Evaluation of cell count and classification capabilities in body fluids using a fully automated Sysmex XN equipped with high-sensitive Analysis (hsA) mode and DI-60 hematology analyzer system

• Published in: PloS one Vol. 13; no. 4; p. e0195923
• Main Authors: Takemura, Hiroyuki, Ai, Tomohiko, Kimura, Konobu, Nagasaka, Kaori, Takahashi, Toshihiro, Tsuchiya, Koji, Yang, Haeun, Konishi, Aya, Uchihashi, Kinya, Horii, Takashi, Tabe, Yoko, Ohsaka, Akimichi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.04.2018; Public Library of Science (PLoS)
• Subjects: Algorithms; Analytical instruments; Automation; Biology and Life Sciences; Blood; Blood cell count; Body fluids; Cell morphology; Cell number; Cerebrospinal fluid; Classification; Coefficient of variation; Counting; Cytology; Cytometry; Diagnostic systems; Digital imaging; Flow cytometry; Fluids; Hematology; Hospitals; Laboratories; Leukocytes; Linearity; Medicine; Medicine and Health Sciences; Methods; Monocytes; Morphology; Product development; Reproducibility; Research and Analysis Methods; Stem cells; Technology assessment; University graduates; Japan

The XN series automated hematology analyzer has been equipped with a body fluid (BF) mode to count and differentiate leukocytes in BF samples including cerebrospinal fluid (CSF). However, its diagnostic accuracy is not reliable for CSF samples with low cell concentration at the border between normal...