Regeneration of Amputated Zebrafish Fin Rays from De Novo Osteoblasts

• Published in: Developmental cell Vol. 22; no. 4; pp. 879 - 886
• Main Authors: Singh, Sumeet Pal, Holdway, Jennifer E., Poss, Kenneth D.
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Inc 17.04.2012; Cell Press
• Subjects: Amputation, Surgical; Animal Fins - cytology; Animal Fins - metabolism; Animals; Animals, Genetically Modified; Biological and medical sciences; Bone and Bones - cytology; Bone and Bones - metabolism; Cell Differentiation; Cell differentiation, maturation, development, hematopoiesis; Cell Lineage; Cell physiology; Danio rerio; Extremities - growth & development; Flow Cytometry; Freshwater; Fundamental and applied biological sciences. Psychology; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Molecular and cellular biology; Osteoblasts - cytology; Osteoblasts - metabolism; Regeneration - physiology; Zebrafish; Osteoarticular system; Regeneration; Vertebrata; Brachydanio rerio; Pisces; Development; Osteoblast; Bone; De novo

Determining the cellular source of new skeletal elements is critical for understanding appendage regeneration in amphibians and fish. Recent lineage-tracing studies indicated that zebrafish fin ray bone regenerates through the dedifferentiation and proliferation of spared osteoblasts, with limited i...