Genome-wide DNA Methylation Changes in a Mouse Model of Infection-Mediated Neurodevelopmental Disorders

• Published in: Biological psychiatry (1969) Vol. 81; no. 3; pp. 265 - 276
• Main Authors: Richetto, Juliet, Massart, Renaud, Weber-Stadlbauer, Ulrike, Szyf, Moshe, Riva, Marco A., Meyer, Urs
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2017
• Subjects: Animals; Autism; Behavior, Animal - physiology; CpG Islands; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Epigenetics; Female; GABAergic Neurons - metabolism; Genome; Interpersonal Relations; Male; Maternal immune activation; Maze Learning - drug effects; Maze Learning - physiology; Mice; Mice, Inbred C57BL; Neurodevelopmental Disorders - chemically induced; Neurodevelopmental Disorders - genetics; Neurodevelopmental Disorders - immunology; Neurodevelopmental Disorders - metabolism; Poly I-C; Prefrontal Cortex - metabolism; Pregnancy; Prenatal Exposure Delayed Effects - genetics; Prenatal Exposure Delayed Effects - immunology; Prenatal Exposure Delayed Effects - metabolism; Prepulse Inhibition - drug effects; Prepulse Inhibition - physiology; Psychiatric/Mental Health; Schizophrenia; Wnt Signaling Pathway; DNA methylation; Epigenetics; Schizophrenia; Autism; Maternal immune activation; Poly(I:C)

Prenatal exposure to infectious or inflammatory insults increases the risk of neurodevelopmental disorders. Using a well-established mouse model of prenatal viral-like immune activation, we examined whether this pathological association involves genome-wide DNA methylation differences at single nucl...