n-3 PUFA Esterified to Glycerol or as Ethyl Esters Reduce Non-Fasting Plasma Triacylglycerol in Subjects with Hypertriglyceridemia: A Randomized Trial

• Published in: Lipids Vol. 50; no. 2; pp. 165 - 175
• Main Authors: Hedengran, Anne, Szecsi, Pal B., Dyerberg, Jørn, Harris, William S., Stender, Steen
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2015; Springer Nature B.V
• Subjects: Aged; Biomedical and Life Sciences; Cardiovascular diseases; Cholesterol; Docosahexaenoic acids; Double-Blind Method; Eicosapentaenoic acid; erythrocytes; esterification; Esters; Esters - chemistry; Esters - therapeutic use; fasting; Fasting - blood; Fatty Acids, Omega-3 - chemistry; Fatty Acids, Omega-3 - therapeutic use; Female; Glycerides - chemistry; Glycerides - therapeutic use; glycerol; Health risks; Heart rate; high density lipoprotein; Humans; hypertriglyceridemia; Hypertriglyceridemia - blood; Hypertriglyceridemia - diet therapy; Life Sciences; Lipidology; Lipoprotein‐associated phospholipase A2; Male; Medical Biochemistry; Medicinal Chemistry; Microbial Genetics and Genomics; Middle Aged; Neurochemistry; Non‐fasting; Nutrition; n‐3 Polyunsaturated fatty acid; omega-3 fatty acids; Omega‐3 acylglycerol; Omega‐3 ethyl ester; Original Article; phospholipase A2; Polyunsaturated fatty acids; risk; Triacylglycerols; Triglycerides - blood; Omega-3 acylglycerol; Heart rate; n-3 Polyunsaturated fatty acid; Lipoprotein-associated phospholipase A2; Omega-3 ethyl ester; Docosahexaenoic acids; Non-fasting; Eicosapentaenoic acid; Triacylglycerols

To date, treatment of hypertriglyceridemia with long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) has been investigated solely in fasting and postprandial subjects. However, non-fasting triacylglycerols are more strongly associated with risk of cardiovascular disease. The objective of this study...