon; Silicon - therapeutic use; Sorafenib; Surface multifunctionalization; Surgical implants; Targeting drug delivery; Theranostic Nanomedicine; Theranostics; Tomography; Tumors; Surface multifunctionalization; Porous silicon nanoparticles; Targeting drug delivery; Theranostics; Cancer therapy

Nanomaterials provide a unique platform for the development of theranostic systems that combine diagnostic imaging modalities with a therapeutic payload in a single probe. In this work, dual-labeled iRGD-modified multifunctional porous silicon nanoparticles (PSi NPs) were prepared from dibenzocycloo...