Effect of Eicosapentaenoic Acid on E-type Prostaglandin Synthesis and EP4 Receptor Signaling Human Colorectal Cancer Cells

• Published in: Neoplasia (New York, N.Y.) Vol. 12; no. 8; pp. 618,IN1 - 627,IN2
• Main Authors: Hawcroft, Gillian, Loadman, Paul M., Belluzzi, Andrea, Hull, Mark A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2010; Neoplasia Press Inc; Elsevier
• Subjects: Adenoma - metabolism; Adenoma - pathology; Alprostadil - analogs & derivatives; Alprostadil - metabolism; Alprostadil - pharmacology; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Cell Proliferation - drug effects; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Culture Media - pharmacology; Dose-Response Relationship, Drug; Eicosapentaenoic Acid - pharmacology; Fatty Acids, Nonesterified - pharmacology; HT29 Cells; Humans; Prostaglandins E - antagonists & inhibitors; Prostaglandins E - biosynthesis; Protein Binding - drug effects; Receptors, Prostaglandin E, EP4 Subtype - agonists; Receptors, Prostaglandin E, EP4 Subtype - genetics; Receptors, Prostaglandin E, EP4 Subtype - metabolism; Signal Transduction - drug effects; Tumor Cells, Cultured; AA; FFA; RCT; FAP; CRC; TTBS; EPA; PG; COX

The ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA), in the free fatty acid (FFA) form, has been demonstrated to reduce adenoma number and size in patients with familial adenomatous polyposis. However, the mechanistic basis of the antineoplastic activity of EPA in the colorectum remains u...