Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology
In humans and dogs, a temporal decline in semen quality and increased incidence of testicular cancer is hypothesised to be associated with exposure to anthropogenic chemicals, particularly during fetal development. Human studies suggest that differential exposures to environmental chemicals may be a...
Saved in:
Published in | Scientific reports Vol. 11; no. 1; pp. 7361 - 11 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.04.2021
Nature Publishing Group Nature Portfolio |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | In humans and dogs, a temporal decline in semen quality and increased incidence of testicular cancer is hypothesised to be associated with exposure to anthropogenic chemicals, particularly during fetal development. Human studies suggest that differential exposures to environmental chemicals may be associated with geographical differences in male reproductive health. Here we investigate testicular chemical profiles and pathologies in dogs residing in the UK [West Midlands (WM), East Midlands (EM), South East (SE)], Denmark (Copenhagen) and Finland (Vantaa). Testes, surplus from routine castrations, contained region specific differences in relative concentrations of diethylhexyl phthalate (DEHP), polybrominated diphenyl ethers (PBDE) and polychlorinated biphenyls (PCB). Relative to UK regions, testes from dogs living in Finland and Denmark had higher concentrations of PBDE and lower concentrations of DEHP and PCBs. Regional differences in the UK in PCB concentrations were also observed. Dog testes from Finland had fewer pathologies, reduced testicular area stained for Sertoli and germ cells and evidence of reduced cellular proliferation. Since the geographical differences in testis pathologies in dogs parallel reports of regional differences in human testicular cancer, we postulate that this may reflect chemical effects within the testis and that this may be related to environmental influences on male reproductive function. |
---|---|
AbstractList | In humans and dogs, a temporal decline in semen quality and increased incidence of testicular cancer is hypothesised to be associated with exposure to anthropogenic chemicals, particularly during fetal development. Human studies suggest that differential exposures to environmental chemicals may be associated with geographical differences in male reproductive health. Here we investigate testicular chemical profiles and pathologies in dogs residing in the UK [West Midlands (WM), East Midlands (EM), South East (SE)], Denmark (Copenhagen) and Finland (Vantaa). Testes, surplus from routine castrations, contained region specific differences in relative concentrations of diethylhexyl phthalate (DEHP), polybrominated diphenyl ethers (PBDE) and polychlorinated biphenyls (PCB). Relative to UK regions, testes from dogs living in Finland and Denmark had higher concentrations of PBDE and lower concentrations of DEHP and PCBs. Regional differences in the UK in PCB concentrations were also observed. Dog testes from Finland had fewer pathologies, reduced testicular area stained for Sertoli and germ cells and evidence of reduced cellular proliferation. Since the geographical differences in testis pathologies in dogs parallel reports of regional differences in human testicular cancer, we postulate that this may reflect chemical effects within the testis and that this may be related to environmental influences on male reproductive function. Abstract In humans and dogs, a temporal decline in semen quality and increased incidence of testicular cancer is hypothesised to be associated with exposure to anthropogenic chemicals, particularly during fetal development. Human studies suggest that differential exposures to environmental chemicals may be associated with geographical differences in male reproductive health. Here we investigate testicular chemical profiles and pathologies in dogs residing in the UK [West Midlands (WM), East Midlands (EM), South East (SE)], Denmark (Copenhagen) and Finland (Vantaa). Testes, surplus from routine castrations, contained region specific differences in relative concentrations of diethylhexyl phthalate (DEHP), polybrominated diphenyl ethers (PBDE) and polychlorinated biphenyls (PCB). Relative to UK regions, testes from dogs living in Finland and Denmark had higher concentrations of PBDE and lower concentrations of DEHP and PCBs. Regional differences in the UK in PCB concentrations were also observed. Dog testes from Finland had fewer pathologies, reduced testicular area stained for Sertoli and germ cells and evidence of reduced cellular proliferation. Since the geographical differences in testis pathologies in dogs parallel reports of regional differences in human testicular cancer, we postulate that this may reflect chemical effects within the testis and that this may be related to environmental influences on male reproductive function. |
ArticleNumber | 7361 |
Author | Sumner, Rebecca N. Agerholm, Jorgen S. Lindh, Lena England, Gary C. W. Lea, Richard G. Byers, Andrew Zhang, Zulin |
Author_xml | – sequence: 1 givenname: Rebecca N. surname: Sumner fullname: Sumner, Rebecca N. organization: School of Veterinary Medicine and Science, The University of Nottingham – sequence: 2 givenname: Andrew surname: Byers fullname: Byers, Andrew organization: School of Veterinary Medicine and Science, The University of Nottingham – sequence: 3 givenname: Zulin surname: Zhang fullname: Zhang, Zulin organization: Environmental and Biochemical Sciences, The James Hutton Institute – sequence: 4 givenname: Jorgen S. surname: Agerholm fullname: Agerholm, Jorgen S. organization: Department of Clinical Veterinary Sciences, University of Copenhagen – sequence: 5 givenname: Lena surname: Lindh fullname: Lindh, Lena organization: Department of Production Animal Medicine, University of Helsinki – sequence: 6 givenname: Gary C. W. surname: England fullname: England, Gary C. W. organization: School of Veterinary Medicine and Science, The University of Nottingham – sequence: 7 givenname: Richard G. surname: Lea fullname: Lea, Richard G. email: richard.lea@nottingham.ac.uk organization: School of Veterinary Medicine and Science, The University of Nottingham |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33795811$$D View this record in MEDLINE/PubMed |
BookMark | eNp9UUtvFSEYJabGPuwfcGFIXE_lMczAxsQ0VZs0caNrwsA3j5sZuAK3Zv693E6t7UZCwgec7xw45xyd-OABoXeUXFHC5cdUU6FkRRitZCOJqNZX6IyRWlSMM3byrD5FlyntSBmCqZqqN-iU81YJSekZyjf-forBL-CzmbEdYZmsmROePHZhwBlSmThCP4PNOI8wRTxAGKLZj0ckTuEQLWDjHV7MirtSphTsZDI4_HvKIzZzhlg2e5PHMIdhfYte90UDLh_XC_Tzy82P62_V3fevt9ef7yorFM8VbbumccQ1YACgE0JQRizjvG8skW1NLFGsqZWkwJztm9a1PYWeKdKDcJ3iF-h243XB7PQ-TouJqw5m0g8HIQ7axDzZGTRvGTGNsDUFUTPadLVVLaheUal6Z2Xh-rRx7Q_dAs4Wv6KZX5C-vPHTqIdwryWhjVS8EHx4JIjh16HYqnfFOV_-r5kgbYlQ8qMM21A2hpSK7U8KlOhj8HoLXpfg9UPwei1N75-_7anlb8wFwDdAKld-gPhP-z-0fwA7Qr3T |
CitedBy_id | crossref_primary_10_3390_ani13182923 crossref_primary_10_5985_emcr_20230009 crossref_primary_10_1016_j_tiv_2022_105452 crossref_primary_10_3390_ani13030378 crossref_primary_10_1093_biolre_ioae075 crossref_primary_10_1016_j_envint_2022_107322 crossref_primary_10_3390_ijms232214229 crossref_primary_10_1289_EHP12949 |
Cites_doi | 10.1016/s0140-6736(72)91909-5 10.1210/en.2019-00486 10.1016/j.ejca.2013.11.035 10.1289/EHP1953 10.1016/j.ijheh.2008.04.005 10.1097/MD.0000000000012390 10.1152/physrev.00017.2015 10.1016/j.lfs.2017.11.039 10.1016/j.theriogenology.2008.02.009 10.1016/j.envres.2018.07.004 10.1016/j.reprotox.2011.02.005 10.1093/humrep/del279 10.1111/bju.14148 10.1093/humupd/dmx022 10.1002/ijc.32810 10.1016/j.jcpa.2007.11.002 10.1111/j.1365-2605.2011.01171.x 10.1111/j.1365-2605.2011.01234.x 10.1016/j.envint.2018.11.037 10.1038/srep31281 10.1093/humrep/16.5.972 10.1136/oemed-2015-102860 10.1002/ijc.2910590108 10.1186/1477-5751-12-2 10.1289/ehp.00108961 10.1016/S0140-6736(15)00991-5 10.1016/j.aju.2017.11.018 10.1093/jat/34.7.400 10.1136/bmj.305.6854.609 10.1530/REP-20-0042 10.1111/andr.12550 10.1289/ehp.8028 10.1016/j.taap.2005.01.058 10.1038/s41598-019-39913-9 10.1158/1055-9965.2157.13.12 |
ContentType | Journal Article |
Copyright | The Author(s) 2021 The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: The Author(s) 2021 – notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | C6C NPM AAYXX CITATION 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PIMPY PQEST PQQKQ PQUKI Q9U 5PM DOA |
DOI | 10.1038/s41598-021-86805-y |
DatabaseName | Springer Nature OA Free Journals PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Science Database Biological Science Database Publicly Available Content (ProQuest) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic PubMed Central (Full Participant titles) Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) |
DatabaseTitleList | PubMed Publicly Available Content Database CrossRef |
Database_xml | – sequence: 1 dbid: C6C name: SpringerOpen(OpenAccess) url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: Open Access: DOAJ - Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2045-2322 |
EndPage | 11 |
ExternalDocumentID | oai_doaj_org_article_3720a65c41e54216b4c97e9f9189fdc8 10_1038_s41598_021_86805_y 33795811 |
Genre | Journal Article |
GeographicLocations | United Kingdom--UK Denmark Finland |
GeographicLocations_xml | – name: Finland – name: United Kingdom--UK – name: Denmark |
GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ADBBV ADRAZ AENEX AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RIG RNT RNTTT RPM SNYQT UKHRP NPM AAYXX CITATION 7XB 8FK K9. PQEST PQUKI Q9U 5PM AFPKN |
ID | FETCH-LOGICAL-c593t-17b66d0d6eaeeeb555120c233f6c08740c09264981e2dcf67d7f1ef290fe5db93 |
IEDL.DBID | RPM |
ISSN | 2045-2322 |
IngestDate | Tue Oct 22 15:01:41 EDT 2024 Tue Sep 17 21:12:45 EDT 2024 Sat Nov 09 14:08:32 EST 2024 Fri Dec 06 01:48:06 EST 2024 Wed Oct 16 00:43:52 EDT 2024 Fri Oct 11 20:36:30 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c593t-17b66d0d6eaeeeb555120c233f6c08740c09264981e2dcf67d7f1ef290fe5db93 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016893/ |
PMID | 33795811 |
PQID | 2507805838 |
PQPubID | 2041939 |
PageCount | 11 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_3720a65c41e54216b4c97e9f9189fdc8 pubmedcentral_primary_oai_pubmedcentral_nih_gov_8016893 proquest_journals_2507805838 crossref_primary_10_1038_s41598_021_86805_y pubmed_primary_33795811 springer_journals_10_1038_s41598_021_86805_y |
PublicationCentury | 2000 |
PublicationDate | 2021-04-01 |
PublicationDateYYYYMMDD | 2021-04-01 |
PublicationDate_xml | – month: 04 year: 2021 text: 2021-04-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | London |
PublicationPlace_xml | – name: London – name: England |
PublicationTitle | Scientific reports |
PublicationTitleAbbrev | Sci Rep |
PublicationTitleAlternate | Sci Rep |
PublicationYear | 2021 |
Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
References | Skakkebaek, Rajpert-De Meyts, Main (CR4) 2001; 16 Paul (CR9) 2005; 113 Sumner, Tomlinson, Craigon, England, Lea (CR18) 2019; 9 Le Cornet (CR27) 2015; 72 Levine (CR3) 2017; 23 Xing, Bai (CR6) 2018; 194 Rajpert-De Meyts, McGlynn, Okamoto, Jewett, Bokemeyer (CR12) 2016; 387 Chung, Buck Louis, Kannan, Patel (CR30) 2019; 125 Swan, Elkin, Fenster (CR2) 2000; 108 Bellingham (CR10) 2012; 35 Frederiksen, Vorkamp, Thomsen, Knudsen (CR33) 2009; 212 Park, Kim, Elghiaty, Ham (CR11) 2018; 97 Cook, Trabert, McGlynn (CR13) 2011; 34 Skakkebaek (CR14) 1972; 2 Smarr (CR8) 2018; 167 Frederiksen, Jorgensen, Andersson (CR7) 2010; 34 Grieco, Riccardi, Veronesi, Giudice, Finazzi (CR24) 2008; 70 Ylonen, Jyrkkio, Pukkala, Syvanen, Bostrom (CR25) 2018; 122 Lehmann (CR31) 2018; 126 Znaor (CR28) 2020; 147 Elbardisi (CR5) 2018; 16 Virtanen, Rajpert-De Meyts, Main, Skakkebaek, Toppari (CR21) 2005; 207 Richiardi (CR22) 2004; 13 Rodprasert (CR29) 2019; 7 Sumner (CR17) 2020; 159 Andrade (CR35) 2013; 12 Skakkebaek (CR19) 2016; 96 Lea (CR16) 2016; 6 Grieco (CR23) 2008; 138 Abdelouahab, Ainmelk, Takser (CR32) 2011; 31 Le Cornet (CR26) 2014; 50 Carlsen, Giwercman, Keiding, Skakkebaek (CR1) 1992; 305 Adami (CR20) 1994; 59 Fenichel, Chevalier (CR15) 2019; 160 McLachlan, Rajpert-De Meyts, Hoei-Hansen, de Kretser, Skakkebaek (CR34) 2007; 22 O Ylonen (86805_CR25) 2018; 122 MK Chung (86805_CR30) 2019; 125 LP Andrade (86805_CR35) 2013; 12 HO Adami (86805_CR20) 1994; 59 GM Lehmann (86805_CR31) 2018; 126 E Carlsen (86805_CR1) 1992; 305 NE Skakkebaek (86805_CR19) 2016; 96 MB Cook (86805_CR13) 2011; 34 W Rodprasert (86805_CR29) 2019; 7 C Le Cornet (86805_CR26) 2014; 50 E Rajpert-De Meyts (86805_CR12) 2016; 387 RN Sumner (86805_CR18) 2019; 9 H Frederiksen (86805_CR7) 2010; 34 NE Skakkebaek (86805_CR14) 1972; 2 NE Skakkebaek (86805_CR4) 2001; 16 JS Xing (86805_CR6) 2018; 194 L Richiardi (86805_CR22) 2004; 13 V Grieco (86805_CR23) 2008; 138 P Fenichel (86805_CR15) 2019; 160 M Bellingham (86805_CR10) 2012; 35 HE Virtanen (86805_CR21) 2005; 207 H Levine (86805_CR3) 2017; 23 C Le Cornet (86805_CR27) 2015; 72 A Znaor (86805_CR28) 2020; 147 RG Lea (86805_CR16) 2016; 6 RI McLachlan (86805_CR34) 2007; 22 SH Swan (86805_CR2) 2000; 108 H Elbardisi (86805_CR5) 2018; 16 M Frederiksen (86805_CR33) 2009; 212 MM Smarr (86805_CR8) 2018; 167 JS Park (86805_CR11) 2018; 97 C Paul (86805_CR9) 2005; 113 V Grieco (86805_CR24) 2008; 70 RN Sumner (86805_CR17) 2020; 159 N Abdelouahab (86805_CR32) 2011; 31 |
References_xml | – volume: 2 start-page: 516 year: 1972 end-page: 517 ident: CR14 article-title: Possible carcinoma-in-situ of the testis publication-title: Lancet doi: 10.1016/s0140-6736(72)91909-5 contributor: fullname: Skakkebaek – volume: 160 start-page: 2981 year: 2019 end-page: 2989 ident: CR15 article-title: Is testicular germ cell cancer estrogen dependent? The role of endocrine disrupting chemicals publication-title: Endocrinology doi: 10.1210/en.2019-00486 contributor: fullname: Chevalier – volume: 50 start-page: 831 year: 2014 end-page: 839 ident: CR26 article-title: Testicular cancer incidence to rise by 25% by 2025 in Europe? Model-based predictions in 40 countries using population-based registry data publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2013.11.035 contributor: fullname: Le Cornet – volume: 126 start-page: 96001 year: 2018 ident: CR31 article-title: Environmental chemicals in breast milk and formula: Exposure and risk assessment implications publication-title: Environ. Health Perspect. doi: 10.1289/EHP1953 contributor: fullname: Lehmann – volume: 212 start-page: 109 year: 2009 end-page: 134 ident: CR33 article-title: Human internal and external exposure to PBDEs—A review of levels and sources publication-title: Int. J. Hyg. Environ. Health doi: 10.1016/j.ijheh.2008.04.005 contributor: fullname: Knudsen – volume: 97 start-page: e12390 year: 2018 ident: CR11 article-title: Recent global trends in testicular cancer incidence and mortality publication-title: Medicine doi: 10.1097/MD.0000000000012390 contributor: fullname: Ham – volume: 96 start-page: 55 year: 2016 end-page: 97 ident: CR19 article-title: Male reproductive disorders and fertility trends: Influences of environment and genetic susceptibility publication-title: Physiol. Rev. doi: 10.1152/physrev.00017.2015 contributor: fullname: Skakkebaek – volume: 194 start-page: 120 year: 2018 end-page: 129 ident: CR6 article-title: Is testicular dysgenesis syndrome a genetic, endocrine, or environmental disease, or an unexplained reproductive disorder? publication-title: Life Sci. doi: 10.1016/j.lfs.2017.11.039 contributor: fullname: Bai – volume: 70 start-page: 53 year: 2008 end-page: 60 ident: CR24 article-title: Evidence of testicular dysgenesis syndrome in the dog publication-title: Theriogenology doi: 10.1016/j.theriogenology.2008.02.009 contributor: fullname: Finazzi – volume: 167 start-page: 78 year: 2018 end-page: 86 ident: CR8 article-title: Preconception seminal plasma concentrations of endocrine disrupting chemicals in relation to semen quality parameters among male partners planning for pregnancy publication-title: Environ. Res. doi: 10.1016/j.envres.2018.07.004 contributor: fullname: Smarr – volume: 31 start-page: 546 year: 2011 end-page: 550 ident: CR32 article-title: Polybrominated diphenyl ethers and sperm quality publication-title: Reprod. Toxicol. doi: 10.1016/j.reprotox.2011.02.005 contributor: fullname: Takser – volume: 22 start-page: 2 year: 2007 end-page: 16 ident: CR34 article-title: Histological evaluation of the human testis—Approaches to optimizing the clinical value of the assessment: Mini review publication-title: Hum. Reprod. doi: 10.1093/humrep/del279 contributor: fullname: Skakkebaek – volume: 122 start-page: 384 year: 2018 end-page: 393 ident: CR25 article-title: Time trends and occupational variation in the incidence of testicular cancer in the Nordic countries publication-title: BJU Int. doi: 10.1111/bju.14148 contributor: fullname: Bostrom – volume: 23 start-page: 646 year: 2017 end-page: 659 ident: CR3 article-title: Temporal trends in sperm count: A systematic review and meta-regression analysis publication-title: Hum. Reprod. Update doi: 10.1093/humupd/dmx022 contributor: fullname: Levine – volume: 147 start-page: 820 year: 2020 end-page: 828 ident: CR28 article-title: Testicular cancer incidence predictions in Europe 2010–2035: A rising burden despite population ageing publication-title: Int. J. Cancer doi: 10.1002/ijc.32810 contributor: fullname: Znaor – volume: 138 start-page: 86 year: 2008 end-page: 89 ident: CR23 article-title: Canine testicular tumours: A study on 232 dogs publication-title: J. Comp. Pathol. doi: 10.1016/j.jcpa.2007.11.002 contributor: fullname: Grieco – volume: 34 start-page: e68 year: 2011 end-page: 84 ident: CR13 article-title: Organochlorine compounds and testicular dysgenesis syndrome: Human data publication-title: Int. J. Androl. doi: 10.1111/j.1365-2605.2011.01171.x contributor: fullname: McGlynn – volume: 35 start-page: 317 year: 2012 end-page: 329 ident: CR10 article-title: Foetal and post-natal exposure of sheep to sewage sludge chemicals disrupts sperm production in adulthood in a subset of animals publication-title: Int. J. Androl. doi: 10.1111/j.1365-2605.2011.01234.x contributor: fullname: Bellingham – volume: 125 start-page: 505 year: 2019 end-page: 514 ident: CR30 article-title: Exposome-wide association study of semen quality: Systematic discovery of endocrine disrupting chemical biomarkers in fertility require large sample sizes publication-title: Environ. Int. doi: 10.1016/j.envint.2018.11.037 contributor: fullname: Patel – volume: 13 start-page: 2157 year: 2004 end-page: 2166 ident: CR22 article-title: Testicular cancer incidence in eight northern European countries: Secular and recent trends publication-title: Cancer Epidemiol. Biomark. Prev. contributor: fullname: Richiardi – volume: 6 start-page: 31281 year: 2016 ident: CR16 article-title: Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism publication-title: Sci. Rep. doi: 10.1038/srep31281 contributor: fullname: Lea – volume: 16 start-page: 972 year: 2001 end-page: 978 ident: CR4 article-title: Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects publication-title: Hum. Reprod. doi: 10.1093/humrep/16.5.972 contributor: fullname: Main – volume: 72 start-page: 805 year: 2015 end-page: 811 ident: CR27 article-title: Testicular germ cell tumours and parental occupational exposure to pesticides: A register-based case-control study in the Nordic countries (NORD-TEST study) publication-title: Occup. Environ. Med. doi: 10.1136/oemed-2015-102860 contributor: fullname: Le Cornet – volume: 59 start-page: 33 year: 1994 end-page: 38 ident: CR20 article-title: Testicular cancer in nine northern European countries publication-title: Int. J. Cancer doi: 10.1002/ijc.2910590108 contributor: fullname: Adami – volume: 12 start-page: 2 year: 2013 ident: CR35 article-title: Maternal undernutrition does not alter Sertoli cell numbers or the expression of key developmental markers in the mid-gestation ovine fetal testis publication-title: J. Negat. Results Biomed. doi: 10.1186/1477-5751-12-2 contributor: fullname: Andrade – volume: 108 start-page: 961 year: 2000 end-page: 966 ident: CR2 article-title: The question of declining sperm density revisited: An analysis of 101 studies published 1934–1996 publication-title: Environ. Health Perspect. doi: 10.1289/ehp.00108961 contributor: fullname: Fenster – volume: 387 start-page: 1762 year: 2016 end-page: 1774 ident: CR12 article-title: Testicular germ cell tumours publication-title: Lancet doi: 10.1016/S0140-6736(15)00991-5 contributor: fullname: Bokemeyer – volume: 16 start-page: 3 year: 2018 end-page: 9 ident: CR5 article-title: Geographical differences in semen characteristics of 13 892 infertile men publication-title: Arab. J. Urol. doi: 10.1016/j.aju.2017.11.018 contributor: fullname: Elbardisi – volume: 34 start-page: 400 year: 2010 end-page: 410 ident: CR7 article-title: Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry publication-title: J. Anal. Toxicol. doi: 10.1093/jat/34.7.400 contributor: fullname: Andersson – volume: 305 start-page: 609 year: 1992 end-page: 613 ident: CR1 article-title: Evidence for decreasing quality of semen during past 50 years publication-title: BMJ doi: 10.1136/bmj.305.6854.609 contributor: fullname: Skakkebaek – volume: 159 start-page: R265 year: 2020 end-page: R276 ident: CR17 article-title: The dog as a sentinel species for environmental effects on human fertility publication-title: Reproduction doi: 10.1530/REP-20-0042 contributor: fullname: Sumner – volume: 7 start-page: 15 year: 2019 end-page: 23 ident: CR29 article-title: An update on semen quality among young Finnish men and comparison with Danish data publication-title: Andrology doi: 10.1111/andr.12550 contributor: fullname: Rodprasert – volume: 113 start-page: 1580 year: 2005 end-page: 1587 ident: CR9 article-title: Cellular and hormonal disruption of fetal testis development in sheep reared on pasture treated with sewage sludge publication-title: Environ. Health Perspect. doi: 10.1289/ehp.8028 contributor: fullname: Paul – volume: 207 start-page: 501 year: 2005 end-page: 505 ident: CR21 article-title: Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2005.01.058 contributor: fullname: Toppari – volume: 9 start-page: 3409 year: 2019 ident: CR18 article-title: Independent and combined effects of diethylhexyl phthalate and polychlorinated biphenyl 153 on sperm quality in the human and dog publication-title: Sci. Rep. doi: 10.1038/s41598-019-39913-9 contributor: fullname: Lea – volume: 147 start-page: 820 year: 2020 ident: 86805_CR28 publication-title: Int. J. Cancer doi: 10.1002/ijc.32810 contributor: fullname: A Znaor – volume: 305 start-page: 609 year: 1992 ident: 86805_CR1 publication-title: BMJ doi: 10.1136/bmj.305.6854.609 contributor: fullname: E Carlsen – volume: 7 start-page: 15 year: 2019 ident: 86805_CR29 publication-title: Andrology doi: 10.1111/andr.12550 contributor: fullname: W Rodprasert – volume: 31 start-page: 546 year: 2011 ident: 86805_CR32 publication-title: Reprod. Toxicol. doi: 10.1016/j.reprotox.2011.02.005 contributor: fullname: N Abdelouahab – volume: 12 start-page: 2 year: 2013 ident: 86805_CR35 publication-title: J. Negat. Results Biomed. doi: 10.1186/1477-5751-12-2 contributor: fullname: LP Andrade – volume: 108 start-page: 961 year: 2000 ident: 86805_CR2 publication-title: Environ. Health Perspect. doi: 10.1289/ehp.00108961 contributor: fullname: SH Swan – volume: 138 start-page: 86 year: 2008 ident: 86805_CR23 publication-title: J. Comp. Pathol. doi: 10.1016/j.jcpa.2007.11.002 contributor: fullname: V Grieco – volume: 59 start-page: 33 year: 1994 ident: 86805_CR20 publication-title: Int. J. Cancer doi: 10.1002/ijc.2910590108 contributor: fullname: HO Adami – volume: 207 start-page: 501 year: 2005 ident: 86805_CR21 publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2005.01.058 contributor: fullname: HE Virtanen – volume: 2 start-page: 516 year: 1972 ident: 86805_CR14 publication-title: Lancet doi: 10.1016/s0140-6736(72)91909-5 contributor: fullname: NE Skakkebaek – volume: 23 start-page: 646 year: 2017 ident: 86805_CR3 publication-title: Hum. Reprod. Update doi: 10.1093/humupd/dmx022 contributor: fullname: H Levine – volume: 16 start-page: 972 year: 2001 ident: 86805_CR4 publication-title: Hum. Reprod. doi: 10.1093/humrep/16.5.972 contributor: fullname: NE Skakkebaek – volume: 16 start-page: 3 year: 2018 ident: 86805_CR5 publication-title: Arab. J. Urol. doi: 10.1016/j.aju.2017.11.018 contributor: fullname: H Elbardisi – volume: 387 start-page: 1762 year: 2016 ident: 86805_CR12 publication-title: Lancet doi: 10.1016/S0140-6736(15)00991-5 contributor: fullname: E Rajpert-De Meyts – volume: 6 start-page: 31281 year: 2016 ident: 86805_CR16 publication-title: Sci. Rep. doi: 10.1038/srep31281 contributor: fullname: RG Lea – volume: 35 start-page: 317 year: 2012 ident: 86805_CR10 publication-title: Int. J. Androl. doi: 10.1111/j.1365-2605.2011.01234.x contributor: fullname: M Bellingham – volume: 212 start-page: 109 year: 2009 ident: 86805_CR33 publication-title: Int. J. Hyg. Environ. Health doi: 10.1016/j.ijheh.2008.04.005 contributor: fullname: M Frederiksen – volume: 13 start-page: 2157 year: 2004 ident: 86805_CR22 publication-title: Cancer Epidemiol. Biomark. Prev. doi: 10.1158/1055-9965.2157.13.12 contributor: fullname: L Richiardi – volume: 22 start-page: 2 year: 2007 ident: 86805_CR34 publication-title: Hum. Reprod. doi: 10.1093/humrep/del279 contributor: fullname: RI McLachlan – volume: 122 start-page: 384 year: 2018 ident: 86805_CR25 publication-title: BJU Int. doi: 10.1111/bju.14148 contributor: fullname: O Ylonen – volume: 34 start-page: 400 year: 2010 ident: 86805_CR7 publication-title: J. Anal. Toxicol. doi: 10.1093/jat/34.7.400 contributor: fullname: H Frederiksen – volume: 194 start-page: 120 year: 2018 ident: 86805_CR6 publication-title: Life Sci. doi: 10.1016/j.lfs.2017.11.039 contributor: fullname: JS Xing – volume: 72 start-page: 805 year: 2015 ident: 86805_CR27 publication-title: Occup. Environ. Med. doi: 10.1136/oemed-2015-102860 contributor: fullname: C Le Cornet – volume: 34 start-page: e68 year: 2011 ident: 86805_CR13 publication-title: Int. J. Androl. doi: 10.1111/j.1365-2605.2011.01171.x contributor: fullname: MB Cook – volume: 96 start-page: 55 year: 2016 ident: 86805_CR19 publication-title: Physiol. Rev. doi: 10.1152/physrev.00017.2015 contributor: fullname: NE Skakkebaek – volume: 159 start-page: R265 year: 2020 ident: 86805_CR17 publication-title: Reproduction doi: 10.1530/REP-20-0042 contributor: fullname: RN Sumner – volume: 160 start-page: 2981 year: 2019 ident: 86805_CR15 publication-title: Endocrinology doi: 10.1210/en.2019-00486 contributor: fullname: P Fenichel – volume: 126 start-page: 96001 year: 2018 ident: 86805_CR31 publication-title: Environ. Health Perspect. doi: 10.1289/EHP1953 contributor: fullname: GM Lehmann – volume: 113 start-page: 1580 year: 2005 ident: 86805_CR9 publication-title: Environ. Health Perspect. doi: 10.1289/ehp.8028 contributor: fullname: C Paul – volume: 70 start-page: 53 year: 2008 ident: 86805_CR24 publication-title: Theriogenology doi: 10.1016/j.theriogenology.2008.02.009 contributor: fullname: V Grieco – volume: 97 start-page: e12390 year: 2018 ident: 86805_CR11 publication-title: Medicine doi: 10.1097/MD.0000000000012390 contributor: fullname: JS Park – volume: 125 start-page: 505 year: 2019 ident: 86805_CR30 publication-title: Environ. Int. doi: 10.1016/j.envint.2018.11.037 contributor: fullname: MK Chung – volume: 167 start-page: 78 year: 2018 ident: 86805_CR8 publication-title: Environ. Res. doi: 10.1016/j.envres.2018.07.004 contributor: fullname: MM Smarr – volume: 50 start-page: 831 year: 2014 ident: 86805_CR26 publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2013.11.035 contributor: fullname: C Le Cornet – volume: 9 start-page: 3409 year: 2019 ident: 86805_CR18 publication-title: Sci. Rep. doi: 10.1038/s41598-019-39913-9 contributor: fullname: RN Sumner |
SSID | ssj0000529419 |
Score | 2.427046 |
Snippet | In humans and dogs, a temporal decline in semen quality and increased incidence of testicular cancer is hypothesised to be associated with exposure to... Abstract In humans and dogs, a temporal decline in semen quality and increased incidence of testicular cancer is hypothesised to be associated with exposure to... |
SourceID | doaj pubmedcentral proquest crossref pubmed springer |
SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 7361 |
SubjectTerms | 631/136 692/420 704/172 Anthropogenic factors Cell proliferation Chemicals Ethers Fetuses Germ cells Humanities and Social Sciences multidisciplinary PCB Polybrominated diphenyl ethers Polychlorinated biphenyls Reproductive health Science Science (multidisciplinary) Testes Testicular cancer |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1JT9wwFLYqJKReUAsFUgbkAzca4SV27GNbDUKV4MRIc7MSL4BEQ8Wkh_n3PNuZjUW99JbEVrx8z3rPb0XoFDAWATh7Sbmw8YKiy6YOsnSBWN5YXdUpUPjqWl5Oql9TMV0r9RV9wnJ64Lxx57GKSiOFragXFaOyrayuvQ6aKh2czWG-hK1dpnJWb6YrqocoGcLV-Qw4VYwmY7RUUhFRzjc4UUrY_5aU-dpZ8oXFNDGii09oZ5Ag8fc888_og-920XauKTnfQ_14FboG3eyQEGCG7zvsHm9xHxWcMwzTiQp7nAwF-DaXQo9uGQ846_Nx0zn8u5njFh4HDL3DUW-Lk4kdXmI54zTsFzS5GN_8vCyH0gqlFZr3Ja1bKR1x0jfe-1aA3MSIZZwHaUms0meJBlFJK-qZs0HWrg7UB6ZJ8MK1mu-jre6x84cIu2CtFA0IPjJU2gUdOb7VCn7WOGlFgc4W22z-5AwaJlm-uTIZFAOgmASKmRfoR0Ri2TNmv04fgCbMQBPmXzRRoNECRzMcyZkBWS_Wb1Acmg8ypMtROAeSVZQWqN4Ae2Mamy3d_V1Kxg0cXoLMV6BvC7JYDfn-Mr_-j2UeoY8s0nPyIxqhrf7prz8GEalvT9JpeAZqng5e priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIlLRXkGWuQDN7Aax_HrhAC1qpDgRKW9WYkfSyXIliY97L9nxvHuannd8rA8Tr5xZjJPQl4DxjKBZGdcSI8_KJZ1OikWUu1F522rc6Lw5y_q4rL9tJCLYnAbS1jl5puYP9Rh5dFGfgqiGsvvG2HeXf9k2DUKvaulhcZdco83IMqBn_VCb20s6MVquS25MrUwpyPIK8wpazgzCqZj6z15lMv2_03X_DNk8je_aRZH5w_JYdEj6fsZ-CNyJw6PyP25s-T6MZnOdglsMMyXsgAjvRpoWC3phGbOkcJy0GxPs7uALueG6Bic8Z3OVn3aDYH-6Na0h8OCZAwUrbc0O9rhBJsaZ7JPyOX52dePF6w0WGBeWjExrnulQh1U7GKMvQTtqal9I0RSvsZefb62oDBZw2MTfFI66MRjamydogy9FU_JwbAa4nNCQ_JeyQ7UH5VaG5JFue-tgcm6oLysyJvNa3bXcx0Nl_3fwrgZFAeguAyKW1fkAyKxHYk1sPOF1c3SlS3lsL9Op6RveZRtw1UP9HS0yXJjU_CmIscbHF3ZmKPbsVFFns2QbqkIAYxrOK-I3gN7bxn7d4arb7kkN8h5BZpfRd5u2GJH8t-P-eL_K3xJHjTIqTlO6JgcTDe38QRUoKl_lfn8F6l4Bmo priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1Lb9QwEB6VIlAviDeBgnzgBoHYjh37gBCgVhVSObFSb1bix1KpzcJukMi_Z2wnrRa2tyROYjvfRPP5MfMBvEaMRUDPXlIubByg6LJtgixdqCxvra6bFCh8-k2eLOqvZ-JsD2a5o-kDbnYO7aKe1GJ98e7Pr_Ej_vAfcsi4er9BJxQDxRgtlVSVKMdbcJuhZ4xbvE4nup9zfTNdUz3Fzux-9ADuco4dUJRuuaqU0X8XDf1_N-U_S6rJUx3fh3sTxSSfsk08gD3fP4Q7WXRyfATD0XVsG95mp4wBG3LeE7dakiHOgG4INifO6JO0kkCWWSs97tu4IHnCn7S9I5ftSDo8nED2jsSJXZLW4PEk6h2nah_D4vjo-5eTctJeKK3QfChp00npKid9673vBBIrVlnGeZC2ijJ-ttLIpbSinjkbZOOaQH1gugpeuE7zJ7Dfr3r_DIgL1krRIjOSodYu6EgJrFb4stZJKwp4M39m8zOn2DBpaZwrk_ExiI9J-JixgM8Rias7Y3rsdGG1XprpbzNReqeVwtbUi5pR2WF9jddBU6WDs6qAwxlHM5ucQTIYBR4Ux-KnGdKrWmaTKKDZAnurGdsl_fmPlK0bKYBEUljA29ksrqu8uZvPb2zCCzhg0V7T7qFD2B_Wv_1LJEZD9ypZ-18cwQnE priority: 102 providerName: Scholars Portal – databaseName: Springer Nature OA Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Nb9QwEB1BERIXVCiFQKl84EYj4jh27CNddbWqBCcq7c1K_LFdCdKKDYf998w42a0Cy4FbEjuxkzfWvMx4ZgA-IMYyombPuZCOflBM3tRR5T4WTjTOVHUKFP7yVS1uquulXI5pcigWZuK_F_rTBhUMBYGVPNdKFzLfPoYnqINrkuaZmu3tKeSxqrgZ42IO3zrRPSlF_yFe-ff2yD98pEn1zI_h-cgZ2ecB5BfwKHQv4elQRXJ7Av3VQ7AadnNjCoANW3fM361YTybNDcPpkImeJdcAWw3Fz2kjxnc2WPBZ03n2o9myFg9H1IJnZKllyamOJ1TAOA37Cm7mV99mi3wsppA7aUSf87pVyhdehSaE0EpkSmXhSiGicgXV5XOFQXJkNA-ld1HVvo48xNIUMUjfGnEKR91dF94A89E5JRukOipWxkdDOt4ZjQ9rvHIyg4-7z2zvh5wZNvm6hbYDKBZBsQkUu83gkpDY96R81-kCioEdl4-lWjqNkq7iQVYlVy2OVwcTDdcmeqczONvhaMdFuLHI7qhigxbY_HqAdD-KECikmvMM6gnYk2lMW7r1bUq_jTpdIcvL4GInFg9D_vs13_5f93fwrCTJTXuEzuCo__krvEf607fnSe5_A4KQ_9s priority: 102 providerName: Springer Nature |
Title | Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology |
URI | https://link.springer.com/article/10.1038/s41598-021-86805-y https://www.ncbi.nlm.nih.gov/pubmed/33795811 https://www.proquest.com/docview/2507805838 https://pubmed.ncbi.nlm.nih.gov/PMC8016893 https://doaj.org/article/3720a65c41e54216b4c97e9f9189fdc8 |
Volume | 11 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07b9swED4kKVpkKfpMlaYGh26tYlEUKXJsDAdBAQdB0QDeCIkP10AsB7E6-N_nSElJ3cfSRZBEQkfpO-qOx3sAfESMuUfJnlLGTVigqLQqvUitzwyrjCrKGCg8uxQX18XXOZ_vAR9iYaLTvqmXp83N6rRZ_oi-lbcrMx78xMZXswn-VQXK2fE-7KP4_WWJ3iX0zlVBVR8gkzE53qCQCoFkOU2lkBlPt4fwjDEcpaR0Rx7FtP1_0zX_dJn8bd80iqPzF_C81yPJl268L2HPNa_gaVdZcvsa2uljABt2M31agA1ZNsSuF6QNZs4NweEEsz2J2wVk0RVED84ZN6Sz6pOqsWRVbUmNpz2SzpJgvSVxox0vQlHjSPYNXJ9Pv08u0r7AQmq4Ym1Ky1oIm1nhKudczVF7yjOTM-aFyUKtPpMpVJiUpC63xovSlp46n6vMO25rxd7CQbNu3Dsg1hsjeIXqj_CFsl4FuW-UxIdVVhiewKfhM-vbLo-GjvvfTOoOH4346IiP3iZwFpB46BlyYMcb67uF7jlBh_o6leCmoI4XORU10iud8opK5a2RCZwMOOp-Ym40anyhioNk2HzUQfpAZWCJBModsHeGsduCHBpTcvccmcDngS0eSf77NY__m9B7OMwDP0cXohM4aO9-ug-oHbX1COfEvBzBk7Pp5dU3vJqIyShaGvA4K-QozpZ7r0QUmA |
link.rule.ids | 230,314,727,780,784,864,885,2102,12056,21388,24318,27924,27925,31719,33744,41120,42189,43310,43805,51576,53791,53793,73745,74302 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVgguiDeBAj5wg6hxHDv2CVG01QLtCqFW6s1K_NhWgmxpwmH_PWPHu6vldcvDyTj5xpnJPAFeI8bco2TPKeMm_KCovKm9yK0vDGuMquqYKHwyF7Oz6tM5P08Gtz6FVa6_ifFDbZcm2MgPUFSH8vuSyXdXP_LQNSp4V1MLjZuwFyqn8wnsHU7nX75urCzBj1VRlbJlCiYPepRYIauspLkUeEm-2pFIsXD_37TNP4Mmf_OcRoF0dA_uJk2SvB-hvw83XPcAbo29JVcPYZhuU9hwmEmFAXpy2RG7XJAhGDp7gtMJhnsSHQZkMbZED-EZ38ho1ydNZ8n3ZkVa3ExYOkuC_ZZEVzvuhLbGkewjODuann6Y5anFQm64YkNO61YIW1jhGudcy1F_KgtTMuaFKUK3PlMoVJmUpK60xova1p46X6rCO25bxR7DpFt27ikQ640RvEEFSPhKWa-C5DdK4s0aKwzP4M36NeursZKGjh5wJvUIikZQdARFrzI4DEhsRoYq2PHA8nqh06LSocNOI7ipqONVSUWL9GqnvKJSeWtkBvtrHHVamr3eMlIGT0ZIN1QYQ9aVlGZQ74C9M43dM93lRSzKjZJeoO6Xwds1W2xJ_vsxn_1_hq_g9uz05Fgff5x_fg53ysC1MWpoHybD9U_3AhWioX2ZuP4XmrEKwA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVqBeEO8GCvjADaLGcezYJ0RhV-W1qhCVerMSP5ZKkC1NOOy_Z-x4d7W8bnlYHiffODOZJ8BzxJh7lOw5ZdyEHxSVN7UXufWFYY1RVR0ThT_NxclZ9f6cn6f4pz6FVa6_ifFDbZcm2MiPUFSH8vuSySOfwiJO385eXf7IQwep4GlN7TSuwx5KxaKcwN7xdH76eWNxCT6tiqqUOVPgRD1Kr5BhVtJcCpw8X-1Ip1jE_2-a558BlL95UaNwmt2GW0mrJK9HNrgD11x3F26MfSZX92CYbtPZcJhJRQJ6ctERu1yQIRg9e4LLCUZ8Ep0HZDG2Rw-hGt_IaOMnTWfJ92ZFWjxMuDpLgi2XRLc7noQWx5HsfTibTb-8OclTu4XccMWGnNatELawwjXOuZajLlUWpmTMC1OEzn2mUKg-KUldaY0Xta09db5UhXfctoo9gEm37NwBEOuNEbxBZUj4SlmvghZglMTJGisMz-DF-jXry7Gqho7ecCb1CIpGUHQERa8yOA5IbEaGitjxwvJqodMG06HbTiO4qajjVUlFi_Rqp7yiUnlrZAaHaxx12qa93jJVBg9HSDdUGEM2lpRmUO-AvbOM3TvdxddYoBulvkA9MIOXa7bYkvz3Yz76_wqfwU1keP3x3fzDY9gvA9PGAKJDmAxXP90T1I2G9mli-l_4Vw7t |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Environmental+chemicals+in+dog+testes+reflect+their+geographical+source+and+may+be+associated+with+altered+pathology&rft.jtitle=Scientific+reports&rft.au=Sumner%2C+Rebecca+N&rft.au=Byers%2C+Andrew&rft.au=Zhang%2C+Zulin&rft.au=Agerholm%2C+Jorgen+S&rft.date=2021-04-01&rft.eissn=2045-2322&rft.volume=11&rft.issue=1&rft.spage=7361&rft_id=info:doi/10.1038%2Fs41598-021-86805-y&rft_id=info%3Apmid%2F33795811&rft.externalDocID=33795811 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |