Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery - Su, Fang-Yi; Lin, Kun-Ju; Sonaje, Kiran; Wey, Shiaw-Pyng; Yen, Tzu-Chen; Ho, Yi-Cheng; Panda, Nilendu; Chuang, Er-Yuan; Maiti, Barnali; Sung, Hsing-Wen (Biomaterials, 2012)
Keywords: absorption; Absorption - drug effects; Adherens junction; Administration, Oral; Advanced Basic Science; Animals; bioavailability; Biological Availability; biopharmaceuticals; bladder; blood glucose; Blood Glucose - drug effects; Cell Adhesion - drug effects; chitosan; Chitosan - chemical synthesis; Chitosan - chemistry; Complexing agent; confocal microscopy; Dentistry; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - pathology; Drug Delivery Systems - methods; Electric Impedance; enzyme inhibition; Injections, Subcutaneous; insulin; Insulin - administration & dosage; Insulin - blood; Insulin - pharmacokinetics; Insulin - pharmacology; kidneys; metal ions; mixing; Molecular dynamic simulation; Molecular Dynamics Simulation; nanoparticles; Nanoparticles - chemistry; Oral protein delivery; Particle Size; Pentetic Acid - chemistry; permeability; Polyglutamic Acid - chemical synthesis; Polyglutamic Acid - chemistry; Protease Inhibitors - pharmacology; Protective Agents - pharmacology; proteinases; Proteolytic inhibition; Rats; Rats, Wistar; scintigraphy; small intestine; Spectroscopy, Fourier Transform Infrared; Static Electricity; tight junctions; Tissue Distribution - drug effects; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Proteolytic inhibition; Oral protein delivery; Molecular dynamic simulation; Complexing agent; Adherens junction