Method development and validation for rapid identification of epigallocatechin gallate using ultra-high performance liquid chromatography

• Published in: PloS one Vol. 15; no. 1; p. e0227569
• Main Authors: U. V., Ramakrishna, R., Shyam Sunder, Kumar K., Rajesh, Narayan Sinha, Sukesh
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2020; Public Library of Science (PLoS)
• Subjects: Analytical methods; Biology and Life Sciences; Catechin; Catechin - analogs & derivatives; Catechin - analysis; Chromatography; Chromatography, High Pressure Liquid - methods; Correlation coefficient; Correlation coefficients; Engineering and Technology; Epigallocatechin gallate; Epigallocatechin-3-gallate; High performance liquid chromatography; Ions; Limit of Detection; Linearity; Liquid chromatography; Mathematical analysis; Medicine and Health Sciences; Nutrition; Optimization; Oxidation; Physical Sciences; Research and Analysis Methods; Robustness; Ruggedness; Software; Tea; Toxicity; United States > US; India

Although Epigallocatechin gallate (EGCG) is the most available and beneficial catechin found in tea, its auto-oxidation property may lead to toxicity when consumed in large quantities. Thus, there is a need to quantify the EGCG, which enables to study the pharmacological characteristics of the compo...