Defective protein kinase A and C pathways are common causes of disordered zona pellucida (ZP)–induced acrosome reaction in normozoospermic infertile men with normal sperm-ZP binding

• Published in: Fertility and sterility Vol. 99; no. 1; pp. 86 - 91
• Main Authors: Liu, De-Yi, Liu, Ming-Li, Baker, H.W. Gordon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2013
• Subjects: acetates; acrosome reaction; Acrosome Reaction - drug effects; Acrosome Reaction - physiology; assisted reproductive technologies; Bucladesine - pharmacology; cAMP-dependent protein kinase; cyclic AMP; Cyclic AMP-Dependent Protein Kinases - physiology; Humans; In Vitro Techniques; Infertility, Male - physiopathology; Internal Medicine; Male; Male infertility; men; Obstetrics and Gynecology; patients; protein kinase C; Protein Kinase C - physiology; protein kinase pathways; Signal Transduction - physiology; Sperm-Ovum Interactions - drug effects; Sperm-Ovum Interactions - physiology; spermatozoa; Spermatozoa - drug effects; Spermatozoa - physiology; Tetradecanoylphorbol Acetate - pharmacology; zona pellucida; Zona Pellucida - physiology; zona pellucida–induced acrosome reaction; zona pellucida–induced acrosome reaction; Male infertility; protein kinase pathways

To determine association between defective protein kinases C (PKC) and A (PKA) and disordered zona pellucida (ZP)–induced acrosome reaction (DZPIAR) in normozoospermic infertile men with normal sperm-ZP binding. Sperm from DZPIAR infertile men were treated without (control) or with (test) phorbol my...