Intra-cameral level of ganciclovir gel, 0.15% following topical application for cytomegalovirus anterior segment infection: A pilot study
To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection. Non-randomized, prospective, interventional clinical study. Patients with active CMV anterior segment infection seen at Singapore Nation...
Saved in:
| Published in | PloS one Vol. 13; no. 1; p. e0191850 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
01.01.2018
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0191850 |
Cover
Loading…
| Abstract | To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection.
Non-randomized, prospective, interventional clinical study.
Patients with active CMV anterior segment infection seen at Singapore National Eye Centre, confirmed by positive CMV real time PCR (RT-PCR) of the aqueous humor, that had not been treated with any form of ganciclovir in the preceding 1 month were recruited. They were treated with ganciclovir gel, 0.15% 1cc 5 times a day. Following 6 weeks of treatment, CMV load in the aqueous humor was measured using CMV RT-PCR and the ganciclovir drug levels in tears and aqueous humor were measured using high-performance liquid chromatography-mass spectrometry. The clinical features of the disease activity and the central corneal thickness (CCT) were recorded at the baseline and post-treatment.
There were 29 eyes of 29 patients, of which 23 eyes had CMV anterior uveitis and 6 eyes had CMV endotheliitis. At the end of week 6, 26 eyes had undetectable CMV titre in the aqueous humor and no anterior chamber (AC) activity. Two patients had an increased CMV titre and increased AC inflammation. Both of these patients were non-compliant with the treatment. One patient had a reduced CMV titre in the aqueous humor with minimal AC inflammation. The mean ganciclovir concentration in the aqueous humor and the tears were 17.4 ± 30.6 ng/ml and 20,420.9 ± 33,120.8 ng/ml respectively. Mean CCT was 552.2 ± 42.3 microns. There was a weak correlation between the ganciclovir concentration in the aqueous humor and CCT (Spearmen's r = + 0.42, p = 0.025). There was no significant correlation between the ganiclovir concentration in the tears and CCT (Spearmen's r = + 0.39, p = 0.11).
Ganciclovir levels in the aqueous humor was below the 50% inhibitory dose (ID50) for CMV replication, following topical application of the ganciclovir gel, 0.15%.
SingHealth Centralized Institutional Review Board, Singapore; R733/17/2010, ClinicalTrials.gov; NCT01647529. |
|---|---|
| AbstractList | To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection.
Non-randomized, prospective, interventional clinical study.
Patients with active CMV anterior segment infection seen at Singapore National Eye Centre, confirmed by positive CMV real time PCR (RT-PCR) of the aqueous humor, that had not been treated with any form of ganciclovir in the preceding 1 month were recruited. They were treated with ganciclovir gel, 0.15% 1cc 5 times a day. Following 6 weeks of treatment, CMV load in the aqueous humor was measured using CMV RT-PCR and the ganciclovir drug levels in tears and aqueous humor were measured using high-performance liquid chromatography-mass spectrometry. The clinical features of the disease activity and the central corneal thickness (CCT) were recorded at the baseline and post-treatment.
There were 29 eyes of 29 patients, of which 23 eyes had CMV anterior uveitis and 6 eyes had CMV endotheliitis. At the end of week 6, 26 eyes had undetectable CMV titre in the aqueous humor and no anterior chamber (AC) activity. Two patients had an increased CMV titre and increased AC inflammation. Both of these patients were non-compliant with the treatment. One patient had a reduced CMV titre in the aqueous humor with minimal AC inflammation. The mean ganciclovir concentration in the aqueous humor and the tears were 17.4 ± 30.6 ng/ml and 20,420.9 ± 33,120.8 ng/ml respectively. Mean CCT was 552.2 ± 42.3 microns. There was a weak correlation between the ganciclovir concentration in the aqueous humor and CCT (Spearmen's r = + 0.42, p = 0.025). There was no significant correlation between the ganiclovir concentration in the tears and CCT (Spearmen's r = + 0.39, p = 0.11).
Ganciclovir levels in the aqueous humor was below the 50% inhibitory dose (ID50) for CMV replication, following topical application of the ganciclovir gel, 0.15%.
SingHealth Centralized Institutional Review Board, Singapore; R733/17/2010, ClinicalTrials.gov; NCT01647529. PurposeTo investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection.DesignNon-randomized, prospective, interventional clinical study.MethodsPatients with active CMV anterior segment infection seen at Singapore National Eye Centre, confirmed by positive CMV real time PCR (RT-PCR) of the aqueous humor, that had not been treated with any form of ganciclovir in the preceding 1 month were recruited. They were treated with ganciclovir gel, 0.15% 1cc 5 times a day. Following 6 weeks of treatment, CMV load in the aqueous humor was measured using CMV RT-PCR and the ganciclovir drug levels in tears and aqueous humor were measured using high-performance liquid chromatography-mass spectrometry. The clinical features of the disease activity and the central corneal thickness (CCT) were recorded at the baseline and post-treatment.ResultsThere were 29 eyes of 29 patients, of which 23 eyes had CMV anterior uveitis and 6 eyes had CMV endotheliitis. At the end of week 6, 26 eyes had undetectable CMV titre in the aqueous humor and no anterior chamber (AC) activity. Two patients had an increased CMV titre and increased AC inflammation. Both of these patients were non-compliant with the treatment. One patient had a reduced CMV titre in the aqueous humor with minimal AC inflammation. The mean ganciclovir concentration in the aqueous humor and the tears were 17.4 ± 30.6 ng/ml and 20,420.9 ± 33,120.8 ng/ml respectively. Mean CCT was 552.2 ± 42.3 microns. There was a weak correlation between the ganciclovir concentration in the aqueous humor and CCT (Spearmen's r = + 0.42, p = 0.025). There was no significant correlation between the ganiclovir concentration in the tears and CCT (Spearmen's r = + 0.39, p = 0.11).ConclusionGanciclovir levels in the aqueous humor was below the 50% inhibitory dose (ID50) for CMV replication, following topical application of the ganciclovir gel, 0.15%.Trial registrationSingHealth Centralized Institutional Review Board, Singapore; R733/17/2010, ClinicalTrials.gov; NCT01647529. Purpose To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection. Design Non-randomized, prospective, interventional clinical study. Methods Patients with active CMV anterior segment infection seen at Singapore National Eye Centre, confirmed by positive CMV real time PCR (RT-PCR) of the aqueous humor, that had not been treated with any form of ganciclovir in the preceding 1 month were recruited. They were treated with ganciclovir gel, 0.15% 1cc 5 times a day. Following 6 weeks of treatment, CMV load in the aqueous humor was measured using CMV RT-PCR and the ganciclovir drug levels in tears and aqueous humor were measured using high-performance liquid chromatography-mass spectrometry. The clinical features of the disease activity and the central corneal thickness (CCT) were recorded at the baseline and post-treatment. Results There were 29 eyes of 29 patients, of which 23 eyes had CMV anterior uveitis and 6 eyes had CMV endotheliitis. At the end of week 6, 26 eyes had undetectable CMV titre in the aqueous humor and no anterior chamber (AC) activity. Two patients had an increased CMV titre and increased AC inflammation. Both of these patients were non-compliant with the treatment. One patient had a reduced CMV titre in the aqueous humor with minimal AC inflammation. The mean ganciclovir concentration in the aqueous humor and the tears were 17.4 ± 30.6 ng/ml and 20,420.9 ± 33,120.8 ng/ml respectively. Mean CCT was 552.2 ± 42.3 microns. There was a weak correlation between the ganciclovir concentration in the aqueous humor and CCT (Spearmen's r = + 0.42, p = 0.025). There was no significant correlation between the ganiclovir concentration in the tears and CCT (Spearmen's r = + 0.39, p = 0.11). Conclusion Ganciclovir levels in the aqueous humor was below the 50% inhibitory dose (ID50) for CMV replication, following topical application of the ganciclovir gel, 0.15%. Trial registration SingHealth Centralized Institutional Review Board, Singapore; R733/17/2010, ClinicalTrials.gov; NCT01647529. To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection.PURPOSETo investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection.Non-randomized, prospective, interventional clinical study.DESIGNNon-randomized, prospective, interventional clinical study.Patients with active CMV anterior segment infection seen at Singapore National Eye Centre, confirmed by positive CMV real time PCR (RT-PCR) of the aqueous humor, that had not been treated with any form of ganciclovir in the preceding 1 month were recruited. They were treated with ganciclovir gel, 0.15% 1cc 5 times a day. Following 6 weeks of treatment, CMV load in the aqueous humor was measured using CMV RT-PCR and the ganciclovir drug levels in tears and aqueous humor were measured using high-performance liquid chromatography-mass spectrometry. The clinical features of the disease activity and the central corneal thickness (CCT) were recorded at the baseline and post-treatment.METHODSPatients with active CMV anterior segment infection seen at Singapore National Eye Centre, confirmed by positive CMV real time PCR (RT-PCR) of the aqueous humor, that had not been treated with any form of ganciclovir in the preceding 1 month were recruited. They were treated with ganciclovir gel, 0.15% 1cc 5 times a day. Following 6 weeks of treatment, CMV load in the aqueous humor was measured using CMV RT-PCR and the ganciclovir drug levels in tears and aqueous humor were measured using high-performance liquid chromatography-mass spectrometry. The clinical features of the disease activity and the central corneal thickness (CCT) were recorded at the baseline and post-treatment.There were 29 eyes of 29 patients, of which 23 eyes had CMV anterior uveitis and 6 eyes had CMV endotheliitis. At the end of week 6, 26 eyes had undetectable CMV titre in the aqueous humor and no anterior chamber (AC) activity. Two patients had an increased CMV titre and increased AC inflammation. Both of these patients were non-compliant with the treatment. One patient had a reduced CMV titre in the aqueous humor with minimal AC inflammation. The mean ganciclovir concentration in the aqueous humor and the tears were 17.4 ± 30.6 ng/ml and 20,420.9 ± 33,120.8 ng/ml respectively. Mean CCT was 552.2 ± 42.3 microns. There was a weak correlation between the ganciclovir concentration in the aqueous humor and CCT (Spearmen's r = + 0.42, p = 0.025). There was no significant correlation between the ganiclovir concentration in the tears and CCT (Spearmen's r = + 0.39, p = 0.11).RESULTSThere were 29 eyes of 29 patients, of which 23 eyes had CMV anterior uveitis and 6 eyes had CMV endotheliitis. At the end of week 6, 26 eyes had undetectable CMV titre in the aqueous humor and no anterior chamber (AC) activity. Two patients had an increased CMV titre and increased AC inflammation. Both of these patients were non-compliant with the treatment. One patient had a reduced CMV titre in the aqueous humor with minimal AC inflammation. The mean ganciclovir concentration in the aqueous humor and the tears were 17.4 ± 30.6 ng/ml and 20,420.9 ± 33,120.8 ng/ml respectively. Mean CCT was 552.2 ± 42.3 microns. There was a weak correlation between the ganciclovir concentration in the aqueous humor and CCT (Spearmen's r = + 0.42, p = 0.025). There was no significant correlation between the ganiclovir concentration in the tears and CCT (Spearmen's r = + 0.39, p = 0.11).Ganciclovir levels in the aqueous humor was below the 50% inhibitory dose (ID50) for CMV replication, following topical application of the ganciclovir gel, 0.15%.CONCLUSIONGanciclovir levels in the aqueous humor was below the 50% inhibitory dose (ID50) for CMV replication, following topical application of the ganciclovir gel, 0.15%.SingHealth Centralized Institutional Review Board, Singapore; R733/17/2010, ClinicalTrials.gov; NCT01647529.TRIAL REGISTRATIONSingHealth Centralized Institutional Review Board, Singapore; R733/17/2010, ClinicalTrials.gov; NCT01647529. Purpose To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection. Design Non-randomized, prospective, interventional clinical study. Methods Patients with active CMV anterior segment infection seen at Singapore National Eye Centre, confirmed by positive CMV real time PCR (RT-PCR) of the aqueous humor, that had not been treated with any form of ganciclovir in the preceding 1 month were recruited. They were treated with ganciclovir gel, 0.15% 1cc 5 times a day. Following 6 weeks of treatment, CMV load in the aqueous humor was measured using CMV RT-PCR and the ganciclovir drug levels in tears and aqueous humor were measured using high-performance liquid chromatography-mass spectrometry. The clinical features of the disease activity and the central corneal thickness (CCT) were recorded at the baseline and post-treatment. Results There were 29 eyes of 29 patients, of which 23 eyes had CMV anterior uveitis and 6 eyes had CMV endotheliitis. At the end of week 6, 26 eyes had undetectable CMV titre in the aqueous humor and no anterior chamber (AC) activity. Two patients had an increased CMV titre and increased AC inflammation. Both of these patients were non-compliant with the treatment. One patient had a reduced CMV titre in the aqueous humor with minimal AC inflammation. The mean ganciclovir concentration in the aqueous humor and the tears were 17.4 ± 30.6 ng/ml and 20,420.9 ± 33,120.8 ng/ml respectively. Mean CCT was 552.2 ± 42.3 microns. There was a weak correlation between the ganciclovir concentration in the aqueous humor and CCT (Spearmen's r = + 0.42, p = 0.025). There was no significant correlation between the ganiclovir concentration in the tears and CCT (Spearmen's r = + 0.39, p = 0.11). Conclusion Ganciclovir levels in the aqueous humor was below the 50% inhibitory dose (ID50) for CMV replication, following topical application of the ganciclovir gel, 0.15%. Trial registration SingHealth Centralized Institutional Review Board, Singapore; R733/17/2010, ClinicalTrials.gov; NCT01647529. |
| Author | Chee, Soon-Phaik Waduthantri, Samanthila Zhou, Lei |
| AuthorAffiliation | Hospital JP Garrahan, ARGENTINA 1 Singapore Eye Research Institute, Singapore, Singapore 4 Ophthalmology and Visual Sciences Academic Clinical Research Program, Duke-NUS Graduate Medical School, Singapore, Singapore 2 Singapore National Eye Centre, Singapore, Singapore 3 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore |
| AuthorAffiliation_xml | – name: 3 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore – name: 2 Singapore National Eye Centre, Singapore, Singapore – name: 1 Singapore Eye Research Institute, Singapore, Singapore – name: 4 Ophthalmology and Visual Sciences Academic Clinical Research Program, Duke-NUS Graduate Medical School, Singapore, Singapore – name: Hospital JP Garrahan, ARGENTINA |
| Author_xml | – sequence: 1 givenname: Samanthila orcidid: 0000-0001-8587-2411 surname: Waduthantri fullname: Waduthantri, Samanthila – sequence: 2 givenname: Lei surname: Zhou fullname: Zhou, Lei – sequence: 3 givenname: Soon-Phaik surname: Chee fullname: Chee, Soon-Phaik |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29377953$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UtuKFDEQbWTFvegfiAYWwQdnTDqdTmcfhGXxMrDgiz6HdLq6zZBO2iQ9sp_gX5u5ye4iPqWoOufUqUqdFyfOOyiKlwQvCeXk_drPwSm7nHJ6iYkgDcNPijMiaLmoS0xP7sWnxXmMa4wZber6WXFaCsq5YPSs-L1yKaiFViMEZZGFDVjkezQop422fmMCGsC-Q7kre4N6b63_ZdyAkp-Mzgw1TTYHyXiXqwHpu-RHGNSOOkekXIJgciHCMIJLyLge9BZ-ha7RZKxPKKa5u3tePO2VjfDi8F4U3z99_HbzZXH79fPq5vp2oZko06Lras5JjzHviKjakgIIXouacSgZrXHNGBAMfQWUUFFVfaUbVrZAeyHU9r0oXu91J-ujPGwxypIKXNMKN2VGrPaIzqu1nIIZVbiTXhm5S_gwSBVS3g7IigpVcQ6sbnDVsuxQsbalHNMSN7rRWevDodvcjtBp2K7bPhB9WHHmhxz8RjLeNHmcLPD2IBD8zxlikqOJGqxVDvwcJRGC4jxpzTP08hH039O9uu_or5XjTWTA1R6gg48xQC-1SbsPzgaNlQTL7QEexeX2AOXhADO5ekQ-6v-X9gduAuNH |
| CitedBy_id | crossref_primary_10_1590_s1678_9946202163084 crossref_primary_10_1186_s12886_021_02155_3 crossref_primary_10_1097_ICO_0000000000001847 crossref_primary_10_1016_j_jtos_2021_07_002 crossref_primary_10_4103_ijo_IJO_928_20 crossref_primary_10_1080_09273948_2024_2329315 crossref_primary_10_1186_s40662_020_00226_y crossref_primary_10_2147_OPTH_S376039 crossref_primary_10_1038_s41433_019_0497_9 crossref_primary_10_1080_09273948_2024_2345848 crossref_primary_10_1080_09273948_2024_2320704 crossref_primary_10_1007_s10384_019_00665_8 crossref_primary_10_2147_IDR_S370905 crossref_primary_10_3389_fpubh_2023_1117412 crossref_primary_10_1080_09273948_2020_1766083 crossref_primary_10_3390_v16071110 crossref_primary_10_1167_iovs_18_24750 crossref_primary_10_1016_j_survophthal_2021_12_006 crossref_primary_10_1111_ceo_14469 crossref_primary_10_1016_j_survophthal_2025_02_002 crossref_primary_10_1055_a_1425_4809 crossref_primary_10_3390_v15010185 crossref_primary_10_1080_09273948_2019_1662059 crossref_primary_10_4103_sjopt_sjopt_120_24 crossref_primary_10_1097_ICU_0000000000000521 crossref_primary_10_1007_s10384_024_01106_x crossref_primary_10_1007_s40135_019_00205_0 crossref_primary_10_1016_j_jconrel_2024_05_031 |
| ContentType | Journal Article |
| Copyright | 2018 Waduthantri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2018 Waduthantri et al 2018 Waduthantri et al |
| Copyright_xml | – notice: 2018 Waduthantri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2018 Waduthantri et al 2018 Waduthantri et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0191850 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection ProQuest Agricultural & Environmental Science Database ProQuest Central Essentials Biological Science Collection ProQuest Central (New) Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database Health & Medical Collection (Alumni) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Intra-cameral drug levels following topical application of ganciclovir gel |
| EISSN | 1932-6203 |
| ExternalDocumentID | 2390634082 oai_doaj_org_article_439a477e56804b5592a5bb3703208c8c PMC5788360 29377953 10_1371_journal_pone_0191850 |
| Genre | Clinical Trial Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | France Singapore |
| GeographicLocations_xml | – name: Singapore – name: France |
| GrantInformation_xml | – fundername: ; grantid: SNEC HREF R733/17/2010 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM CGR CUY CVF ECM EIF IPNFZ NPM PJZUB PPXIY PQGLB RIG 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 5PM PUEGO AAPBV ABPTK BBORY N95 |
| ID | FETCH-LOGICAL-c592t-dd6771f007d194b23ee9769657e25360655e10ef4e313944f4c852be3f99a2be3 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Sun Jun 04 06:37:02 EDT 2023 Wed Aug 27 01:22:03 EDT 2025 Thu Aug 21 18:18:38 EDT 2025 Fri Jul 11 01:27:57 EDT 2025 Fri Jul 25 11:24:55 EDT 2025 Tue Jul 29 01:37:20 EDT 2025 Tue Jul 01 01:16:17 EDT 2025 Thu Apr 24 23:07:57 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c592t-dd6771f007d194b23ee9769657e25360655e10ef4e313944f4c852be3f99a2be3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. |
| ORCID | 0000-0001-8587-2411 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0191850 |
| PMID | 29377953 |
| PQID | 2390634082 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_2390634082 doaj_primary_oai_doaj_org_article_439a477e56804b5592a5bb3703208c8c pubmedcentral_primary_oai_pubmedcentral_nih_gov_5788360 proquest_miscellaneous_1993013967 proquest_journals_2390634082 pubmed_primary_29377953 crossref_citationtrail_10_1371_journal_pone_0191850 crossref_primary_10_1371_journal_pone_0191850 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018-01-01 |
| PublicationDateYYYYMMDD | 2018-01-01 |
| PublicationDate_xml | – month: 01 year: 2018 text: 2018-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2018 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | ref12 N Castela (ref13) 1994; 10 HB Hoh (ref35) 1996; 80 O Singh (ref19) 2011; 44 ref11 ref33 SP Chee (ref2) 2007; 114 UB Kompella (ref14) 2010; 1 SP Chee (ref3) 2008; 145 B Daicker (ref30) 1988; 197 T Matthews (ref32) 1988; 10 SP Chee (ref6) 2010; 94 J Colin (ref36) 1997; 16 UG Kapanigowda (ref18) 2015; 23 RW Yee (ref25) 1991; 51 K Cholkar (ref15) 2013; 29 SP Chee (ref4) 2008; 146 B Sobolewska (ref8) 2014; 252 CC Su (ref10) 2013; 41 CS Foster (ref37) 2007; 3 DA Jabs (ref16) 2005; 140 M Miyanaga (ref23) 2010; 94 RN Van Gelder (ref1) 2008; 146 A Sahin (ref34) 2012; 4 A Anshu (ref5) 2009; 116 N Koizumi (ref9) 2015; 99 N Koizumi (ref29) 2017; 101 N Morlet (ref21) 1996; 80 N Koizumi (ref26) 2008; 115 GS Tirucherai (ref22) 2002; 18 LA Van Boxtel (ref7) 2007; 114 M Labetoulle (ref20) 2016; 100 A Carmichael (ref27) 2012; 26 KR Wilhelmus (ref24) 1996; 114 JD Bartlett (ref28) 2008 KF Tabbara (ref31) 2010; 4 BG Katzung (ref17) 2015 |
| References_xml | – volume: 44 start-page: 907 issue: 10–11 year: 2011 ident: ref19 article-title: Determination of valganciclovir and ganciclovir in human plasma by liquid chromatography tandem mass spectrometric detection – start-page: 20 year: 2008 ident: ref28 – volume: 10 start-page: 439 year: 1994 ident: ref13 article-title: Ganciclovir ophthalmic gel in herpes simplex virus rabbit keratitis: intraocular penetration and efficacy – volume: 80 start-page: 214 issue: 3 year: 1996 ident: ref21 article-title: High dose intravitreal ganciclovir injection provides a prolonged therapeutic intraocular concentration – volume: 26 start-page: 237 issue: 2 year: 2012 ident: ref27 article-title: Cytomegalovirus and the eye – volume: 51 start-page: 1040 issue: 5 year: 1991 ident: ref25 article-title: Apparent cytomegalovirus epithelial keratitis in a cardiac transplant recipient – volume: 197 start-page: 169 year: 1988 ident: ref30 article-title: Cytomegalovirus panuveitis with infection of corneo-trabecular endothelium in AIDS – volume: 114 start-page: 1358 year: 2007 ident: ref7 article-title: Cytomegalovirus as a cause of anterior uveitis in immunocompetent patients – volume: 41 start-page: 339 year: 2013 ident: ref10 article-title: Topical ganciclovir treatment in patients with cytomegalovirus endotheliitis receiving penetrating keratoplasty – volume: 114 start-page: 798 year: 2007 ident: ref2 article-title: Corneal endotheliitis associated with evidence of cytomegalovirus infection – volume: 1 start-page: 435 issue: 3 year: 2010 ident: ref14 article-title: Recent advances in ophthalmic drug delivery – volume: 16 start-page: 393 issue: 4 year: 1997 ident: ref36 article-title: Ganciclovir ophthalmic gel (Virgan; 0.15%) in the treatment of herpes simplex keratitis – volume: 115 start-page: 292 year: 2008 ident: ref26 article-title: CMV as an etiologic factor in corneal endotheliitis – volume: 146 start-page: 883 year: 2008 ident: ref4 article-title: Presumed Fuchs heterochromic iridocyclitis and Posner–Schlossman syndrome: comparison of cytomegalovirus positive and negative eyes – volume: 4 start-page: 23 year: 2012 ident: ref34 article-title: Acute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel? – ident: ref11 – volume: 94 start-page: 1648 issue: 12 year: 2010 ident: ref6 article-title: Cytomegalovirus anterior uveitis: outcome of treatment – volume: 23 start-page: 49 year: 2015 ident: ref18 article-title: Improved intraocular bioavailability of ganciclovir by mucoadhesive polymer based ocular microspheres: development and simulation process in Wistar rats – volume: 252 start-page: 117 issue: 1 year: 2014 ident: ref8 article-title: Long-term oral therapy with valganciclovir in patients with Posner-Schlossman syndrome – volume: 99 start-page: 54 issue: 1 year: 2015 ident: ref9 article-title: Japan Corneal Endotheliitis Study Group. Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study – volume: 146 start-page: 769 issue: 6 year: 2008 ident: ref1 article-title: Idiopathic No More: Clues to the Pathogenesis of Fuchs Heterochromic Iridocyclitis and Glaucomatocyclitic Crisis – volume: 10 start-page: S490 issue: Suppl 3 year: 1988 ident: ref32 article-title: Antiviral activity and mechanism of action of ganciclovir – volume: 116 start-page: 624 issue: 4 year: 2009 ident: ref5 article-title: Cytomegalovirus Endotheliitis in Descemet's Stripping Endothelial Keratoplasty – volume: 140 start-page: 509 year: 2005 ident: ref16 article-title: Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop – volume: 114 start-page: 869 issue: 7 year: 1996 ident: ref24 article-title: Cytomegalovirus keratitis in acquired immunodeficiency syndrome – volume: 80 start-page: 140 year: 1996 ident: ref35 article-title: Goldschmidt P atal. Randomized trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicenter study – volume: 101 start-page: 114 year: 2017 ident: ref29 article-title: The effect of topical application of 0.15% ganciclovir gel on cytomegalovirus corneal endotheliitis – volume: 94 start-page: 336 issue: 3 year: 2010 ident: ref23 article-title: A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis – volume: 18 start-page: 535 issue: 6 year: 2002 ident: ref22 article-title: Corneal Permeation of Ganciclovir: Mechanism of Ganciclovir Permeation Enhancement by Acyl Ester Prodrug Design – volume: 4 start-page: 905 year: 2010 ident: ref31 article-title: Topical ganciclovir in the treatment of acute herpetic keratitis – volume: 3 start-page: 52 year: 2007 ident: ref37 article-title: Ganciclovir Gel—A New Topical Treatment for Herpetic Keratitis – start-page: 1239 year: 2015 ident: ref17 article-title: Basic & Clinical Pharmacology – volume: 145 start-page: 834 year: 2008 ident: ref3 article-title: Clinical features of cytomegalovirus anterior uveitis in immunocompetent patients – volume: 29 start-page: 106 issue: 2 year: 2013 ident: ref15 article-title: Novel Strategies for Anterior Segment Ocular Drug Delivery – ident: ref12 – ident: ref33 – volume: 100 start-page: 976 issue: 7 year: 2016 ident: ref20 article-title: Evaluation of the efficacy and safety of a standardised intracameral combination of mydriatics and anaesthetics for cataract surgery |
| SSID | ssj0053866 |
| Score | 2.4095812 |
| Snippet | To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment... Purpose To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior... PurposeTo investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment... Purpose To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior... |
| SourceID | plos doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0191850 |
| SubjectTerms | Administration, Ophthalmic Adult Aged Aged, 80 and over Anterior chamber Anterior Eye Segment - pathology Antiviral Agents - administration & dosage Antiviral drugs Aqueous humour Biology and Life Sciences Chromatography Chromatography, Liquid Cornea Correlation Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus Infections - drug therapy Female Ganciclovir Ganciclovir - administration & dosage Health services Herpes viruses High performance liquid chromatography Humans Infections Laboratories Levels Liquid chromatography Male Mass spectrometry Mass spectroscopy Medicine and Health Sciences Middle Aged Patients Physical Sciences Pilot Projects Polymerase chain reaction Prospective Studies Real-Time Polymerase Chain Reaction Research and Analysis Methods Scientific imaging Tandem Mass Spectrometry Tears Topical application Transplants & implants Uveitis |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT1wQ5dVAQUYCCSTSJvEr4VYQVUGCE5V6i2xnsqyUJqtNFsRP4F8zkzirXVSpF06RMnYenrHnsz3-hrFXFn0iuvksdmmSxBIyiF1e1LFwwtSpdlU-7uB__aYvLuWXK3W1k-qLYsImeuCp4U7RYVppDCidJ9Ih_s2scvggSvyd-9zT6Is-b55MTWMw9mKtw0E5YdLToJeTVdfCCYIadFLJniMa-fqJ37Tp-puw5r8hkzs-6Pw-uxfAIz-bPvqQ3YH2ATsM3bPnbwKH9NuH7M9nekDs7bjmxBsKDeJdzRdEr-Gb7udyzRfQvOO06POa12gN3S_0YnzoVqQ2vrOxjdI197-H7hrQnVDVTc9HhSxR0MOCFhj5HNXVvudnfLVsuoGP1LWP2OX5p-8fL-KQdSH22LhDXFXamLRG7FClhXSZAEDIUmhlIFMC5ztKQZpALUGkdKq2lj5XmQNRF4Wl62N20GI7HzEOeVJr6TVqXUqb5i6pQFGiDyE9WFtETMwqKH2gJKfMGE057rMZnJpMDVuS4sqguIjF21qriZLjlvIfSLvbskSoPd5AMyuDmZW3mVnEjsg25hf0ZSYKRHeUrjtix7O93Cx-uRVj16X9GNtCt-lLip0kBK5NxJ5M5rX9SERhxhRKRMzsGd7eX-xL2uWPkR4cx2A6mfP0f_z2M3YXEWI-rTkds4NhvYHniMIG92LscH8B8D8xIw priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3db5RAEN9offHFWL-KVrMmmmjitsB-gS-mGptqok82uTfCLsv1EmTx4DT-Cf7XzsAe9kyjT5cwwAEzs_Obj50h5FkJNhHMfMpMEsdMuNQxk-U144brOlGmysYM_qfP6uxcfFzIRQi49aGscrsmjgt15S3GyI9TcM4Vx_HIb7pvDKdGYXY1jNC4Tm5g6zIs6dKL2eECXVYqbJfjOjkO3DnqfOuOANqAqYp3zNHYtR-7nDa-vwpx_l04eckSnd4mtwKEpCcTz_fJNdfeIftBSXv6InSSfnmX_PqAN2C2HCNPtMECIeprusQmG7bx31drunTNK4qhn-e0BpnwP8CW0cF3yDx6Kb0N1DW1Pwf_1YFRwUs3PR3ZsgJC75YYZqTb2q72NT2h3arxAx0b2N4j56fvv7w7Y2H2ArMyTwdWVUrrpAYEUSW5MCl3DoBLrqR2qeTg9UjpktjVwvEE99bWwmYyNY7XeV7i732y18J3PiDUZXGthFXAeyHKJDNx5SSO--DCurLMI8K3LChsaEyO8zGaYsy2aXBQpg9bIOOKwLiIsPmqbmrM8Z_z3yJ353OxrfZ4wK-XRdDSAtBZKbR2UmWxMOBspaU0ILU4ZT6zmY3IAcrG9g_64o9URuRwKy9Xk5_OZFBgzMqUrfObvsAKSsThSkfkwSRe80MCFtM6lzwiekfwdt5il9KuLsYm4bAS4_6ch_9-rEfkJiDAbIopHZK9Yb1xjwFlDebJqEq_AUTEKf4 priority: 102 providerName: ProQuest |
| Title | Intra-cameral level of ganciclovir gel, 0.15% following topical application for cytomegalovirus anterior segment infection: A pilot study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/29377953 https://www.proquest.com/docview/2390634082 https://www.proquest.com/docview/1993013967 https://pubmed.ncbi.nlm.nih.gov/PMC5788360 https://doaj.org/article/439a477e56804b5592a5bb3703208c8c http://dx.doi.org/10.1371/journal.pone.0191850 |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1ta9swEBZd-2Vfxrq3eu2CBhtsMAe_SJY8GKMtzbpByxgL5JuxZTkNeFZmO936E_avdyfboRkp--JAznIS3V3uuZP0HCGvUoiJEOYDN_M9z2U60G4m48INs1AUfpTl0q7gX1xG51P2ZcZnO2To2dpPYLM1tcN-UtO6HP_-efMRHP6D7dog_GHQeGkqPQbIAiEIkvg9iE0CXfWCrdcVwLujqD9Ad9dIpAeOkYaPhxuxylL6IwVqaZptcPTfXZW3wtTkIXnQ40t63BnEPtnR1SOy33twQ9_0NNNvH5M_n_EBrkptWYqWuHuImoLOkYFDleZ6UdO5Lt9RrAu9pgUYjPkFgY62ZomapbfWvkFaU3XTmh8aIg4OXTXU6mwBgkbPsQZJh41f1Xt6TJeL0rTUsts-IdPJ2ffTc7dvzOAqHgetm-eREH4B8CL3Y5YFodaAauKICx3wEFIizrXv6YLp0MeDtwVTkgeZDos4TvH1KdmtYMoPCNXSKyKmIjAMxlJfZl6uOfYCCZnSaRo7JBxUkKietRybZ5SJXYoTkL10E5ugDpNehw5x16OWHWvHf-4_Qe2u70XObfuGqedJ78IJQLeUCaF5JD2WQSYWpDwDk8YW9FJJ5ZADtI3hA5okCGMAgNjR2yFHg71sF79ci8G7cckmrbRZNQlur0SQHgmHPOvMa_0lByt1iNgwvI1fsSmpFleWQRz-pvHwzvM7n3lI7gMylF2t6YjstvVKvwD01WYjck_MBFzlqY_XyacR2Ts5u_z6bWTrGSPrcH8Byi007Q |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Zb9QwELZKeYAXRLkaKGAkKoFE2iSO7QQJoXJUu_R4aqV9S2PHWVYKcdhkqfoT-DP8RmZyLF1UwVOfIq1zbeabezxDyMsUdCKo-cBVvue5oQmMq6I4d5liMveFyqI2g390LEan4ZcJn6yRX8NeGCyrHGRiK6gzqzFGvhuAcy4Yjkd-X313cWoUZleHERodLA7MxTm4bPW78Seg73YQ7H8--Thy-6kCruZx0LhZJqT0c9CNGTjwKmDGgEqOBZcm4Azsec6N75k8NMzHXaN5qCMeKMPyOE7xCPe9QW6C4vWQo-Rk6eCB7BCi357HpL_bo2GnsqXZAVMKVKO3ov7aKQHYVbWw9VUW7t-Fmpc03_5dcqc3Weleh7ENsmbKe2SjFwo1fdV3rn59n_wc4w1cnbaRLlpgQRK1OZ1iUw9d2B-zOZ2a4g3FUNM2zQGD9hx0J21shWChl9LpsDqn-qKx3wwoMbx0UdMWBjNYqM0Uw5p0qCUr39I9Ws0K29C2Ye4DcnotVHlI1kv4zpuEmsjLRagFYC0MUz9SXmY4jhdhoTZpGjuEDSRIdN8IHedxFEmb3ZPgEHUfNkHCJT3hHOIur6q6RiD_Of8DUnd5Lrbxbn-w82nSS4UErME0lNJwEXmhAucuSLkCLsGp9pGOtEM2ERvDA-rkDxc4ZGvAy9XLL5bLIDAwC5SWxi7qBCs20e4X0iGPOngtXxJsPyljzhwiV4C38i9WV8rZ17YpOUh-3A_0-N-v9ZzcGp0cHSaH4-ODJ-Q2WJ9RF8_aIuvNfGGegoXXqGctW1Fydt18_BtWU2VV |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ba9RAFB5qBfFFrLdGq45gQcHpJpnMTCKIVOvStVp8sLBvMZlM1oWYiZuspT_Bv-Sv85xc1q4UfepTYCe3zfnO_cw5hDxNQCeCmvdZ6rkuC4xvWBpGOeMpV7kn0yxsM_gfj-XhSfB-KqYb5NewFwbLKgeZ2ArqzGqMkY98cM4lx_HIo7wvi_h0MH5dfWc4QQozrcM4jQ4iR-bsFNy3-tXkAGi96_vjd5_fHrJ-wgDTIvIblmVSKS8HPZmBM5_63BhQz5EUyviCg20vhPFckweGe7iDNA90KPzU8DyKEjzCfa-Qq4oLD3lMTVfOHsgRKfutelx5ox4Ze5UtzR6YVaAm3TVV2E4MwA6rha0vsnb_Lto8pwXHN8mN3nyl-x3etsiGKW-RrV5A1PRZ38X6-W3yc4I3YDppo160wOIkanM6wwYfurA_5gs6M8ULimGnXZoDHu0p6FHa2AqBQ8-l1mF1QfVZY78ZUGh46bKmLSTmsFCbGYY46VBXVr6k-7SaF7ahbfPcO-TkUqhyl2yW8J23CTWhm8tAS8BdECRemLqZEThqhAfaJEnkED6QINZ9U3SczVHEbaZPgXPUfdgYCRf3hHMIW11VdU1B_nP-G6Tu6lxs6d3-YBezuJcQMViGSaCUETJ0gxQcPT8RKXAMTrgPdagdso3YGB5Qx384wiE7A14uXn6yWgbhgRmhpDR2WcdYvYk-gFQOudfBa_WSYAcqFQnuELUGvLV_sb5Szr-2DcpBC-DeoPv_fq3H5BpwcPxhcnz0gFwHQzTsQls7ZLNZLM1DMPaa9FHLVZR8uWw2_g3izGmL |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Intra-cameral+level+of+ganciclovir+gel%2C+0.15%25+following+topical+application+for+cytomegalovirus+anterior+segment+infection%3A+A+pilot+study&rft.jtitle=PloS+one&rft.au=Waduthantri%2C+Samanthila&rft.au=Zhou%2C+Lei&rft.au=Chee%2C+Soon-Phaik&rft.date=2018-01-01&rft.eissn=1932-6203&rft.volume=13&rft.issue=1&rft.spage=e0191850&rft_id=info:doi/10.1371%2Fjournal.pone.0191850&rft_id=info%3Apmid%2F29377953&rft.externalDocID=29377953 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |