Sodium selenite promotes neurological function recovery after spinal cord injury by inhibiting ferroptosis

• Published in: Neural regeneration research Vol. 17; no. 12; pp. 2702 - 2709
• Main Authors: Chen, Yi-Xin, Zuliyaer, Talifu, Liu, Bin, Guo, Shuang, Yang, De-Gang, Gao, Feng, Yu, Yan, Yang, Ming-Liang, Du, Liang-Jie, Li, Jian-Jun
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.12.2022; Medknow Publications & Media Pvt. Ltd; Center of Neural Injury and Repair,Beijing Institute for Brain Disorders,Beijing,China; Beijing Key Laboratory of Neural Injury and Rehabilitation,Beijing,China; China Rehabilitation Science Institute,Beijing,China; Beijing Key Laboratory of Neural Injury and Rehabilitation,Beijing,China%Department of Spine Surgery,Hunan Provincial People's Hospital(The First Affiliated Hospital of Hunan Normal University),Changsha,Hunan Province,China%China Rehabilitation Science Institute,Beijing,China; Department of Spinal and Neural Functional Reconstruction,China Rehabilitation Research Center,Beijing,China; School of Rehabilitation Medicine,Capital Medical University,Beijing,China; Department of Rehabilitation Medicine,Xiangya Hospital of Central South University,Changsha,Hunan Province,China%School of Rehabilitation Medicine,Capital Medical University,Beijing,China; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Ferroptosis; ferroptosis; glutathione peroxidase 4; glutathione; iron; lipid peroxidation; neural regeneration; secondary injury; sodium selenite; specificity protein 1; spinal cord injury; Proteins; Sodium; Spinal cord injuries; spinal cord injury; glutathione peroxidase 4; ferroptosis; neural regeneration; secondary injury; sodium selenite; specificity protein 1; glutathione; iron; lipid peroxidation

Ferroptosis is a recently discovered form of iron-dependent cell death, which occurs during the pathological process of various central nervous system diseases or injuries, including secondary spinal cord injury. Selenium has been shown to promote neurological function recovery after cerebral hemorr...