Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells

• Published in: Journal of controlled release Vol. 105; no. 3; pp. 269 - 278
• Main Authors: Minko, Tamara, Batrakova, Elena V., Li, Shu, Li, Yili, Pakunlu, Refika I., Alakhov, Valery Yu, Kabanov, Alexander V.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 20.07.2005; Elsevier
• Subjects: Annexin A5 - pharmacology; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Biological and medical sciences; Breast Neoplasms - metabolism; Cell Line, Tumor; Doxorubicin - pharmacology; Drug Resistance, Neoplasm; Enzyme Inhibitors - pharmacology; Epithelial Cells - metabolism; Excipients - pharmacology; Female; Gene Expression Regulation - drug effects; General pharmacology; Genes, MDR; Humans; In Situ Nick-End Labeling; KB Cells; Medical sciences; Microscopy, Confocal; Microscopy, Fluorescence; Multidrug resistance; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Pluronic; Poloxamer - pharmacology; Polymer; Signal Transduction - drug effects; Solutions; Polymer; Pluronic; Multidrug resistance; Apoptosis; Antineoplastic agent; Drug; DNA topoisomerase (ATP-hydrolysing); Pharmaceutical technology; Enzyme; Control release polymer; Vehicle(excipient); Enzyme inhibitor; Laxative; Doxorubicin; Signal transduction; Antibiotic; Isomerases; Cell death; Multiple resistance; Poloxamer; Anthracyclins; Tumor cell; Block copolymer

Pluronic block copolymer P85 (P85) sensitizes multidrug resistant (MDR) cancer cells resulting in the increase of cytotoxic activity of antineoplastic agents. This effect is attributed to the inhibition of the most clinically relevant drug efflux transporter, P-glycoprotein (Pgp), through the combin...