The Character of the Muscarinic Receptors in Different Regions of the Rat Brain

• Published in: Proceedings of the Royal Society of London. Series B, Containing papers of a biological character Vol. 207; no. 1166; p. 1
• Main Authors: Birdsall, N J, Hulme, E C, Burgen, A
• Format: Journal Article
• Language: English
• Published: England The Royal Society 13.02.1980
• Subjects: Animals; Binding Sites; Brain - metabolism; Brain - physiology; Carbachol - metabolism; Mathematics; Oxotremorine - metabolism; Propylbenzilylcholine Mustard - metabolism; Rats; Receptors, Cholinergic - physiology; Receptors, Muscarinic - physiology

The binding characteristics of muscarinic receptors have been critically examined in six regions of the rat brain. The binding curves of antagonists are similar for all six areas but the binding curves of agonists show large differences. It is shown that in all regions there are three classes of rec...