Cholangiocyte pathobiology

• Published in: Nature reviews. Gastroenterology & hepatology Vol. 16; no. 5; pp. 269 - 281
• Main Authors: Banales, Jesus M., Huebert, Robert C., Karlsen, Tom, Strazzabosco, Mario, LaRusso, Nicholas F., Gores, Gregory J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2019; Nature Publishing Group
• Subjects: 631/80; 692/4020/2741/44; 692/4020/4021/1328; Adaptive Immunity; Bile; Bile Duct Diseases - complications; Bile Duct Diseases - immunology; Bile Duct Diseases - pathology; Bile Duct Diseases - physiopathology; Bile ducts; Bile Ducts - pathology; Bile Ducts - physiology; Bile Ducts - physiopathology; Biliary tract; Biomedicine; Carcinogenesis; Cell development (Biology); Cell fate; Chemokines; Collagen; Common bile duct; Cytokines; Disease susceptibility; Epithelial cells; Epithelial Cells - immunology; Epithelial Cells - pathology; Epithelial Cells - physiology; Fibrosis; Gastroenterology; Health aspects; Hepatology; Homeostasis; Humans; Immune response; Immune system; Immunity, Innate; Immunoglobulin A; Inflammation; Liver; Liver diseases; Liver Failure - etiology; Liver Failure - physiopathology; Liver Regeneration; Medicine; Medicine & Public Health; Phenotypes; Physiological aspects; Regeneration; Review Article; Senescence; Toll-like receptors; Spain

Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are highly specialized cells residing in a complex anatomic niche where they participate in bile production and homeostasis. Cholangiocytes are damaged in a variety of human diseases termed cholangiopathies, of...