Discovery of a Viral NLR Homolog that Inhibits the Inflammasome

• Published in: Science (American Association for the Advancement of Science) Vol. 331; no. 6015; pp. 330 - 334
• Main Authors: Gregory, Sean M, Davis, Beckley K, West, John A, Taxman, Debra J, Matsuzawa, Shu-ichi, Reed, John C, Ting, Jenny P.Y, Damania, Blossom
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 21.01.2011; The American Association for the Advancement of Science
• Subjects: Activation; Adaptor Proteins, Signal Transducing - antagonists & inhibitors; Adaptor Proteins, Signal Transducing - chemistry; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Amino Acid Sequence; Apoptosis; Apoptosis Regulatory Proteins - antagonists & inhibitors; Apoptosis Regulatory Proteins - chemistry; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Binding; Biological and medical sciences; Blocking; Cancer; Carrier Proteins - metabolism; Caspase 1 - metabolism; Caspase Inhibitors; Cell death; Cell Line; Cell Line, Tumor; Cell lines; Cellular biology; Cellular immunity; Fundamental and applied biological sciences. Psychology; Grants; Herpes viruses; Herpesvirus 8, Human - genetics; Herpesvirus 8, Human - immunology; Herpesvirus 8, Human - physiology; Human; Human herpesvirus 8; Humans; Immune Evasion; Immune system; Immunity, Innate; Infections; Inflammasomes - antagonists & inhibitors; Inflammasomes - metabolism; Inhibition; Interleukin-1beta - metabolism; Kaposi's sarcoma-associated herpesvirus; Microbiology; Microorganisms; Modulation; Molecular Sequence Data; Monocytes; Monocytes - virology; NLR Family, Pyrin Domain-Containing 3 Protein; NLR Proteins; Nod2 Signaling Adaptor Protein - metabolism; Nucleotides; Pattern Recognition; Plasmids; Progeny; Protein Binding; Protein Interaction Domains and Motifs; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Small interfering RNA; Transfection; Vero cells; Viral infections; Viral Proteins - chemistry; Viral Proteins - genetics; Viral Proteins - metabolism; Virology; Virus Activation; Virus Latency; Virus Replication; Gammaherpesvirinae; Virus; Human herpesvirus 8; Inflammasome; Host virus relation; Herpesviridae

The NLR (nucleotide binding and oligomerization, leucine-rich repeat) family of proteins senses microbial infections and activates the inflammasome, a multiprotein complex that promotes microbial clearance. Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to several human malignancies....