Intra-cameral level of ganciclovir gel, 0.15% following topical application for cytomegalovirus anterior segment infection: A pilot study

• Published in: PloS one Vol. 13; no. 1; p. e0191850
• Main Authors: Waduthantri, Samanthila, Zhou, Lei, Chee, Soon-Phaik
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2018; Public Library of Science (PLoS)
• Subjects: Administration, Ophthalmic; Adult; Aged; Aged, 80 and over; Anterior chamber; Anterior Eye Segment - pathology; Antiviral Agents - administration & dosage; Antiviral drugs; Aqueous humour; Biology and Life Sciences; Chromatography; Chromatography, Liquid; Cornea; Correlation; Cytomegalovirus; Cytomegalovirus - genetics; Cytomegalovirus Infections - drug therapy; Female; Ganciclovir; Ganciclovir - administration & dosage; Health services; Herpes viruses; High performance liquid chromatography; Humans; Infections; Laboratories; Levels; Liquid chromatography; Male; Mass spectrometry; Mass spectroscopy; Medicine and Health Sciences; Middle Aged; Patients; Physical Sciences; Pilot Projects; Polymerase chain reaction; Prospective Studies; Real-Time Polymerase Chain Reaction; Research and Analysis Methods; Scientific imaging; Tandem Mass Spectrometry; Tears; Topical application; Transplants & implants; Uveitis; France; Singapore

To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection. Non-randomized, prospective, interventional clinical study. Patients with active CMV anterior segment infection seen at Singapore Nation...