Profiling Chromatin Accessibility at Single-cell Resolution

• Published in: Genomics, proteomics & bioinformatics Vol. 19; no. 2; pp. 172 - 190
• Main Authors: Sinha, Sarthak, Satpathy, Ansuman T., Zhou, Weiqiang, Ji, Hongkai, Stratton, Jo A., Jaffer, Arzina, Bahlis, Nizar, Morrissy, Sorana, Biernaskie, Jeff A.
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.04.2021; Hotchkiss Brain Institute,University of Calgary,Calgary,AB T2N 4N1,Canada%Arnie Charbonneau Cancer Institute,University of Calgary,Calgary,AB T2N 4Z6,Canada%Alberta Children's Hospital Research Institute,University of Calgary,Calgary,AB T2N 4N1,Canada; Alberta Children's Hospital Research Institute,University of Calgary,Calgary,AB T2N 4N1,Canada; Department of Comparative Biology & Experimental Medicine,Faculty of Veterinary Medicine,University of Calgary,Calgary,AB T2N 4N1,Canada%Department of Pathology,Stanford University School of Medicine,Stanford,CA 94305,USA%Department of Biostatistics,Bloomberg School of Public Health,Johns Hopkins University,Baltimore,MD 21205,USA%Department of Comparative Biology & Experimental Medicine,Faculty of Veterinary Medicine,University of Calgary,Calgary,AB T2N 4N1,Canada; Arnie Charbonneau Cancer Institute,University of Calgary,Calgary,AB T2N 4Z6,Canada; Department of Biochemistry and Molecular Biology,Cumming School of Medicine,University of Calgary,Calgary,AB T2N 4N1,Canada; Elsevier; Oxford University Press
• Subjects: bioinformatics; chromatin; Chromatin - genetics; Cis-regulatory elements; Computational Biology; data collection; Epigenetics; epigenome; Gene regulation; genes; Genome; genomics; homeostasis; proteome; proteomics; Review; Single-Cell Analysis; Single-cell ATAC-seq; Single-cell multi-omics; transcription (genetics); Transcriptome; transcriptomics; Transposases - chemistry; Transposases - genetics; Transposases - metabolism; Single-cell ATAC-seq; Epigenetics; Single-cell multi-omics; Cis-regulatory elements; Gene regulation

How distinct transcriptional programs are enacted to generate cellular heterogeneity and plasticity, and enable complex fate decisions are important open questions. One key regulator is the cell’s epigenome state that drives distinct transcriptional programs by regulating chromatin accessibility. Ge...