Comparison of micro- vs. nanostructured colloidal gelatin gels for sustained delivery of osteogenic proteins: Bone morphogenetic protein-2 and alkaline phosphatase

• Published in: Biomaterials Vol. 33; no. 33; pp. 8695 - 8703
• Main Authors: Wang, Huanan, Boerman, Otto C., Sariibrahimoglu, Kemal, Li, Yubao, Jansen, John A., Leeuwenburgh, Sander C.G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.11.2012
• Subjects: Advanced Basic Science; alkaline phosphatase; Alkaline Phosphatase - administration & dosage; Alkaline Phosphatase - chemistry; biodegradability; biopharmaceuticals; Bone Morphogenetic Protein 2 - administration & dosage; Bone Morphogenetic Protein 2 - chemistry; cohesion; Colloidal gels; colloidal properties; Controlled delivery; crosslinking; Dentistry; drug carriers; gel strength; Gelatin; Gelatin - chemistry; medicine; Microsphere; Microspheres; Nanosphere; Nanospheres; Nanostructures - chemistry; particle size; polymers; radiolabeling; rheology; Self-healing; viscoelasticity; Controlled delivery; Nanosphere; Self-healing; Microsphere; Gelatin; Colloidal gels

Colloidal gels have recently emerged as a promising new class of materials for regenerative medicine by employing micro- and nanospheres as building blocks to assemble into integral scaffolds. To this end, physically crosslinked particulate networks are formed that are injectable yet cohesive. By va...