An imaging-guided platform for synergistic photodynamic/photothermal/chemo-therapy with pH/temperature-responsive drug release
To integrate biological imaging and multimodal therapies into one platform for enhanced anti-cancer efficacy, we have designed a novel core/shell structured nano-theranostic by conjugating photosensitive Au25(SR)18 – (SR refers to thiolate) clusters, pH/temperature-responsive polymer P(NIPAm-MAA), a...
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| Published in | Biomaterials Vol. 63; pp. 115 - 127 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.09.2015
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| Subjects | |
| Online Access | Get full text |
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| Abstract | To integrate biological imaging and multimodal therapies into one platform for enhanced anti-cancer efficacy, we have designed a novel core/shell structured nano-theranostic by conjugating photosensitive Au25(SR)18 – (SR refers to thiolate) clusters, pH/temperature-responsive polymer P(NIPAm-MAA), and anti-cancer drug (doxorubicin, DOX) onto the surface of mesoporous silica coated core–shell up-conversion nanoparticles (UCNPs). It is found that the photodynamic therapy (PDT) derived from the generated reactive oxygen species and the photothermal therapy (PTT) arising from the photothermal effect can be simultaneously triggered by a single 980 nm near infrared (NIR) light. Furthermore, the thermal effect can also stimulate the pH/temperature sensitive polymer in the cancer sites, thus realizing the targeted and controllable DOX release. The combined PDT, PTT and pH/temperature responsive chemo-therapy can markedly improve the therapeutic efficacy, which has been confirmed by both in intro and in vivo assays. Moreover, the doped rare earths endow the platform with dual-modal up-conversion luminescent (UCL) and computer tomography (CT) imaging properties, thus achieving the target of imaging-guided synergistic therapy under by a single NIR light. |
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| AbstractList | To integrate biological imaging and multimodal therapies into one platform for enhanced anti-cancer efficacy, we have designed a novel core/shell structured nano-theranostic by conjugating photosensitive Au25(SR)18 – (SR refers to thiolate) clusters, pH/temperature-responsive polymer P(NIPAm-MAA), and anti-cancer drug (doxorubicin, DOX) onto the surface of mesoporous silica coated core–shell up-conversion nanoparticles (UCNPs). It is found that the photodynamic therapy (PDT) derived from the generated reactive oxygen species and the photothermal therapy (PTT) arising from the photothermal effect can be simultaneously triggered by a single 980 nm near infrared (NIR) light. Furthermore, the thermal effect can also stimulate the pH/temperature sensitive polymer in the cancer sites, thus realizing the targeted and controllable DOX release. The combined PDT, PTT and pH/temperature responsive chemo-therapy can markedly improve the therapeutic efficacy, which has been confirmed by both in intro and in vivo assays. Moreover, the doped rare earths endow the platform with dual-modal up-conversion luminescent (UCL) and computer tomography (CT) imaging properties, thus achieving the target of imaging-guided synergistic therapy under by a single NIR light. To integrate biological imaging and multimodal therapies into one platform for enhanced anti-cancer efficacy, we have designed a novel core/shell structured nano-theranostic by conjugating photosensitive Au25(SR)18 – (SR refers to thiolate) clusters, pH/temperature-responsive polymer P(NIPAm-MAA), and anti-cancer drug (doxorubicin, DOX) onto the surface of mesoporous silica coated core–shell up-conversion nanoparticles (UCNPs). It is found that the photodynamic therapy (PDT) derived from the generated reactive oxygen species and the photothermal therapy (PTT) arising from the photothermal effect can be simultaneously triggered by a single 980 nm near infrared (NIR) light. Furthermore, the thermal effect can also stimulate the pH/temperature sensitive polymer in the cancer sites, thus realizing the targeted and controllable DOX release. The combined PDT, PTT and pH/temperature responsive chemo-therapy can markedly improve the therapeutic efficacy, which has been confirmed by both in intro and in vivo assays. Moreover, the doped rare earths endow the platform with dual-modal up-conversion luminescent (UCL) and computer tomography (CT) imaging properties, thus achieving the target of imaging-guided synergistic therapy under by a single NIR light. Abstract To integrate biological imaging and multimodal therapies into one platform for enhanced anti-cancer efficacy, we have designed a novel core/shell structured nano-theranostic by conjugating photosensitive Au 25SR 18 – (SR refers to thiolate) clusters, pH/temperature-responsive polymer P(NIPAm-MAA), and anti-cancer drug ( doxorubicin, DOX ) onto the surface of mesoporous silica coated core–shell up-conversion nanoparticles (UCNPs). It is found that the photodynamic therapy (PDT) derived from the generated reactive oxygen species and the photothermal therapy (PTT) arising from the photothermal effect can be simultaneously triggered by a single 980 nm near infrared (NIR) light. Furthermore, the thermal effect can also stimulate the pH/temperature sensitive polymer in the cancer sites, thus realizing the targeted and controllable DOX release. The combined PDT, PTT and pH/temperature responsive chemo-therapy can markedly improve the therapeutic efficacy, which has been confirmed by both in intro and in vivo assays. Moreover, the doped rare earths endow the platform with dual-modal up-conversion luminescent (UCL) and computer tomography (CT) imaging properties, thus achieving the target of imaging-guided synergistic therapy under by a single NIR light. |
| Author | Yang, Guixin Hou, Zhiyao Lin, Jun Yang, Piaoping Gai, Shili He, Fei Lv, Ruichan Dai, Yunlu |
| Author_xml | – sequence: 1 givenname: Ruichan surname: Lv fullname: Lv, Ruichan organization: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, PR China – sequence: 2 givenname: Piaoping surname: Yang fullname: Yang, Piaoping email: yangpiaoping@hrbeu.edu.cn organization: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, PR China – sequence: 3 givenname: Fei surname: He fullname: He, Fei organization: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, PR China – sequence: 4 givenname: Shili surname: Gai fullname: Gai, Shili organization: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, PR China – sequence: 5 givenname: Guixin surname: Yang fullname: Yang, Guixin organization: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, PR China – sequence: 6 givenname: Yunlu surname: Dai fullname: Dai, Yunlu organization: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, PR China – sequence: 7 givenname: Zhiyao surname: Hou fullname: Hou, Zhiyao organization: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China – sequence: 8 givenname: Jun surname: Lin fullname: Lin, Jun email: jlin@ciac.ac.cn organization: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26093792$$D View this record in MEDLINE/PubMed |
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| Snippet | To integrate biological imaging and multimodal therapies into one platform for enhanced anti-cancer efficacy, we have designed a novel core/shell structured... Abstract To integrate biological imaging and multimodal therapies into one platform for enhanced anti-cancer efficacy, we have designed a novel core/shell... |
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| SubjectTerms | Acrylamides - chemistry Acrylamides - therapeutic use Advanced Basic Science Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - therapeutic use Cell Line, Tumor computed tomography Delayed-Action Preparations - chemistry Delayed-Action Preparations - therapeutic use Dentistry doxorubicin Doxorubicin - administration & dosage Doxorubicin - therapeutic use Drug Liberation Effectiveness Female Humans Hydrogen-Ion Concentration Hyperthermia, Induced - methods image analysis Imaging luminescence Luminescent Agents - chemistry Luminescent Agents - therapeutic use Mice Mice, Inbred BALB C Nanoconjugates - chemistry Nanoconjugates - therapeutic use Nanoconjugates - ultrastructure nanoparticles neoplasms Neoplasms - diagnosis Neoplasms - therapy Optical Imaging pH/temperature-responsive Photochemotherapy - methods Photodynamic photosensitivity Photothermal Platforms polymers Polymethacrylic Acids - chemistry Polymethacrylic Acids - therapeutic use porous media Rare earth metals reactive oxygen species silica Surgical implants Temperature Theranostic Nanomedicine - methods therapeutics Therapy Tomography, X-Ray Computed Up-conversion Upconversion |
| Title | An imaging-guided platform for synergistic photodynamic/photothermal/chemo-therapy with pH/temperature-responsive drug release |
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