Structural Hippocampal Damage Following Anti-N-Methyl-D-Aspartate Receptor Encephalitis

• Published in: Biological psychiatry (1969) Vol. 79; no. 9; pp. 727 - 734
• Main Authors: Finke, Carsten, Kopp, Ute A., Pajkert, Anna, Behrens, Janina R., Leypoldt, Frank, Wuerfel, Jens T., Ploner, Christoph J., Prüss, Harald, Paul, Friedemann
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2016
• Subjects: Adolescent; Adult; Aged; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnostic imaging; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - pathology; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - psychology; Autoimmune encephalitis; Diffusion Tensor Imaging; Female; Hippocampus; Hippocampus - diagnostic imaging; Hippocampus - pathology; Humans; Magnetic Resonance Imaging; Male; Memory; Middle Aged; MRI; NMDA; NMDA receptor; Psychiatric/Mental Health; Severity of Illness Index; Spatial Memory; Young Adult; NMDA; NMDA receptor; MRI; Memory; Hippocampus; Autoimmune encephalitis

The majority of patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis suffer from persistent memory impairment despite unremarkable routine clinical magnetic resonance imaging. With improved acute care in these patients, neurocognitive impairment represents the major contributor to l...