A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study

Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. The association of this polymorphism with cardiac structure, function, and ischemia has...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 5; no. 10; p. e13496
Main Authors Farzaneh-Far, Ramin, Desir, Gary V., Schiller, Nelson B., Whooley, Mary A.
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 20.10.2010
Public Library of Science (PLoS)
Subjects
Adenine
Aged
Amino acids
Angina pectoris
Aspartic Acid - chemistry
Authorship
Beta blockers
Cardiomegaly - genetics
Cardiovascular disease
Cardiovascular Disorders
Catecholamines
Clinical trials
Coronary artery
Coronary artery disease
Coronary heart disease
Coronary vessels
Deoxyribonucleic acid
DNA
Echocardiography
Enzymatic activity
Enzymes
Female
Flavin-adenine dinucleotide
Gene polymorphism
Genetic aspects
Genetic testing
Genetics and Genomics
Genotypes
Glutamic Acid - chemistry
Health risk assessment
Heart
Heart attacks
Heart diseases
Heart failure
Heart hypertrophy
Hemodialysis
Human subjects
Humans
Hypertrophy
Ischemia
Kidney diseases
Male
Medicine
Middle Aged
Monoamine Oxidase - chemistry
Monoamine Oxidase - genetics
Mortality
Myocardial Ischemia - genetics
NADH
Nephrology
Nervous system
Nicotinamide adenine dinucleotide
Patients
Polymorphism
Polymorphism, Single Nucleotide
Prospective Studies
Purines
Quality of life
R&D
Research & development
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Structure-function relationships
Ventricle
United States > US
San Francisco Bay
California
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0013496

Cover

Abstract Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. The association of this polymorphism with cardiac structure, function, and ischemia has not previously been reported. We genotyped the rs2296545 single-nucleotide polymorphism (Glu37Asp) in 590 Caucasian individuals and performed resting and stress echocardiography. Logistic regression was used to examine the associations of the Glu37Asp polymorphism (C allele) with cardiac hypertrophy (LV mass>100 g/m2), systolic dysfunction (LVEF<50%), diastolic dysfunction, poor treadmill exercise capacity (METS<5) and inducible ischemia. Compared with the 406 participants who had GG or CG genotypes, the 184 participants with the CC genotype had increased odds of left ventricular hypertrophy (OR = 1.43; 95% CI 0.99-2.06), systolic dysfunction (OR = 1.72; 95% CI 1.01-2.94), diastolic dysfunction (OR = 1.75; 95% CI 1.05-2.93), poor exercise capacity (OR = 1.61; 95% CI 1.05-2.47), and inducible ischemia (OR = 1.49, 95% CI 0.99-2.24). The Glu37Asp (CC genotype) caused a 24-fold decrease in affinity for NADH and a 2.3-fold reduction in maximal renalase enzymatic activity. A functional missense polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, ventricular dysfunction, poor exercise capacity, and inducible ischemia in persons with stable coronary artery disease. Further studies investigating the therapeutic implications of this polymorphism should be considered.
AbstractList Background Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. The association of this polymorphism with cardiac structure, function, and ischemia has not previously been reported. Methods We genotyped the rs2296545 single-nucleotide polymorphism (Glu37Asp) in 590 Caucasian individuals and performed resting and stress echocardiography. Logistic regression was used to examine the associations of the Glu37Asp polymorphism (C allele) with cardiac hypertrophy (LV mass>100 g/m2), systolic dysfunction (LVEF<50%), diastolic dysfunction, poor treadmill exercise capacity (METS<5) and inducible ischemia. Results Compared with the 406 participants who had GG or CG genotypes, the 184 participants with the CC genotype had increased odds of left ventricular hypertrophy (OR = 1.43; 95% CI 0.99-2.06), systolic dysfunction (OR = 1.72; 95% CI 1.01-2.94), diastolic dysfunction (OR = 1.75; 95% CI 1.05-2.93), poor exercise capacity (OR = 1.61; 95% CI 1.05-2.47), and inducible ischemia (OR = 1.49, 95% CI 0.99-2.24). The Glu37Asp (CC genotype) caused a 24-fold decrease in affinity for NADH and a 2.3-fold reduction in maximal renalase enzymatic activity. Conclusions A functional missense polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, ventricular dysfunction, poor exercise capacity, and inducible ischemia in persons with stable coronary artery disease. Further studies investigating the therapeutic implications of this polymorphism should be considered.
Background Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. The association of this polymorphism with cardiac structure, function, and ischemia has not previously been reported. Methods We genotyped the rs2296545 single-nucleotide polymorphism (Glu37Asp) in 590 Caucasian individuals and performed resting and stress echocardiography. Logistic regression was used to examine the associations of the Glu37Asp polymorphism (C allele) with cardiac hypertrophy (LV mass>100 g/m2), systolic dysfunction (LVEF<50%), diastolic dysfunction, poor treadmill exercise capacity (METS<5) and inducible ischemia. Results Compared with the 406 participants who had GG or CG genotypes, the 184 participants with the CC genotype had increased odds of left ventricular hypertrophy (OR = 1.43; 95% CI 0.99–2.06), systolic dysfunction (OR = 1.72; 95% CI 1.01–2.94), diastolic dysfunction (OR = 1.75; 95% CI 1.05–2.93), poor exercise capacity (OR = 1.61; 95% CI 1.05–2.47), and inducible ischemia (OR = 1.49, 95% CI 0.99–2.24). The Glu37Asp (CC genotype) caused a 24-fold decrease in affinity for NADH and a 2.3-fold reduction in maximal renalase enzymatic activity. Conclusions A functional missense polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, ventricular dysfunction, poor exercise capacity, and inducible ischemia in persons with stable coronary artery disease. Further studies investigating the therapeutic implications of this polymorphism should be considered.
Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. The association of this polymorphism with cardiac structure, function, and ischemia has not previously been reported. We genotyped the rs2296545 single-nucleotide polymorphism (Glu37Asp) in 590 Caucasian individuals and performed resting and stress echocardiography. Logistic regression was used to examine the associations of the Glu37Asp polymorphism (C allele) with cardiac hypertrophy (LV mass>100 g/m2), systolic dysfunction (LVEF<50%), diastolic dysfunction, poor treadmill exercise capacity (METS<5) and inducible ischemia. Compared with the 406 participants who had GG or CG genotypes, the 184 participants with the CC genotype had increased odds of left ventricular hypertrophy (OR = 1.43; 95% CI 0.99-2.06), systolic dysfunction (OR = 1.72; 95% CI 1.01-2.94), diastolic dysfunction (OR = 1.75; 95% CI 1.05-2.93), poor exercise capacity (OR = 1.61; 95% CI 1.05-2.47), and inducible ischemia (OR = 1.49, 95% CI 0.99-2.24). The Glu37Asp (CC genotype) caused a 24-fold decrease in affinity for NADH and a 2.3-fold reduction in maximal renalase enzymatic activity. A functional missense polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, ventricular dysfunction, poor exercise capacity, and inducible ischemia in persons with stable coronary artery disease. Further studies investigating the therapeutic implications of this polymorphism should be considered.
Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. The association of this polymorphism with cardiac structure, function, and ischemia has not previously been reported. We genotyped the rs2296545 single-nucleotide polymorphism (Glu37Asp) in 590 Caucasian individuals and performed resting and stress echocardiography. Logistic regression was used to examine the associations of the Glu37Asp polymorphism (C allele) with cardiac hypertrophy (LV mass>100 g/m2), systolic dysfunction (LVEF<50%), diastolic dysfunction, poor treadmill exercise capacity (METS<5) and inducible ischemia. Compared with the 406 participants who had GG or CG genotypes, the 184 participants with the CC genotype had increased odds of left ventricular hypertrophy (OR = 1.43; 95% CI 0.99-2.06), systolic dysfunction (OR = 1.72; 95% CI 1.01-2.94), diastolic dysfunction (OR = 1.75; 95% CI 1.05-2.93), poor exercise capacity (OR = 1.61; 95% CI 1.05-2.47), and inducible ischemia (OR = 1.49, 95% CI 0.99-2.24). The Glu37Asp (CC genotype) caused a 24-fold decrease in affinity for NADH and a 2.3-fold reduction in maximal renalase enzymatic activity. A functional missense polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, ventricular dysfunction, poor exercise capacity, and inducible ischemia in persons with stable coronary artery disease. Further studies investigating the therapeutic implications of this polymorphism should be considered.
Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. The association of this polymorphism with cardiac structure, function, and ischemia has not previously been reported.BACKGROUNDRenalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. The association of this polymorphism with cardiac structure, function, and ischemia has not previously been reported.We genotyped the rs2296545 single-nucleotide polymorphism (Glu37Asp) in 590 Caucasian individuals and performed resting and stress echocardiography. Logistic regression was used to examine the associations of the Glu37Asp polymorphism (C allele) with cardiac hypertrophy (LV mass>100 g/m2), systolic dysfunction (LVEF<50%), diastolic dysfunction, poor treadmill exercise capacity (METS<5) and inducible ischemia.METHODSWe genotyped the rs2296545 single-nucleotide polymorphism (Glu37Asp) in 590 Caucasian individuals and performed resting and stress echocardiography. Logistic regression was used to examine the associations of the Glu37Asp polymorphism (C allele) with cardiac hypertrophy (LV mass>100 g/m2), systolic dysfunction (LVEF<50%), diastolic dysfunction, poor treadmill exercise capacity (METS<5) and inducible ischemia.Compared with the 406 participants who had GG or CG genotypes, the 184 participants with the CC genotype had increased odds of left ventricular hypertrophy (OR = 1.43; 95% CI 0.99-2.06), systolic dysfunction (OR = 1.72; 95% CI 1.01-2.94), diastolic dysfunction (OR = 1.75; 95% CI 1.05-2.93), poor exercise capacity (OR = 1.61; 95% CI 1.05-2.47), and inducible ischemia (OR = 1.49, 95% CI 0.99-2.24). The Glu37Asp (CC genotype) caused a 24-fold decrease in affinity for NADH and a 2.3-fold reduction in maximal renalase enzymatic activity.RESULTSCompared with the 406 participants who had GG or CG genotypes, the 184 participants with the CC genotype had increased odds of left ventricular hypertrophy (OR = 1.43; 95% CI 0.99-2.06), systolic dysfunction (OR = 1.72; 95% CI 1.01-2.94), diastolic dysfunction (OR = 1.75; 95% CI 1.05-2.93), poor exercise capacity (OR = 1.61; 95% CI 1.05-2.47), and inducible ischemia (OR = 1.49, 95% CI 0.99-2.24). The Glu37Asp (CC genotype) caused a 24-fold decrease in affinity for NADH and a 2.3-fold reduction in maximal renalase enzymatic activity.A functional missense polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, ventricular dysfunction, poor exercise capacity, and inducible ischemia in persons with stable coronary artery disease. Further studies investigating the therapeutic implications of this polymorphism should be considered.CONCLUSIONSA functional missense polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, ventricular dysfunction, poor exercise capacity, and inducible ischemia in persons with stable coronary artery disease. Further studies investigating the therapeutic implications of this polymorphism should be considered.
Audience Academic
Author Whooley, Mary A.
Desir, Gary V.
Schiller, Nelson B.
Farzaneh-Far, Ramin
AuthorAffiliation 4 Veterans Affairs Medical Center, San Francisco, California, United States of America
5 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
Maastricht University, Netherlands
1 Division of Cardiology, San Francisco General Hospital, San Francisco, California, United States of America
2 Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
3 Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America
AuthorAffiliation_xml – name: 4 Veterans Affairs Medical Center, San Francisco, California, United States of America
– name: Maastricht University, Netherlands
– name: 1 Division of Cardiology, San Francisco General Hospital, San Francisco, California, United States of America
– name: 2 Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
– name: 3 Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America
– name: 5 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
Author_xml – sequence: 1
  givenname: Ramin
  surname: Farzaneh-Far
  fullname: Farzaneh-Far, Ramin
– sequence: 2
  givenname: Gary V.
  surname: Desir
  fullname: Desir, Gary V.
– sequence: 4
  givenname: Nelson B.
  surname: Schiller
  fullname: Schiller, Nelson B.
– sequence: 5
  givenname: Mary A.
  surname: Whooley
  fullname: Whooley, Mary A.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20975995$$D View this record in MEDLINE/PubMed
BookMark eNp9kl1v0zAUhiM0xD7gHyCwxAUgrcUfSRzvAqnq2FppEojBtXXqOI2nJM7sBJQ_wu_FbVO0ThOKlFgn7_ucc5L3NDpqbKOj6DXBU8I4-XRne9dANW1DeYoxYbFIn0UnRDA6SSlmRw_Ox9Gp93cYJyxL0xfRMcWCJ0IkJ9GfGbrqG9UZG1jom62G2rq2NL5GpkHfdaiC1-jDddUzPvPtR7T0aOa9VQY6naPfpivRHFxuQKHF0GrXOduWwzm6HHwxks8RNHkwqlLXBi7QJXSACmdr1JUaLTS4bqu4tX2Fbrs-H15GzwuovH41Ps-in1dffswXk5uv18v57GaiEkG7iSgKkhKiYLVSPMOxgphCVqhMkKxIMMEiTRNFWbglQHPKNWYKSJrxmIFOGDuL3u64bWW9HD-pl4QKyjBNCA-K5U6RW7iTrTM1uEFaMHJbsG4tw_hGVVpqSpleJaTQjMciy7M89GWCr0SMieA0sD6P3fpVrXOlm85BdQA9fNOYUq7tL0lFkpHtMO9HgLP3vfadrI1Xuqqg0bb3kqeYEky2rd49Uj693KhaQ5jfNIUNbdWGKWcxZ1nMUpIG1fQJVbjy8DtViF9hQv3A8Obhnv8W3McuCC52AuWs904XUpkONlEJZFNJguUm4_uZ5Sbjcsx4MMePzHv-f21_AbT9AZY
CitedBy_id crossref_primary_10_1097_HJH_0b013e32834f0bb7
crossref_primary_10_1093_ndt_gft083
crossref_primary_10_1016_j_jmb_2011_06_010
crossref_primary_10_1007_s00467_014_2855_y
crossref_primary_10_1007_s00467_011_1828_7
crossref_primary_10_1016_j_ekir_2019_12_002
crossref_primary_10_1088_1742_6596_1853_1_012054
crossref_primary_10_1152_ajprenal_00196_2013
crossref_primary_10_1007_s12010_014_1433_x
crossref_primary_10_3109_03602532_2015_1102932
crossref_primary_10_1021_acs_biochem_5b00451
crossref_primary_10_1371_journal_pone_0179218
crossref_primary_10_1681_ASN_2013060665
crossref_primary_10_17650_1818_8338_2021_15_1_4_K644
crossref_primary_10_1097_MNH_0000000000000044
crossref_primary_10_1016_j_jash_2012_09_002
crossref_primary_10_3390_ijms18050855
crossref_primary_10_3390_cells12121607
crossref_primary_10_1007_s10157_014_0951_8
crossref_primary_10_1038_s41440_024_01931_0
crossref_primary_10_1111_1440_1681_13594
crossref_primary_10_1016_j_bbapap_2015_04_010
crossref_primary_10_1158_0008_5472_CAN_15_1524
crossref_primary_10_3389_fcvm_2022_845878
crossref_primary_10_1007_s00246_018_1891_y
crossref_primary_10_1152_ajprenal_00274_2014
crossref_primary_10_1042_BSR20180839
crossref_primary_10_1111_jcmm_12813
crossref_primary_10_1021_bi500798n
crossref_primary_10_1371_journal_pone_0186729
crossref_primary_10_3109_0886022X_2013_876352
crossref_primary_10_1093_ndt_gfr293
crossref_primary_10_1159_000355777
crossref_primary_10_7759_cureus_47903
crossref_primary_10_1111_jcmm_13062
crossref_primary_10_1080_03007995_2020_1756233
crossref_primary_10_3109_0886022X_2012_681534
crossref_primary_10_12659_MSM_890261
crossref_primary_10_1038_srep22996
crossref_primary_10_1161_JAHA_112_002634
crossref_primary_10_1097_HJH_0b013e32835d6e34
crossref_primary_10_1159_000439117
crossref_primary_10_1007_s11255_016_1270_7
crossref_primary_10_3109_0886022X_2013_778754
crossref_primary_10_1097_MNH_0b013e3283412721
crossref_primary_10_1016_j_transproceed_2014_09_033
crossref_primary_10_1016_j_ejmhg_2018_02_004
crossref_primary_10_1016_j_lfs_2023_121859
crossref_primary_10_4236_ojneph_2012_24021
crossref_primary_10_1016_j_biopha_2020_110712
crossref_primary_10_1159_000350157
crossref_primary_10_1177_1074248412446977
crossref_primary_10_1002_jcb_27595
crossref_primary_10_1159_000355802
crossref_primary_10_1007_s11255_015_1008_y
crossref_primary_10_1016_j_jmb_2015_07_003
crossref_primary_10_1016_j_jash_2014_04_009
crossref_primary_10_1016_j_abb_2015_05_016
crossref_primary_10_1016_j_transproceed_2011_08_075
crossref_primary_10_1038_s41440_022_00986_1
crossref_primary_10_1007_s10549_012_2322_z
crossref_primary_10_1155_2019_7265160
crossref_primary_10_3390_cells10082006
crossref_primary_10_1177_20406223241286677
crossref_primary_10_1016_j_abb_2017_05_015
crossref_primary_10_1016_j_advms_2014_10_001
crossref_primary_10_1177_0003319712459212
crossref_primary_10_1186_1471_2350_13_57
crossref_primary_10_1371_journal_pone_0122932
crossref_primary_10_1038_s41440_024_01850_0
crossref_primary_10_1007_s00592_021_01740_8
crossref_primary_10_1016_j_jash_2015_08_002
crossref_primary_10_1016_j_semnephrol_2014_08_011
crossref_primary_10_1097_HJH_0b013e3283614648
crossref_primary_10_3389_fcvm_2021_691513
Cites_doi 10.1177/0962280206077743
10.1016/S0022-1759(00)00156-3
10.1038/ki.1995.22
10.1056/NEJMcp042317
10.1016/j.jacc.2005.09.032
10.1056/NEJMoa041365
10.1056/NEJM199912023412303
10.1016/j.ijcard.2008.11.048
10.1038/ki.2009.169
10.1111/j.1523-1755.2004.00552.x
10.1067/mhj.2001.113218
10.1161/CIRCULATIONAHA.107.732032
10.1001/jama.290.2.215
10.1038/ki.1990.182
10.1097/MNH.0b013e3282f521ba
10.1161/CIRCULATIONAHA.104.526699
10.1016/j.amjcard.2008.06.036
10.1161/01.CIR.68.1.210
10.1016/S1387-2656(05)11004-7
10.1038/ki.1989.192
10.1016/j.amjcard.2007.01.041
10.1161/01.HYP.0000121881.77212.b1
10.1007/s00109-006-0151-4
10.1172/JCI24066
10.1056/NEJM199005313222203
10.1001/jama.298.11.1291
10.1016/j.amjcard.2006.05.039
10.1161/CIRCULATIONAHA.107.700401
10.1016/0002-8703(91)90586-7
10.1016/j.carrev.2006.01.004
10.1056/NEJMoa041031
10.1097/MNH.0b013e3281bd8877
10.1016/S0894-7317(89)80014-8
ContentType Journal Article
Copyright COPYRIGHT 2010 Public Library of Science
2010 Farzaneh-Far et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Farzaneh-Far et al. 2010
Copyright_xml – notice: COPYRIGHT 2010 Public Library of Science
– notice: 2010 Farzaneh-Far et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Farzaneh-Far et al. 2010
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AEUYN
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PTHSS
PYCSY
RC3
7X8
5PM
DOA
DOI 10.1371/journal.pone.0013496
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
ProQuest Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database (subscription)
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Materials Science & Engineering
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agricultural Science Database
ProQuest Health & Medical Collection
Medical Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database (subscription)
Nursing & Allied Health Premium
AAdvanced Technologies & Aerospace Database (subscription)
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database (subscripiton)
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Engineering collection
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList


Agricultural Science Database
MEDLINE

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Medicine
DocumentTitleAlternate Renalase
EISSN 1932-6203
ExternalDocumentID 1292302517
oai_doaj_org_article_e223eb51fe37498d8d65c397b9401972
PMC2958117
2898125571
A473843616
20975995
10_1371_journal_pone_0013496
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GeographicLocations United States--US
San Francisco Bay
California
GeographicLocations_xml – name: San Francisco Bay
– name: United States--US
– name: California
GrantInformation_xml – fundername: NHLBI NIH HHS
  grantid: R01 HL079235
GroupedDBID ---
123
29O
2WC
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
ADRAZ
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
EMOBN
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IGS
IHR
IHW
INH
INR
IOV
IPNFZ
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
O5R
O5S
OK1
OVT
P2P
P62
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PYCSY
RIG
RNS
RPM
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
3V.
BBORY
CGR
CUY
CVF
ECM
EIF
NPM
PMFND
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
RC3
7X8
5PM
PUEGO
-
02
AAPBV
ABPTK
ADACO
BBAFP
KM
ID FETCH-LOGICAL-c592t-9ff1611cabbc7804ca42a8fc8918f50109665c2365c5a2d27e03ca168743ae533
IEDL.DBID M48
ISSN 1932-6203
IngestDate Fri Nov 26 17:13:10 EST 2021
Wed Aug 27 01:26:26 EDT 2025
Thu Aug 21 14:20:57 EDT 2025
Thu Jul 10 21:53:22 EDT 2025
Fri Jul 25 10:26:36 EDT 2025
Tue Jun 17 21:32:03 EDT 2025
Tue Jun 10 20:50:45 EDT 2025
Wed Feb 19 02:04:36 EST 2025
Tue Jul 01 01:44:12 EDT 2025
Thu Apr 24 22:59:47 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c592t-9ff1611cabbc7804ca42a8fc8918f50109665c2365c5a2d27e03ca168743ae533
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Conceived and designed the experiments: RFF GD MAW. Performed the experiments: RFF GD NS MAW. Analyzed the data: RFF GD BN NS MAW. Contributed reagents/materials/analysis tools: GD MAW. Wrote the paper: RFF.
OpenAccessLink https://doaj.org/article/e223eb51fe37498d8d65c397b9401972
PMID 20975995
PQID 1292302517
PQPubID 1436336
ParticipantIDs plos_journals_1292302517
doaj_primary_oai_doaj_org_article_e223eb51fe37498d8d65c397b9401972
pubmedcentral_primary_oai_pubmedcentral_nih_gov_2958117
proquest_miscellaneous_760210172
proquest_journals_1292302517
gale_infotracmisc_A473843616
gale_infotracacademiconefile_A473843616
pubmed_primary_20975995
crossref_citationtrail_10_1371_journal_pone_0013496
crossref_primary_10_1371_journal_pone_0013496
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2010-10-20
PublicationDateYYYYMMDD 2010-10-20
PublicationDate_xml – month: 10
  year: 2010
  text: 2010-10-20
  day: 20
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, USA
PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2010
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References Q Zhao (ref13) 2007; 85
MV Berridge (ref20) 2005; 11
RA Wolfe (ref6) 1999; 341
GV Desir (ref12) 2009; 76
AS Levey (ref19) 1990; 38
WJ Remme (ref29) 1998; 19
RN Foley (ref26) 1995; 47
J Xu (ref9) 2007; 16
AS Go (ref2) 2004; 351
D Levy (ref23) 1990; 322
KL Lunetta (ref34) 2008; 118
J Abrams (ref33) 2005; 112
JS Silberberg (ref27) 1989; 36
BA Vakili (ref24) 2001; 141
SL Kopecky (ref31) 2006; 98
JA Joles (ref4) 2004; 43
GV Desir (ref10) 2008; 17
NS Anavekar (ref3) 2004; 351
J Neumann (ref5) 2004; 65
J Abrams (ref32) 2005; 352
BF Culleton (ref28) 2007; 298
J Xu (ref7) 2005; 115
MP Turakhia (ref25) 2008; 102
NB Schiller (ref16) 1983; 68
AS Tan (ref21) 2000; 238
GC Fonarow (ref30) 2006; 7
JK Oh (ref35) 2006; 47
WS Peart (ref1) 1977; 2
SS Ghosh (ref11) 2008
CK Morris (ref17) 1991; 122
V Didelez (ref22) 2007; 16
AJ Coats (ref36) 2009; 131
X Ren (ref15) 2007; 99
B Ruo (ref14) 2003; 290
NB Schiller (ref18) 1989; 2
G Li (ref8) 2008; 117
References_xml – volume: 16
  start-page: 309
  year: 2007
  ident: ref22
  article-title: Mendelian randomization as an instrumental variable approach to causal inference.
  publication-title: Stat Methods Med Res
  doi: 10.1177/0962280206077743
– volume: 238
  start-page: 59
  year: 2000
  ident: ref21
  article-title: Superoxide produced by activated neutrophils efficiently reduces the tetrazolium salt, WST-1 to produce a soluble formazan: a simple colorimetric assay for measuring respiratory burst activation and for screening anti-inflammatory agents.
  publication-title: J Immunol Methods
  doi: 10.1016/S0022-1759(00)00156-3
– volume: 47
  start-page: 186
  year: 1995
  ident: ref26
  article-title: Clinical and echocardiographic disease in patients starting end-stage renal disease therapy.
  publication-title: Kidney Int
  doi: 10.1038/ki.1995.22
– volume: 352
  start-page: 2524
  year: 2005
  ident: ref32
  article-title: Clinical practice. Chronic stable angina.
  publication-title: N Engl J Med
  doi: 10.1056/NEJMcp042317
– volume: 47
  start-page: 500
  year: 2006
  ident: ref35
  article-title: Diastolic heart failure can be diagnosed by comprehensive two-dimensional and Doppler echocardiography.
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2005.09.032
– volume: 2
  start-page: 543
  year: 1977
  ident: ref1
  article-title: The kidney as an endocrine organ.
  publication-title: Lancet
– volume: 351
  start-page: 1285
  year: 2004
  ident: ref3
  article-title: Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction.
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa041365
– volume: 341
  start-page: 1725
  year: 1999
  ident: ref6
  article-title: Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant.
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199912023412303
– volume: 131
  start-page: 149
  year: 2009
  ident: ref36
  article-title: Ethical authorship and publishing.
  publication-title: Int J Cardiol
  doi: 10.1016/j.ijcard.2008.11.048
– volume: 76
  start-page: 366
  year: 2009
  ident: ref12
  article-title: Regulation of blood pressure and cardiovascular function by renalase.
  publication-title: Kidney Int
  doi: 10.1038/ki.2009.169
– volume: 65
  start-page: 1568
  year: 2004
  ident: ref5
  article-title: Sympathetic hyperactivity in chronic kidney disease: pathogenesis, clinical relevance, and treatment.
  publication-title: Kidney Int
  doi: 10.1111/j.1523-1755.2004.00552.x
– volume: 141
  start-page: 334
  year: 2001
  ident: ref24
  article-title: Prognostic implications of left ventricular hypertrophy.
  publication-title: Am Heart J
  doi: 10.1067/mhj.2001.113218
– volume: 19
  start-page: F62
  year: 1998
  ident: ref29
  article-title: The sympathetic nervous system and ischaemic heart disease.
  publication-title: Eur Heart J
– volume: 117
  start-page: 1277
  year: 2008
  ident: ref8
  article-title: Catecholamines regulate the activity, secretion, and synthesis of renalase.
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.107.732032
– volume: 290
  start-page: 215
  year: 2003
  ident: ref14
  article-title: Depressive symptoms and health-related quality of life: the Heart and Soul Study.
  publication-title: JAMA
  doi: 10.1001/jama.290.2.215
– volume: 38
  start-page: 167
  year: 1990
  ident: ref19
  article-title: Measurement of renal function in chronic renal disease.
  publication-title: Kidney Int
  doi: 10.1038/ki.1990.182
– volume: 17
  start-page: 181
  year: 2008
  ident: ref10
  article-title: Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease.
  publication-title: Curr Opin Nephrol Hypertens
  doi: 10.1097/MNH.0b013e3282f521ba
– volume: 112
  start-page: e255
  year: 2005
  ident: ref33
  article-title: Therapy of stable angina pectoris: the uncomplicated patient.
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.104.526699
– volume: 102
  start-page: 1131
  year: 2008
  ident: ref25
  article-title: Prognostic significance of increased left ventricular mass index to mortality and sudden death in patients with stable coronary heart disease (from the Heart and Soul Study).
  publication-title: Am J Cardiol
  doi: 10.1016/j.amjcard.2008.06.036
– volume: 68
  start-page: 210
  year: 1983
  ident: ref16
  article-title: Canine left ventricular mass estimation by two-dimensional echocardiography.
  publication-title: Circulation
  doi: 10.1161/01.CIR.68.1.210
– volume: 11
  start-page: 127
  year: 2005
  ident: ref20
  article-title: Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction.
  publication-title: Biotechnol Annu Rev
  doi: 10.1016/S1387-2656(05)11004-7
– volume: 36
  start-page: 286
  year: 1989
  ident: ref27
  article-title: Impact of left ventricular hypertrophy on survival in end-stage renal disease.
  publication-title: Kidney Int
  doi: 10.1038/ki.1989.192
– volume: 99
  start-page: 1643
  year: 2007
  ident: ref15
  article-title: Prevalence and prognosis of asymptomatic left ventricular diastolic dysfunction in ambulatory patients with coronary heart disease.
  publication-title: Am J Cardiol
  doi: 10.1016/j.amjcard.2007.01.041
– volume: 43
  start-page: 699
  year: 2004
  ident: ref4
  article-title: Causes and consequences of increased sympathetic activity in renal disease.
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000121881.77212.b1
– volume: 85
  start-page: 877
  year: 2007
  ident: ref13
  article-title: Renalase gene is a novel susceptibility gene for essential hypertension: a two-stage association study in northern Han Chinese population.
  publication-title: J Mol Med
  doi: 10.1007/s00109-006-0151-4
– volume: 115
  start-page: 1275
  year: 2005
  ident: ref7
  article-title: Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.
  publication-title: J Clin Invest
  doi: 10.1172/JCI24066
– volume: 322
  start-page: 1561
  year: 1990
  ident: ref23
  article-title: Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study.
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199005313222203
– volume: 298
  start-page: 1291
  year: 2007
  ident: ref28
  article-title: Effect of frequent nocturnal hemodialysis vs conventional hemodialysis on left ventricular mass and quality of life: a randomized controlled trial.
  publication-title: JAMA
  doi: 10.1001/jama.298.11.1291
– volume: 98
  start-page: 1115
  year: 2006
  ident: ref31
  article-title: Effect of beta blockers, particularly carvedilol, on reducing the risk of events after acute myocardial infarction.
  publication-title: Am J Cardiol
  doi: 10.1016/j.amjcard.2006.05.039
– volume: 118
  start-page: 96
  year: 2008
  ident: ref34
  article-title: Genetic association studies.
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.107.700401
– volume: 122
  start-page: 1423
  year: 1991
  ident: ref17
  article-title: The prognostic value of exercise capacity: a review of the literature.
  publication-title: Am Heart J
  doi: 10.1016/0002-8703(91)90586-7
– volume: 7
  start-page: 1
  year: 2006
  ident: ref30
  article-title: Beta-blockers for the post-myocardial infarction patient: current clinical evidence and practical considerations.
  publication-title: Rev Cardiovasc Med
  doi: 10.1016/j.carrev.2006.01.004
– volume: 351
  start-page: 1296
  year: 2004
  ident: ref2
  article-title: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa041031
– volume: 16
  start-page: 373
  year: 2007
  ident: ref9
  article-title: Renalase, a new renal hormone: its role in health and disease.
  publication-title: Curr Opin Nephrol Hypertens
  doi: 10.1097/MNH.0b013e3281bd8877
– year: 2008
  ident: ref11
  article-title: Cardiac hypertrophy in neonatal nephrectomized rats: the role of the sympathetic nervous system.
  publication-title: Pediatr Nephrol
– volume: 2
  start-page: 358
  year: 1989
  ident: ref18
  article-title: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms.
  publication-title: J Am Soc Echocardiogr
  doi: 10.1016/S0894-7317(89)80014-8
SSID ssj0053866
Score 2.3112335
Snippet Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of...
Background Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding...
Background Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding...
SourceID plos
doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e13496
SubjectTerms Adenine
Aged
Amino acids
Angina pectoris
Aspartic Acid - chemistry
Authorship
Beta blockers
Cardiomegaly - genetics
Cardiovascular disease
Cardiovascular Disorders
Catecholamines
Clinical trials
Coronary artery
Coronary artery disease
Coronary heart disease
Coronary vessels
Deoxyribonucleic acid
DNA
Echocardiography
Enzymatic activity
Enzymes
Female
Flavin-adenine dinucleotide
Gene polymorphism
Genetic aspects
Genetic testing
Genetics and Genomics
Genotypes
Glutamic Acid - chemistry
Health risk assessment
Heart
Heart attacks
Heart diseases
Heart failure
Heart hypertrophy
Hemodialysis
Human subjects
Humans
Hypertrophy
Ischemia
Kidney diseases
Male
Medicine
Middle Aged
Monoamine Oxidase - chemistry
Monoamine Oxidase - genetics
Mortality
Myocardial Ischemia - genetics
NADH
Nephrology
Nervous system
Nicotinamide adenine dinucleotide
Patients
Polymorphism
Polymorphism, Single Nucleotide
Prospective Studies
Purines
Quality of life
R&D
Research & development
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Structure-function relationships
Ventricle
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBZlT72Upq9skxQdCm0gbiLJkuzctqUhFNpTA7kJWZbJgmubtffQP9Lf2xlZNnEJ5FIwe7AkWzsPzYw184mQ9yyteAFxQMIy5ZM0q9Kk4D5PrJI-5U6VSmPt8Pcf6vom_XYrb-8d9YU5YSM88Ei4cw_2yxeSVV7oNM_KrFTSgREtcogMch1WX7B5UzA1rsGgxUrFQjmh2Xnky6eubTzuPSBK-sIQBbz-eVVedXXbP-Ry_ps5ec8UXT0nz6IPSTfj3A_IE9-8IAdRS3v6MUJJn74kfzYUDdf4vY92bQ2RPhB22_-i24bufINVlB5G1HuhN313Src9tZFjvqT4lZa6IESO3kHIuht2LTDmjJa_--nJZ9Q2JQx0iD1gLykmnVIsW6HgXFI8MXsIPfp2X9MAZ_uK3Fx9_fnlOoknMSRO5nxI8qoCz5A5WxQOEYucTbnNKpflLKsk7q4p4AoX8CMtL7n2F8JZpjLwT6wHj_I1WTVA-0NCmbTM80I5BKbR0lqhZYWboUxUXOh8TcTEFuMiTDmellGbsPemIVwZqWyQmSYyc02SeVQ3wnQ80v8zcnzuiyDb4QaInomiZx4TvTX5gPJicCmAKTobKxrgPQiqZTapFlkqFIPXHS96ggq7RfMhStw0096AEwahIaLJwchJCh9upnMzPhQz5hrf7nujFUbzDGf5ZpTZ-c-CvmjEmVsTvZDmBTWWLc32LkCP81xiZfLb_0G-I_I0pGLAxS-OyWrY7f0JeHhD8S4o81-Ulk8O
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Public Health Database (subscription)
  dbid: 8C1
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1fi9QwEA-6gvgi3vnnVk_Jg6AHV2-TNEnri6x7LqtwIurBvZU0Tc-F2tZt9-G-iJ_XmW5arRwKpQ9N0qaZmWQmM_MLIc9ZmPMU7ICARcoFYZSHQcpdHBglXcitypTG3OGzj2p1Hn64kBd-w63xYZX9nNhN1FllcY_8BNYl0JYRYOtN_SPAU6PQu-qP0LhJbjGYgxE7P1oMIR4gy0r5dDmh2Ymnzqu6Kh16IBArfbQcdaj9w9w8qYuquU7x_Dt-8o8FaXmP3PWaJJ3vSL9Hbrhyn9w-877yfbLnxbahLz229NF98nNOl7CS7TYA6aeqANMfRnrdfKfrkn52JaZVOmhRbIWeN_URfd_QnoQuo7htSxcdV1m6Aht2024qoNQxPb1qcv_mY2rKDBpaBCMwr-mpaQ3FPBYK2iZdgWy1XY0v1bagGMh49YCcL999XawCfzRDYGXM2yDOc1AVmTVpahHCyJqQmyi3UcyiXKK7TSlpuYCbNDzj2s2ENUxFoLAYByrmQzIpgQwHhDJpmOOpsohUo6UxQsscvaNM5FzoeEpET6HEetxyPD6jSDpnnAb7ZTfgCdI18XSdkmBoVe9wO_5T_y0Sf6iLqNvdg2pzmXghThzoUi6VLHdCh3GURRn8Hyh0aQxWaqz5lLxA1klwboAuWuNTHOA7iLKVzEMtolAoBp87HNUEmbaj4gNkvr6nTfKb-6Flz5DXF9OhGF-KIXSlq7ZNohWa9wx7-WjHvsPP8lmsEXhuSvSIsUejMS4p1986LHIeS0xVfvzvXj0hd7qoC7j47JBM2s3WPQVlrk2fdRL7C4TgSLQ
  priority: 102
  providerName: ProQuest
Title A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study
URI https://www.ncbi.nlm.nih.gov/pubmed/20975995
https://www.proquest.com/docview/1292302517
https://www.proquest.com/docview/760210172
https://pubmed.ncbi.nlm.nih.gov/PMC2958117
https://doaj.org/article/e223eb51fe37498d8d65c397b9401972
http://dx.doi.org/10.1371/journal.pone.0013496
Volume 5
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1fb9MwELe27oUXxPi3wqj8gARIy1Q7sZ0gIdR1KwVp0zSotLfIcRyo1CWlSSX6GfjS3LlJRFABqfJDbSe27y6-8_l-R8hLFmQ8ATvAY6G0XhBmgZdwG3laChtwI1OpMHb48kpOZ8GnW3G7R5qcrfUCljtNO8wnNVstTn9837wHgX_nsjYo1nQ6XRa5Rc8CYqDvkwPYmxQmc7gMWr8CSLfzXqLW4kk-9Otgur89pbNZOUz_9svdWy6Kcpda-uftyt-2q8kDcr_WM-loyxiHZM_mD8lhLcklfV3DTb95RH6O6AQ2t-2ZIL0uFpu7AhZ_Xt7ReU5vbI6RlpZ-LGlDSptSPL6lY8ddhk7Bll1VqwIodkLPN2VWP-6E6jyFjgZBCfRbeq4rTTGehYLWSacgY5Vr8blYLyheaNw8JrPJxZfx1KtTNHhGRLzyoiwDlZEZnSQGoYyMDrgOMxNGLMwEut2kFIb7UAjNU67s0DeayRAUF21B1XxCejks-BGhTGhmeSINItYoobWvRIZeUuZn3FdRn_gNLWJT45djGo1F7JxyCuyY7dLGSMG4pmCfeG2v5Ra_4z_tz5DMbVtE33Z_FKuvcS3MsQWdyiaCZdZXQRSmYQrzA8UuicBajRTvk1fIJDFyLQzR6DrUAd6DaFvxKFB-GPiSweuOOy1Btk2n-gjZrBlpGYN2BjYjwsxBz4b1dlfTthofilfpclusy1hJNPMZjvLpllHbyfJhpBCArk9Uh4U7q9GtyeffHCY5jwSGLD_793yek3vu9gX8-PCY9KrV2r4Apa5KBmRf3SoowzHDcvJhQA7OLq6ubwbumGTg5PgXahVPJg
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwELemIgEviI0_KwzwAwgmLayxYztBQqi0VC1bJwSbtLfgOA5U6pLSpEL9InwMPiN3-QdFEzxNqvpQ242T--Xu7Lv7mZCnrpewCNYBjutL63h-4jkRs4GjpbAeMzKWCmuHpydyfOa9PxfnW-RnUwuDaZWNTiwVdZwZ3CM_BLsE3jISbL1ZfHPw1CiMrjZHaFSwOLLr77Bky19PhiDfZ4yN3p0Oxk59qoBjRMAKJ0gS8HJco6PIIPuO0R7TfmL8wPUTgZEiKYVhHL6EZjFTtseNdqUPtlZbgRugoPKveZwr5Or3B21KCegOKevyPK7cwxoNLxdZajHigdzsG-avPCWgtQWdxTzLL3N0_87X_MMAjm6TW7XnSvsV1LbJlk13yPVpHZvfIdu1msjpi5rLev8O-dGnI7Cc1YYj_ZDN1xcZSHaWX9BZSj_aFMs4LYyYr7jq54t9OslpAxkbU9wmpoMSxYaOYc28LJYZIOOADtd5Uv_zAdVpDAMNkh_oV3SoC02xboaCd0vHILSi7PEpW80pJk6u75KzKxHaPdJJQQy7hLpCu5ZF0iAzjhJacyUSjMa6PGFcBV3CGwmFpuZJx-M65mEZ_FOwXqoeeIhyDWu5donTjlpUPCH_6f8Whd_2RZbv8ods-SWslUZowXezkXATC1gL_NiP4f7AgYwCWBUHinXJc4ROiLoIpmh0XVIB10FWr7DvKe57XLpwub2NnqBDzEbzLoKvmWke_n7bYGQDyMubaduMf4ope6nNVnmoJG4nuDjL-xV825tlvUAh0V2XqA1gbzyNzZZ09rXkPmeBwNLoB_-e1RNyY3w6PQ6PJydHD8nNMuMDPqy3RzrFcmUfgSNZRI_Lt5eSz1etLn4BMieEmg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwELemIk28IDb-rDDADyCYtNDGTuwECaGyUrWMTRMwqW-Z4zhQqUtK0wr1i_Bh-HTcJU4gaIKnSVUeajtxcuf747v7mZCnrpeyGPwAxw2Ecbwg9ZyYmdBRwjce0yIREmuHT07F-Nx7P_WnW-RnXQuDaZW1TCwFdZJr3CPvgV4CaxkBtnqpTYs4G47eLL45eIIURlrr4zQqFjk2m-_gvhWvJ0Og9TPGRu8-H40de8KAo_2QrZwwTcHicbWKY41IPFp5TAWpDkI3SH2MGgnha8bh4iuWMGn6XCtXBKB3lfFxMxTE_w3JQW3CWpLTxtkDOSKELdXj0u1Zzni5yDOD0Q_EaW-pwvLEgEYvdBbzvLjK6P07d_MPZTi6TW5ZK5YOKrbbIVsm2yXbJzZOv0t2rMgo6AuLa31wh_wY0BFo0WrzkZ7l881lDlSeFZd0ltGPJsOSTgMj5msuB8XigE4KWrOPSShuGdOjkqM1HYP_vFwtc-CSQzrcFKm98yFVWQIDNQIhqFd0qFaKYg0NBUuXjoFoq7LHp3w9p5hEublLzq-FaPdIJwMy7BHq-so1LBYaUXKkrxSXfoqRWZenjMuwS3hNoUhbzHQ8umMelYFACb5T9cEjpGtk6dolTjNqUWGG_Kf_WyR-0xcRv8s_8uWXyAqQyIAdZ2LfTQ2XXhgkQQLvB8ZkHIKHHErWJc-RdSKUSzBFrWx5BTwHEb6igSd54HHhwuP2Wz1BnuhW8x4yXz3TIvq98mBkzZBXN9OmGW-K6XuZyddFJAVuLbg4y_sV-zYvy_qhRNC7LpEtxm59jXZLNvta4qCz0Mcy6Qf_ntUTsg2CIvowOT1-SG6WyR_wY_190lkt1-YR2JSr-HG5eCm5uG5p8QvNTIj8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Functional+Polymorphism+in+Renalase+Is+Associated+with+Cardiac+Hypertrophy%2C+Dysfunction%2C+and+Ischemia%3A+Data+from+the+Heart+and+Soul+Study&rft.jtitle=PloS+one&rft.au=Farzaneh-Far%2C+Ramin&rft.au=Desir%2C+Gary+V&rft.au=Na%2C+Beeya&rft.au=Schiller%2C+Nelson+B&rft.date=2010-10-20&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=5&rft.issue=10&rft.spage=e13496&rft_id=info:doi/10.1371%2Fjournal.pone.0013496&rft.externalDocID=A473843616
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon