Targeting of CD44 eradicates human acute myeloid leukemic stem cells

• Published in: Nature medicine Vol. 12; no. 10; pp. 1167 - 1174
• Main Authors: Dick, John E, Jin, Liqing, Hope, Kristin J, Zhai, Qiongli, Smadja-Joffe, Florence
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.10.2006
• Subjects: Adhesion; ADP-ribosyl Cyclase 1 - biosynthesis; Animals; Antibodies, Monoclonal - chemistry; Antigens, CD34 - biosynthesis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Humans; Hyaluronan Receptors - biosynthesis; Immunotherapy; Immunotherapy - methods; Leukemia; Leukemia, Myeloid, Acute - metabolism; Leukemia, Myeloid, Acute - pathology; Leukemia, Myeloid, Acute - therapy; Mice; Mice, Inbred NOD; Mice, SCID; Monoclonal antibodies; Repopulation; Rodents; Stem cells; Stem Cells - cytology; Survival

The long-term survival of patients with acute myeloid leukemia (AML) is dismally poor. A permanent cure of AML requires elimination of leukemic stem cells (LSCs), the only cell type capable of initiating and maintaining the leukemic clonal hierarchy. We report a therapeutic approach using an activat...