Age-Related Loss of Brain Volume and T2 Relaxation Time in Youth With Type 1 Diabetes

• Published in: Diabetes care Vol. 35; no. 3; pp. 513 - 519
• Main Authors: Pell, Gaby S, Lin, Ashleigh, Wellard, R. Mark, Werther, George A, Cameron, Fergus J, Finch, Sue J, Papoutsis, Jennifer, Northam, Elisabeth A
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.03.2012
• Subjects: adolescence; Adolescent; Adult; adulthood; Age Factors; anatomy & histology; Biological and medical sciences; Brain; Brain - anatomy & histology; Brain - physiology; Children & youth; Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Humans; insulin-dependent diabetes mellitus; magnetic resonance imaging; Male; Measurement; Medical imaging; Medical research; Medical sciences; Metabolic diseases; Miscellaneous; Original Research; peers; physiology; physiopathology; prediction; Public health. Hygiene; Public health. Hygiene-occupational medicine; Regression Analysis; sex ratio; socioeconomic status; Type 1 diabetes; Young Adult; youth; Endocrinopathy; Human; Immunopathology; Brain; Nutrition; Central nervous system; Loss; Autoimmune disease; Metabolic diseases; Encephalon; Spin spin relaxation; Type 1 diabetes; Volume; Adolescent; Age; Endocrinology

OBJECTIVE2: Childhood-onset type 1 diabetes is associated with neurocognitive deficits, but there is limited evidence to date regarding associated neuroanatomical brain changes and their relationship to illness variables such as age at disease onset. This report examines age-related changes in volum...