The novel adipocytokine visfatin exerts direct cardioprotective effects

• Published in: Journal of cellular and molecular medicine Vol. 12; no. 4; pp. 1395 - 1403
• Main Authors: Lim, Shiang Y., Davidson, Sean M., Paramanathan, Ajeev J., Smith, Christopher C. T., Yellon, Derek M., Hausenloy, Derek J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2008; John Wiley & Sons, Inc
• Subjects: 1-Phosphatidylinositol 3-kinase; Adipokines - administration & dosage; Adipokines - pharmacology; AKT protein; Androstadienes - pharmacology; Animals; Apoptosis - drug effects; Blood pressure; Butadienes - pharmacology; Cardiomyocytes; cardioprotection; Cardiotonic Agents - pharmacology; Cardiovascular disease; Cell death; Cell Survival - drug effects; Coronary vessels; Cytokines; Enzyme Activation - drug effects; Extracellular signal-regulated kinase; Extracellular Signal-Regulated MAP Kinases - metabolism; Glucose; Heart; Heart attacks; Hemodynamics - drug effects; Hypoxia; Insulin; ischaemia; Ischemia; Ketamine; Kinases; Male; MAP kinase; MAP Kinase Kinase Kinases - metabolism; Membrane permeability; Mice; Mice, Inbred C57BL; Microscopy; Mitochondrial Membrane Transport Proteins - metabolism; Mitochondrial permeability transition pore; Myocardial infarction; Myocardial Infarction - enzymology; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocardial Reperfusion Injury - enzymology; Myocardial Reperfusion Injury - physiopathology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - pathology; Nicotinamide Phosphoribosyltransferase - administration & dosage; Nicotinamide Phosphoribosyltransferase - pharmacology; Nitriles - pharmacology; Ostomy; Oxidation; Oxidative stress; Oxygen - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Protocol; Reperfusion; Rodents; Signal transduction; Studies; Time Factors; Veins & arteries; Ventricle; visfatin; Wortmannin; United Kingdom > UK; United States > US

Visfatin is an adipocytokine capable of mimicking the glucose‐lowering effects of insulin and activating the pro‐survival kinases phosphatidylinositol‐3‐OH kinase (PI3K)‐protein kinase B (Akt) and mitogen‐activated protein kinase kinase 1 and 2 (MEK1/2)‐extracellular signal‐regulated kinase 1 and 2...