Sequence diversity and associated pathogenicity of the hemagglutinin cleavage site of H5N2 avian influenza viruses isolated from chickens in Taiwan during 2013–2015

• Published in: Journal of Veterinary Medical Science Vol. 79; no. 1; pp. 108 - 114
• Main Authors: LI, Kuang-Po, CHANG, Poa-Chun, CHENG, Ming-Chu, TAN, Duen-Huey, CHEN, Li-Hsuan, LIU, Yu-Pin, LIN, Yu-Ju, TSAI, Hsiang-Jung, SHIEN, Jui-Hung
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2017; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; Avian flu; avian influenza virus; Base Sequence; Chickens; Eggs; H5N2; hemagglutinin cleavage site; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; Hemagglutinins; Influenza; Influenza A Virus, H5N2 Subtype - genetics; Influenza A Virus, H5N2 Subtype - pathogenicity; Influenza in Birds - virology; Pandemics; Pathogenicity; RNA, Viral - genetics; Taiwan; Taiwan - epidemiology; Virology; Virulence; Taiwan

The sequence at the hemagglutinin (HA) cleavage site (CS) plays a key role in determining the pathogenicity of avian influenza viruses. Three types of HA CS sequences, QREKR/GL, QRKKR/GL and QRRKR/GL, were previously reported in Taiwanese H5N2 viruses that were isolated from chickens from 2003 to 20...