Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell‐Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury

• Published in: Stem cells translational medicine Vol. 8; no. 3; pp. 260 - 270
• Main Authors: Kojima, Kota, Miyoshi, Hiroyuki, Nagoshi, Narihito, Kohyama, Jun, Itakura, Go, Kawabata, Soya, Ozaki, Masahiro, Iida, Tsuyoshi, Sugai, Keiko, Ito, Shuhei, Fukuzawa, Ryuji, Yasutake, Kaori, Renault‐Mihara, Francois, Shibata, Shinsuke, Matsumoto, Morio, Nakamura, Masaya, Okano, Hideyuki
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2019; Oxford University Press
• Subjects: Ablation; Animals; Apoptosis; Carcinogenesis - pathology; Cell cycle; Cell Differentiation - physiology; Cells, Cultured; Cytotoxicity; Diabetes mellitus; Disease Models, Animal; Enabling Technologies for Cell‐Based Clinical Translation; Female; Genes; Herpes simplex; Herpes simplex virus thymidine kinase; Herpes viruses; Human induced pluripotent stem cell‐derived neural stem/progenitor cell; Humans; Induced Pluripotent Stem Cells - cytology; Medical research; Mice; Mice, Inbred NOD; Mice, SCID; Neural stem cells; Neural Stem Cells - cytology; Neurons - physiology; Pharmaceutical industry; Pluripotency; Progenitor cells; Recovery of Function - physiology; Scientific equipment and supplies industry; Spinal Cord - physiology; Spinal cord injuries; Spinal Cord Injuries - therapy; Spinal cord injury; Stem cell research; Stem cell therapy; Stem cell transplantation; Stem Cell Transplantation - methods; Stem cells; Suicide; Suicide gene; Suicide genes; Tetracycline; Tetracyclines; Thymidine; Thymidine kinase; Transplantation; Tumorigenesis; Tumors; United States; Japan; Germany; Human induced pluripotent stem cell-derived neural stem/progenitor cell; Stem cell therapy; Spinal cord injury; Suicide gene; Herpes simplex virus thymidine kinase

Tumorigenesis is an important problem that needs to be addressed in the field of human stem/progenitor cell transplantation for the treatment of subacute spinal cord injury (SCI). When certain “tumorigenic” cell lines are transplanted into the spinal cord of SCI mice model, there is initial improvem...