Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b in Wild Birds and Live Bird Markets, Egypt

Clade 2.3.4.4 H5Nx influenza viruses have further diversified into several subclades. Sub-clade 2.3.4.4b H5N1 viruses have been widely circulating in wild birds and detected in Europe, Africa, Asia, and North America since October 2020. In this study, we report the first detection of highly pathogen...

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Published inPathogens (Basel) Vol. 12; no. 1; p. 36
Main Authors El-Shesheny, Rabeh, Moatasim, Yassmin, Mahmoud, Sara, Song, Yi, El Taweel, Ahmed, Gomaa, Mokhtar, Kamel, Mina, Sayes, Mohamed, Kandeil, Ahmed, Lam, Tommy, McKenzie, Pamela, Webby, Richard, Kayali, Ghazi, Ali, Mohamed
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.01.2023
MDPI
Subjects
Amino acids
Aquatic birds
Asia
Avian flu
Avian influenza
Avian influenza viruses
birds
Ducks
Egypt
Europe
Genes
Genomes
genomics
H5N1
Influenza
Influenza A
Influenza A virus
live bird markets
monitoring
Mutation
North America
Orthomyxoviridae
Pandemics
Pathogenicity
Pathogens
Phylogenetics
Phylogeny
Poultry
Viral proteins
Viruses
wild birds
zoonoses
Asia
North America
China
Egypt
Africa
Middle East
United Kingdom > UK
United States > US
Europe
Germany
wild birds
H5N1
poultry
Egypt
live bird markets
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Abstract Clade 2.3.4.4 H5Nx influenza viruses have further diversified into several subclades. Sub-clade 2.3.4.4b H5N1 viruses have been widely circulating in wild birds and detected in Europe, Africa, Asia, and North America since October 2020. In this study, we report the first detection of highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses in wild birds and domestic ducks from live bird markets in Egypt. Phylogenetic analysis revealed that the Egyptian H5N1 virus retained the genomic composition of Eurasian strains. Mutations in the viral proteins associated with zoonotic potential and pathogenicity were detected in Egyptian isolates. Egypt is considered a hot spot for the evolution of the influenza virus, so active surveillance of avian influenza viruses in Egypt is warranted.
AbstractList Clade 2.3.4.4 H5Nx influenza viruses have further diversified into several subclades. Sub-clade 2.3.4.4b H5N1 viruses have been widely circulating in wild birds and detected in Europe, Africa, Asia, and North America since October 2020. In this study, we report the first detection of highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses in wild birds and domestic ducks from live bird markets in Egypt. Phylogenetic analysis revealed that the Egyptian H5N1 virus retained the genomic composition of Eurasian strains. Mutations in the viral proteins associated with zoonotic potential and pathogenicity were detected in Egyptian isolates. Egypt is considered a hot spot for the evolution of the influenza virus, so active surveillance of avian influenza viruses in Egypt is warranted.
Clade 2.3.4.4 H5Nx influenza viruses have further diversified into several subclades. Sub-clade 2.3.4.4b H5N1 viruses have been widely circulating in wild birds and detected in Europe, Africa, Asia, and North America since October 2020. In this study, we report the first detection of highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses in wild birds and domestic ducks from live bird markets in Egypt. Phylogenetic analysis revealed that the Egyptian H5N1 virus retained the genomic composition of Eurasian strains. Mutations in the viral proteins associated with zoonotic potential and pathogenicity were detected in Egyptian isolates. Egypt is considered a hot spot for the evolution of the influenza virus, so active surveillance of avian influenza viruses in Egypt is warranted.Clade 2.3.4.4 H5Nx influenza viruses have further diversified into several subclades. Sub-clade 2.3.4.4b H5N1 viruses have been widely circulating in wild birds and detected in Europe, Africa, Asia, and North America since October 2020. In this study, we report the first detection of highly pathogenic avian influenza H5N1 clade 2.3.4.4b viruses in wild birds and domestic ducks from live bird markets in Egypt. Phylogenetic analysis revealed that the Egyptian H5N1 virus retained the genomic composition of Eurasian strains. Mutations in the viral proteins associated with zoonotic potential and pathogenicity were detected in Egyptian isolates. Egypt is considered a hot spot for the evolution of the influenza virus, so active surveillance of avian influenza viruses in Egypt is warranted.
Audience Academic
Author El-Shesheny, Rabeh
Moatasim, Yassmin
Kamel, Mina
Lam, Tommy
Ali, Mohamed
Song, Yi
Sayes, Mohamed
Kandeil, Ahmed
El Taweel, Ahmed
Gomaa, Mokhtar
McKenzie, Pamela
Webby, Richard
Mahmoud, Sara
Kayali, Ghazi
AuthorAffiliation 3 Laboratory of Data Discovery for Health Limited, Hong Kong SAR, China
6 Human Link, Dubai 3O-01-BA380, United Arab Emirates
2 State Key Laboratory of Emerging Infectious Diseases, School of Public Health, The University of Hong Kong, Hong Kong SAR, China
1 Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt
4 Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
5 Centre for Immunology & Infection Limited, Hong Kong SAR, China
AuthorAffiliation_xml – name: 3 Laboratory of Data Discovery for Health Limited, Hong Kong SAR, China
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Keywords wild birds
H5N1
poultry
Egypt
live bird markets
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– reference: 39339012 - Pathogens. 2024 Aug 27;13(9):726. doi: 10.3390/pathogens13090726.
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Snippet Clade 2.3.4.4 H5Nx influenza viruses have further diversified into several subclades. Sub-clade 2.3.4.4b H5N1 viruses have been widely circulating in wild...
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StartPage 36
SubjectTerms Amino acids
Aquatic birds
Asia
Avian flu
Avian influenza
Avian influenza viruses
birds
Ducks
Egypt
Europe
Genes
Genomes
genomics
H5N1
Influenza
Influenza A
Influenza A virus
live bird markets
monitoring
Mutation
North America
Orthomyxoviridae
Pandemics
Pathogenicity
Pathogens
Phylogenetics
Phylogeny
Poultry
Viral proteins
Viruses
wild birds
zoonoses
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Title Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b in Wild Birds and Live Bird Markets, Egypt
URI https://www.ncbi.nlm.nih.gov/pubmed/36678384
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Volume 12
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