Germline mutational spectrum in Armenian breast cancer patients suspected of hereditary breast and ovarian cancer

• Published in: Human genome variation Vol. 8; no. 1; p. 9
• Main Authors: Moradian, Mike M., Babikyan, Davit T., Markarian, Sione, Petrosyan, Jonny G., Avanesian, Nare, Arutunyan, Tereza, Sarkisian, Tamara F.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.02.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/208/68; 692/420/2489/68; Biomedical and Life Sciences; Biomedicine; BRCA1 protein; BRCA2 protein; Breast cancer; Gene Expression; Gene Function; Gene Therapy; Genes; Genetic diversity; Genetic screening; Heredity; Human Genetics; Molecular Medicine; Ovarian cancer; Patients

Hereditary breast and ovarian cancer (HBOC) can be identified by genetic testing of cancer-causing genes. In this study, we identified a spectrum of genetic variations among 76 individuals of Armenian descent either with a family history of cancer or breast cancer before the age of 40. We screened 7...