Involvement of DNA methylation in regulating rat Prop1 gene expression during pituitary organogenesis

• Published in: Journal of Reproduction and Development Vol. 63; no. 1; pp. 37 - 44
• Main Authors: NISHIHARA, Hiroto, YOSHIDA, Saishu, KANNO, Naoko, NISHIMURA, Naoto, UEHARU, Hiroki, OHGANE, Jun, KATO, Takako, KATO, Yukio
• Format: Journal Article
• Language: English
• Published: Japan THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT 2017; Japan Science and Technology Agency; The Society for Reproduction and Development
• Subjects: Animals; Bisulfite; Computational Biology; CpG Islands; Deoxyribonucleic acid; DNA; DNA - metabolism; DNA Methylation; DNA sequencing; Embryos; Epigenesis, Genetic; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Developmental; Homeodomain Proteins - metabolism; Liver - metabolism; Male; Organogenesis; Original; Pituitary; Pituitary gland; Pituitary Gland - embryology; Pituitary Gland - physiology; PROP1; Prophet of pit-1 protein; Rat; Rats; Rats, Wistar; Temperature

PROP1 is a pituitary specific transcription factor that plays a crucial role in pituitary organogenesis. The Prop1 shows varied expression patterns that promptly emerge and then fade during the early embryonic period. However, the regulatory mechanisms governing Prop1 expression remain unclear. Here...