Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2

• Published in: PLoS pathogens Vol. 20; no. 3; p. e1011794
• Main Authors: Ware, Brian C., Parks, M. Guston, da Silva, Mariana O. L., Morrison, Thomas E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.03.2024; Public Library of Science (PLoS)
• Subjects: Analysis; Ankle; Antigen presentation; Antigens; Antiviral agents; Antiviral drugs; Biology and life sciences; CD8 antigen; Cell surface; Chikungunya fever; Chikungunya virus; Dosage and administration; Efficiency; Endoplasmic reticulum; Epidemics; Epitopes; Fibroblasts; Flow cytometry; Fluorescence; Genomes; Genomics; Health aspects; Immune response; Immunosurveillance; Infection; Infections; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Medicine and Health Sciences; Methyltransferase; Mutation; Nucleic acids; Peptides; Prevention; Proteins; Research and Analysis Methods; Risk factors; Signs and symptoms; Surveillance; T cell receptors; T cells; Vector-borne diseases; Venus; Venus (Planet); Viral infections; Virus diseases; Viruses; β2 Microglobulin; Brazil

Infection by chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes severe polyarthralgia and polymyalgia, which can last in some people for months to years. Chronic CHIKV disease signs and symptoms are associated with the persistence of viral nucleic acid and antigen in tissues. Like humans...