Parallel transport in diffeomorphisms distinguishes the time-dependent pattern of hippocampal surface deformation due to healthy aging and the dementia of the Alzheimer's type

• Published in: NeuroImage (Orlando, Fla.) Vol. 40; no. 1; pp. 68 - 76
• Main Authors: Qiu, Anqi, Younes, Laurent, Miller, Michael I., Csernansky, John G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2008; Elsevier Limited
• Subjects: Aged; Aging - pathology; Aging - physiology; Algorithms; Alzheimer Disease - pathology; Alzheimer's disease; Brain Mapping; Data Interpretation, Statistical; Deformation; Dementia; Euclidean space; Female; Hippocampus; Hippocampus - growth & development; Hippocampus - pathology; Humans; Hypothesis testing; Image Processing, Computer-Assisted; LDDMM; Longitudinal Studies; Magnetic Resonance Imaging; Male; Medical imaging; Methods; Normal Distribution; Parallel transport; Shape analysis; LDDMM; Shape analysis; Alzheimer's disease; Parallel transport; Hippocampus

Hippocampal surface structure was assessed at twice 2 years apart in 26 nondemented subjects (CDR 0), in 18 subjects with early dementia of Alzheimer type (DAT, CDR 0.5), and in 9 subjects who converted from the nondemented (CDR 0) to the demented (CDR 0.5) state using magnetic resonance (MR) imagin...