Proteomic analysis of canine oral tumor tissues using MALDI-TOF mass spectrometry and in-gel digestion coupled with mass spectrometry (GeLC MS/MS) approaches

• Published in: PloS one Vol. 13; no. 7; p. e0200619
• Main Authors: Pisamai, Sirinun, Roytrakul, Sittiruk, Phaonakrop, Narumon, Jaresitthikunchai, Janthima, Suriyaphol, Gunnaporn
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.07.2018; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Benign; Biology and life sciences; BRCA2 protein; Breast cancer; Chemotherapy; Chromatography; Cisplatin; Cisplatin - pharmacology; Deoxyribonucleic acid; Digestion; DNA; DNA repair; Dogs; Doxorubicin; Doxorubicin - pharmacology; Drugs; Female; Genetic engineering; Glutamate receptors; Glutamic acid receptors; Guanine; Guanine nucleotide exchange factor; Invasiveness; Ionization; Kinases; Liquid chromatography; Male; Mass spectrometry; Mass spectroscopy; Medicine and Health Sciences; Melanoma; Metastases; Molecular chains; Mouth Neoplasms - drug therapy; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; N-Methyl-D-aspartic acid receptors; Neoplasm Proteins - metabolism; Neoplasms; Notch1 protein; Oral cancer; Oral squamous cell carcinoma; Ovarian cancer; Physical Sciences; Proteasome activator; Protein binding; Protein-tyrosine-phosphatase; Proteins; Proteomes; Proteomics; Research and Analysis Methods; Sodium; Sodium channels (voltage-gated); Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy; Squamous cell carcinoma; Tonsil; Tumors; Tyrosine; Thailand; Bangkok Thailand

Oral tumors, including highly invasive and metastatic oral melanoma (OM), non-tonsillar oral squamous cell carcinoma (OSCC) and benign tumors (BN), are common neoplasms in dogs. Although these tumors behave differently, limited data of their protein expression profiles have been exhibited, particula...