Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

• Published in: Nature (London) Vol. 541; no. 7635; pp. 46 - 51
• Main Authors: Tao, Xiao, Hite, Richard K., MacKinnon, Roderick
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.01.2017; Nature Publishing Group
• Subjects: 631/45/269/1151; 631/535/1258/1259; 631/57/2270/1140; Calcium binding proteins; Humanities and Social Sciences; Methods; multidisciplinary; Physiological aspects; Potassium channels; Protein structure prediction; Science

The Ca 2+ -activated K + channel, Slo1, has an unusually large conductance and contains a voltage sensor and multiple chemical sensors. Dual activation by membrane voltage and Ca 2+ renders Slo1 central to processes that couple electrical signalling to Ca 2+ -mediated events such as muscle contracti...