Dilution and titration of cell-cycle regulators may control cell size in budding yeast

• Published in: PLoS computational biology Vol. 14; no. 10; p. e1006548
• Main Authors: Heldt, Frank S., Lunstone, Reece, Tyson, John J., Novák, Béla
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2018; Public Library of Science (PLoS)
• Subjects: Applied mathematics; Binding sites; Biochemistry; Biology; Biology and Life Sciences; Cell cycle; Cell division; Cell growth; Cell size; Cell survival; Control theory; Copy number; Cyclin-dependent kinases; Deoxyribonucleic acid; Dilution; DNA; Feedback loops; Fitness; Gene expression; Homeostasis; Inhibitors; Kinases; Mathematical models; Mutants; Phosphorylation; Ploidy; Positive feedback; Proteins; Regulators; Research and Analysis Methods; Titration; Transcription factors; Yeast; United Kingdom > UK; United States > US; Virginia

The size of a cell sets the scale for all biochemical processes within it, thereby affecting cellular fitness and survival. Hence, cell size needs to be kept within certain limits and relatively constant over multiple generations. However, how cells measure their size and use this information to reg...