The Character of the Muscarinic Receptors in Different Regions of the Rat Brain
The binding characteristics of muscarinic receptors have been critically examined in six regions of the rat brain. The binding curves of antagonists are similar for all six areas but the binding curves of agonists show large differences. It is shown that in all regions there are three classes of rec...
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| Published in | Proceedings of the Royal Society of London. Series B, Containing papers of a biological character Vol. 207; no. 1166; p. 1 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
The Royal Society
13.02.1980
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The binding characteristics of muscarinic receptors have been critically examined in six regions of the rat brain. The binding
curves of antagonists are similar for all six areas but the binding curves of agonists show large differences. It is shown
that in all regions there are three classes of receptors with similar binding characteristics but that these are present in
different proportions. The binding constants to the three receptor types of a range of agonists were examined and evidence
was produced in support of the theory that the subclasses of brain receptors are due to a single receptor subunit subject
to different conformational constraints. |
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| AbstractList | The binding characteristics of muscarinic receptors have been critically examined in six regions of the rat brain. The binding
curves of antagonists are similar for all six areas but the binding curves of agonists show large differences. It is shown
that in all regions there are three classes of receptors with similar binding characteristics but that these are present in
different proportions. The binding constants to the three receptor types of a range of agonists were examined and evidence
was produced in support of the theory that the subclasses of brain receptors are due to a single receptor subunit subject
to different conformational constraints. The binding characteristics of muscarinic receptors have been critically examined in six regions of the rat brain. The binding curves of antagonists are similar for all six areas but the binding curves of agonists show large differences. It is shown that in all regions there are three classes of receptors with similar binding characteristics but that these are present in different proportions. The binding constants to the three receptor types of a range of agonists were examined and evidence was produced in support of the theory that the subclasses of brain receptors are due to a single receptor subunit subject to different conformational constraints. |
| Author | N. J. M. Birdsall Arnold Burgen E. C. Hulme |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6102394$$D View this record in MEDLINE/PubMed |
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| Snippet | The binding characteristics of muscarinic receptors have been critically examined in six regions of the rat brain. The binding
curves of antagonists are... The binding characteristics of muscarinic receptors have been critically examined in six regions of the rat brain. The binding curves of antagonists are... |
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| SubjectTerms | Animals Binding Sites Brain - metabolism Brain - physiology Carbachol - metabolism Mathematics Oxotremorine - metabolism Propylbenzilylcholine Mustard - metabolism Rats Receptors, Cholinergic - physiology Receptors, Muscarinic - physiology |
| Title | The Character of the Muscarinic Receptors in Different Regions of the Rat Brain |
| URI | http://rspb.royalsocietypublishing.org/content/207/1166/1.abstract?cited-by=yes&legid=royprsb;207/1166/1 https://www.ncbi.nlm.nih.gov/pubmed/6102394 |
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