Intestinal Villous M Cells: An Antigen Entry Site in the Mucosal Epithelium

M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut b...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 101; no. 16; pp. 6110 - 6115
Main Authors Jang, Myoung Ho, Kweon, Mi-Na, Iwatani, Koichi, Yamamoto, Masafumi, Terahara, Kazutaka, Sasakawa, Chihiro, Suzuki, Toshihiko, Nochi, Tomonori, Yokota, Yoshifumi, Rennert, Paul D., Hiroi, Takachika, Tamagawa, Hiroshi, Iijima, Hideki, Kunisawa, Jun, Yuki, Yoshikazu, Kiyono, Hiroshi, Curtiss, Roy
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 20.04.2004
National Acad Sciences
Subjects
Animals
Antigens
Antigens - immunology
B lymphocytes
Bacteria
Bacterial Adhesion
Biological Sciences
Cellular immunity
E coli
Epithelial cells
Epithelium
Gastrointestinal diseases
Immune system
Immunology
Intestinal Mucosa - cytology
Intestinal Mucosa - immunology
Intestinal Mucosa - microbiology
Intestinal Mucosa - ultrastructure
Intestines
Lymphocytes
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Electron
Peyer's Patches - immunology
Salmonella
Salmonella typhimurium - physiology
Small intestine
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Abstract M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin ( UEA)-1+ cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are developed in various PP [or gut-associated lymphoid tissue (GALT)]. null mice, such as in utero lymphotoxin β receptor (LTβR)-Ig-treated, lymphotoxin α ( LTα)-/-, tumor necrosis factor/ LTα -/-, and inhibition of differentiation 2( Id2)-/- mice. Intestinal villous M cells have been observed to take up GFP-expressing Salmonella, Yersinia, and Escherichia coli-expressing invasin, as well as gut bacterial antigen for subsequent induction of antigen-specific immune responses. Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment.
AbstractList M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin (UEA)-1 super(+) cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are developed in various PP [or gut-associated lymphoid tissue (GALT)]-null mice, such as in utero lymphotoxin beta receptor (LT beta R)-Ig-treated, lymphotoxin alpha (LT alpha ) super(-/-), tumor necrosis factor/LT alpha super(-/-), and inhibition of differentiation 2 (Id2) super(-/-) mice. Intestinal villous M cells have been observed to take up GFP-expressing Salmonella, Yersinia, and Escherichia coli-expressing invasin, as well as gut bacterial antigen for subsequent induction of antigen-specific immune responses. Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment.
M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin (UEA)-1(+) cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are developed in various PP [or gut-associated lymphoid tissue (GALT)]-null mice, such as in utero lymphotoxin beta receptor (LTbetaR)-Ig-treated, lymphotoxin alpha (LTalpha)(-/-), tumor necrosis factor/LTalpha(-/-), and inhibition of differentiation 2 (Id2)(-/-) mice. Intestinal villous M cells have been observed to take up GFP-expressing Salmonella, Yersinia, and Escherichia coli-expressing invasin, as well as gut bacterial antigen for subsequent induction of antigen-specific immune responses. Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment.
M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin (UEA)-1 + cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are developed in various PP [or gut-associated lymphoid tissue (GALT)]-null mice, such as in utero lymphotoxin β receptor (LTβR)-Ig-treated, lymphotoxin α (LTα) -/- , tumor necrosis factor/LTα -/- , and inhibition of differentiation 2 (Id2) -/- mice. Intestinal villous M cells have been observed to take up GFP-expressing Salmonella, Yersinia , and Escherichia coli -expressing invasin, as well as gut bacterial antigen for subsequent induction of antigen-specific immune responses. Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment.
M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin ( UEA)-1+ cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are developed in various PP [or gut-associated lymphoid tissue (GALT)]. null mice, such as in utero lymphotoxin β receptor (LTβR)-Ig-treated, lymphotoxin α ( LTα)-/-, tumor necrosis factor/ LTα -/-, and inhibition of differentiation 2( Id2)-/- mice. Intestinal villous M cells have been observed to take up GFP-expressing Salmonella, Yersinia, and Escherichia coli-expressing invasin, as well as gut bacterial antigen for subsequent induction of antigen-specific immune responses. Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment.
M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin (UEA)-1(+) cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are developed in various PP [or gut-associated lymphoid tissue (GALT)]-null mice, such as in utero lymphotoxin beta receptor (LTbetaR)-Ig-treated, lymphotoxin alpha (LTalpha)(-/-), tumor necrosis factor/LTalpha(-/-), and inhibition of differentiation 2 (Id2)(-/-) mice. Intestinal villous M cells have been observed to take up GFP-expressing Salmonella, Yersinia, and Escherichia coli-expressing invasin, as well as gut bacterial antigen for subsequent induction of antigen-specific immune responses. Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment.M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin (UEA)-1(+) cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are developed in various PP [or gut-associated lymphoid tissue (GALT)]-null mice, such as in utero lymphotoxin beta receptor (LTbetaR)-Ig-treated, lymphotoxin alpha (LTalpha)(-/-), tumor necrosis factor/LTalpha(-/-), and inhibition of differentiation 2 (Id2)(-/-) mice. Intestinal villous M cells have been observed to take up GFP-expressing Salmonella, Yersinia, and Escherichia coli-expressing invasin, as well as gut bacterial antigen for subsequent induction of antigen-specific immune responses. Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment.
M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin (UEA)-1+ cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are developed in various PP [or gut-associated lymphoid tissue (GALT)]-null mice, such as in utero lymphotoxin {beta} receptor (LT{beta}R)-Ig-treated, lymphotoxin {alpha} (LT{alpha})-/-, tumor necrosis factor/LT{alpha}-/-, and inhibition of differentiation 2 (Id2)-/- mice. Intestinal villous M cells have been observed to take up GFP-expressing Salmonella, Yersinia, and Escherichia coli-expressing invasin, as well as gut bacterial antigen for subsequent induction of antigen-specific immune responses. Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment. [PUBLICATION ABSTRACT]
Author Kweon, Mi-Na
Terahara, Kazutaka
Hiroi, Takachika
Rennert, Paul D.
Curtiss, Roy
Yokota, Yoshifumi
Yuki, Yoshikazu
Jang, Myoung Ho
Tamagawa, Hiroshi
Kiyono, Hiroshi
Nochi, Tomonori
Sasakawa, Chihiro
Suzuki, Toshihiko
Iwatani, Koichi
Yamamoto, Masafumi
Kunisawa, Jun
Iijima, Hideki
AuthorAffiliation a Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan; c Mucosal Immunology Section, International Vaccine Institute, Seoul 151-818, Korea; e Department of Oral Medicine, Nihon University, School of Dentistry at Matsudo, Chiba 271, Japan; g Division of Bacteriology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; h PRESTO (Precursory Research for Embryonic Science and Technology), Japan Science and Technology Corporation (JST), Kawaguchi, Saitama 332-0012, Japan; i First Department of Biochemistry, Fukui Medical University, Matsuoka, Fukui 910-1193, Japan; j Biogen Incorporated, Cambridge, MA 02142; f Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Kawaguchi, Saitama 332-0012, Japan; k Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294; and d Division of Mucosal Immunology, Institute of Medical Scie
AuthorAffiliation_xml – name: a Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan; c Mucosal Immunology Section, International Vaccine Institute, Seoul 151-818, Korea; e Department of Oral Medicine, Nihon University, School of Dentistry at Matsudo, Chiba 271, Japan; g Division of Bacteriology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; h PRESTO (Precursory Research for Embryonic Science and Technology), Japan Science and Technology Corporation (JST), Kawaguchi, Saitama 332-0012, Japan; i First Department of Biochemistry, Fukui Medical University, Matsuoka, Fukui 910-1193, Japan; j Biogen Incorporated, Cambridge, MA 02142; f Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Kawaguchi, Saitama 332-0012, Japan; k Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294; and d Division of Mucosal Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
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  givenname: Myoung Ho
  surname: Jang
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  givenname: Toshihiko
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  fullname: Suzuki, Toshihiko
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  fullname: Curtiss, Roy
BackLink https://www.ncbi.nlm.nih.gov/pubmed/15071180$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/44593
10.4049/jimmunol.168.1.57
10.1126/science.277.5328.949
10.1128/IAI.66.3.1237-1243.1998
10.1093/intimm/8.1.23
10.1126/science.273.5280.1380
10.1038/86373
10.1007/978-1-4615-1941-6_50
10.1016/0092-8674(90)90099-Z
10.1096/fasebj.13.6.611
10.4049/jimmunol.162.2.821
10.1016/S0092-8674(00)80106-3
10.1126/science.286.5446.1965
10.1126/science.287.5457.1431
10.1126/science.6259737
10.1146/annurev.physiol.60.1.143
10.4049/jimmunol.164.10.5184
10.4049/jimmunol.160.5.2188
10.1099/00222615-44-4-285
10.1038/17812
10.4049/jimmunol.165.8.4329
10.1016/S0002-9440(10)65410-7
10.1016/0076-6879(94)36030-8
10.1128/iai.43.1.72-78.1984
10.1053/gast.2001.22476
10.1038/35098100
10.1146/annurev.cellbio.16.1.301
10.1006/smim.1999.0173
10.1016/S0016-5085(77)80254-0
10.1084/jem.184.5.1999
10.1073/pnas.97.26.14650
10.1016/0264-410X(95)00198-A
10.1126/science.288.5474.2222
10.1126/science.8171322
10.1128/iai.57.3.858-863.1989
10.1073/pnas.86.16.6383
10.1084/jem.184.3.1045
10.1084/jem.180.1.15
10.1016/0092-8674(87)90335-7
10.1038/334522a0
10.1046/j.1462-5822.2000.00035.x
10.1002/(SICI)1096-9896(199611)180:3<326::AID-PATH656>3.0.CO;2-6
10.1053/gast.2000.16481
10.1128/iai.61.6.2585-2595.1993
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To whom correspondence should be addressed at the d address. E-mail: kiyono@ims.u-tokyo.ac.jp.
M.H.J. and M.-N.K. contributed equally to this work.
Abbreviations: PP, Peyer's patches; FAE, follicle-associated epithelium; LT, lymphotoxin; TNF, tumor necrosis factor; WGA, wheat germ agglutinin; UEA, Ulex europaeus agglutinin; TRITC, tetramethylrhodamine B isothiocyanate; IEC, intestinal epithelial cell; ILF, isolated lymphoid follicle; GALT, gut-associated lymphoid tissue; Id2, inhibition of differentiation 2.
Communicated by Roy Curtiss, Washington University, St. Louis, MO, February 11, 2004
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References e_1_3_2_26_2
e_1_3_2_27_2
e_1_3_2_29_2
e_1_3_2_41_2
e_1_3_2_40_2
e_1_3_2_20_2
e_1_3_2_43_2
e_1_3_2_21_2
e_1_3_2_42_2
e_1_3_2_22_2
e_1_3_2_45_2
e_1_3_2_23_2
e_1_3_2_44_2
e_1_3_2_24_2
e_1_3_2_47_2
e_1_3_2_25_2
e_1_3_2_46_2
e_1_3_2_9_2
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_8_2
e_1_3_2_16_2
e_1_3_2_37_2
e_1_3_2_7_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_18_2
(e_1_3_2_28_2) 1998; 160
e_1_3_2_39_2
e_1_3_2_19_2
e_1_3_2_1_2
(e_1_3_2_32_2) 1999; 79
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_5_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
e_1_3_2_12_2
(e_1_3_2_14_2) 1999; 162
e_1_3_2_33_2
e_1_3_2_3_2
e_1_3_2_13_2
e_1_3_2_36_2
e_1_3_2_2_2
e_1_3_2_35_2
(e_1_3_2_30_2) 1992; 10
11675788 - Nature. 2001 Oct 11;413(6856):639-43
8500896 - Infect Immun. 1993 Jun;61(6):2585-95
9252325 - Science. 1997 Aug 15;277(5328):949-52
11121065 - Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14650-5
8525916 - Adv Exp Med Biol. 1995;371A:239-41
3043229 - Nature. 1988 Aug 11;334(6182):522-4
8671586 - Int Immunol. 1996 Jan;8(1):23-36
9064322 - J Exp Med. 1996 Sep 1;184(3):1045-59
10799877 - J Immunol. 2000 May 15;164(10):5184-91
11266381 - Gastroenterology. 2001 Apr;120(5):1173-82
11276208 - Nat Immunol. 2001 Apr;2(4):361-7
10864873 - Science. 2000 Jun 23;288(5474):2222-6
9916704 - J Immunol. 1999 Jan 15;162(2):821-8
8735550 - Vaccine. 1996 Apr;14(5):392-8
10067894 - Nature. 1999 Feb 25;397(6721):702-6
9558458 - Annu Rev Physiol. 1998;60:143-59
8006579 - J Exp Med. 1994 Jul 1;180(1):15-23
8958813 - J Pathol. 1996 Nov;180(3):326-32
2645214 - Infect Immun. 1989 Mar;57(3):858-63
10381863 - Semin Immunol. 1999 Jun;11(3):171-81
10329609 - Am J Pathol. 1999 May;154(5):1573-82
1368983 - Biotechnology (N Y). 1992 Aug;10(8):888-92
832793 - Gastroenterology. 1977 Mar;72(3):440-51
6317574 - Infect Immun. 1984 Jan;43(1):72-8
2548211 - Proc Natl Acad Sci U S A. 1989 Aug;86(16):6383-7
8703071 - Science. 1996 Sep 6;273(5280):1380-3
9488419 - Infect Immun. 1998 Mar;66(3):1237-43
10548107 - Nature. 1999 Oct 21;401(6755):804-8
11031239 - Annu Rev Cell Dev Biol. 2000;16:301-32
8606357 - J Med Microbiol. 1996 Apr;44(4):285-94
11751946 - J Immunol. 2002 Jan 1;168(1):57-64
7968625 - Methods Enzymol. 1994;236:405-20
9498757 - J Immunol. 1998 Mar 1;160(5):2188-96
11207563 - Cell Microbiol. 2000 Feb;2(1):59-68
6259737 - Science. 1981 Apr 24;212(4493):471-2
10576210 - Lab Invest. 1999 Nov;79(11):1393-401
10982768 - Gastroenterology. 2000 Sep;119(3):734-43
10583962 - Science. 1999 Dec 3;286(5446):1965-8
11035068 - J Immunol. 2000 Oct 15;165(8):4329-37
3304658 - Cell. 1987 Aug 28;50(5):769-78
10688782 - Science. 2000 Feb 25;287(5457):1431-3
2311122 - Cell. 1990 Mar 9;60(5):861-71
10094922 - FASEB J. 1999 Apr;13(6):611-9
8756716 - Cell. 1996 Aug 9;86(3):345-8
8920886 - J Exp Med. 1996 Nov 1;184(5):1999-2006
8171322 - Science. 1994 Apr 29;264(5159):703-7
References_xml – ident: e_1_3_2_18_2
  doi: 10.1038/44593
– ident: e_1_3_2_47_2
  doi: 10.4049/jimmunol.168.1.57
– ident: e_1_3_2_9_2
  doi: 10.1126/science.277.5328.949
– volume: 10
  start-page: 888
  year: 1992
  ident: e_1_3_2_30_2
  publication-title: Biotechnology (N.Y.)
– ident: e_1_3_2_44_2
  doi: 10.1128/IAI.66.3.1237-1243.1998
– ident: e_1_3_2_20_2
  doi: 10.1093/intimm/8.1.23
– ident: e_1_3_2_33_2
  doi: 10.1126/science.273.5280.1380
– ident: e_1_3_2_19_2
  doi: 10.1038/86373
– ident: e_1_3_2_8_2
  doi: 10.1007/978-1-4615-1941-6_50
– ident: e_1_3_2_45_2
  doi: 10.1016/0092-8674(90)90099-Z
– ident: e_1_3_2_35_2
  doi: 10.1096/fasebj.13.6.611
– volume: 162
  start-page: 821
  year: 1999
  ident: e_1_3_2_14_2
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.162.2.821
– ident: e_1_3_2_4_2
  doi: 10.1016/S0092-8674(00)80106-3
– ident: e_1_3_2_10_2
  doi: 10.1126/science.286.5446.1965
– ident: e_1_3_2_37_2
  doi: 10.1126/science.287.5457.1431
– ident: e_1_3_2_40_2
  doi: 10.1126/science.6259737
– ident: e_1_3_2_1_2
  doi: 10.1146/annurev.physiol.60.1.143
– ident: e_1_3_2_17_2
  doi: 10.4049/jimmunol.164.10.5184
– volume: 160
  start-page: 2188
  year: 1998
  ident: e_1_3_2_28_2
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.160.5.2188
– ident: e_1_3_2_42_2
  doi: 10.1099/00222615-44-4-285
– ident: e_1_3_2_7_2
– ident: e_1_3_2_22_2
  doi: 10.1038/17812
– ident: e_1_3_2_15_2
  doi: 10.4049/jimmunol.165.8.4329
– ident: e_1_3_2_23_2
  doi: 10.1016/S0002-9440(10)65410-7
– ident: e_1_3_2_29_2
  doi: 10.1016/0076-6879(94)36030-8
– volume: 79
  start-page: 1393
  year: 1999
  ident: e_1_3_2_32_2
  publication-title: Lab. Invest.
– ident: e_1_3_2_26_2
  doi: 10.1128/iai.43.1.72-78.1984
– ident: e_1_3_2_11_2
  doi: 10.1053/gast.2001.22476
– ident: e_1_3_2_13_2
  doi: 10.1038/35098100
– ident: e_1_3_2_3_2
  doi: 10.1146/annurev.cellbio.16.1.301
– ident: e_1_3_2_5_2
  doi: 10.1006/smim.1999.0173
– ident: e_1_3_2_6_2
  doi: 10.1016/S0016-5085(77)80254-0
– ident: e_1_3_2_21_2
  doi: 10.1084/jem.184.5.1999
– ident: e_1_3_2_25_2
  doi: 10.1073/pnas.97.26.14650
– ident: e_1_3_2_12_2
  doi: 10.1016/0264-410X(95)00198-A
– ident: e_1_3_2_16_2
  doi: 10.1126/science.288.5474.2222
– ident: e_1_3_2_31_2
  doi: 10.1126/science.8171322
– ident: e_1_3_2_39_2
  doi: 10.1128/iai.57.3.858-863.1989
– ident: e_1_3_2_41_2
  doi: 10.1073/pnas.86.16.6383
– ident: e_1_3_2_2_2
  doi: 10.1084/jem.184.3.1045
– ident: e_1_3_2_38_2
  doi: 10.1084/jem.180.1.15
– ident: e_1_3_2_46_2
  doi: 10.1016/0092-8674(87)90335-7
– ident: e_1_3_2_27_2
  doi: 10.1038/334522a0
– ident: e_1_3_2_24_2
  doi: 10.1046/j.1462-5822.2000.00035.x
– ident: e_1_3_2_34_2
  doi: 10.1002/(SICI)1096-9896(199611)180:3<326::AID-PATH656>3.0.CO;2-6
– ident: e_1_3_2_36_2
  doi: 10.1053/gast.2000.16481
– ident: e_1_3_2_43_2
  doi: 10.1128/iai.61.6.2585-2595.1993
– reference: 10688782 - Science. 2000 Feb 25;287(5457):1431-3
– reference: 11675788 - Nature. 2001 Oct 11;413(6856):639-43
– reference: 8006579 - J Exp Med. 1994 Jul 1;180(1):15-23
– reference: 8958813 - J Pathol. 1996 Nov;180(3):326-32
– reference: 7968625 - Methods Enzymol. 1994;236:405-20
– reference: 10864873 - Science. 2000 Jun 23;288(5474):2222-6
– reference: 8606357 - J Med Microbiol. 1996 Apr;44(4):285-94
– reference: 10548107 - Nature. 1999 Oct 21;401(6755):804-8
– reference: 8735550 - Vaccine. 1996 Apr;14(5):392-8
– reference: 6259737 - Science. 1981 Apr 24;212(4493):471-2
– reference: 8671586 - Int Immunol. 1996 Jan;8(1):23-36
– reference: 10982768 - Gastroenterology. 2000 Sep;119(3):734-43
– reference: 10094922 - FASEB J. 1999 Apr;13(6):611-9
– reference: 11751946 - J Immunol. 2002 Jan 1;168(1):57-64
– reference: 9064322 - J Exp Med. 1996 Sep 1;184(3):1045-59
– reference: 3043229 - Nature. 1988 Aug 11;334(6182):522-4
– reference: 10381863 - Semin Immunol. 1999 Jun;11(3):171-81
– reference: 8756716 - Cell. 1996 Aug 9;86(3):345-8
– reference: 9916704 - J Immunol. 1999 Jan 15;162(2):821-8
– reference: 11266381 - Gastroenterology. 2001 Apr;120(5):1173-82
– reference: 2311122 - Cell. 1990 Mar 9;60(5):861-71
– reference: 6317574 - Infect Immun. 1984 Jan;43(1):72-8
– reference: 10799877 - J Immunol. 2000 May 15;164(10):5184-91
– reference: 11121065 - Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14650-5
– reference: 2548211 - Proc Natl Acad Sci U S A. 1989 Aug;86(16):6383-7
– reference: 10576210 - Lab Invest. 1999 Nov;79(11):1393-401
– reference: 10329609 - Am J Pathol. 1999 May;154(5):1573-82
– reference: 8703071 - Science. 1996 Sep 6;273(5280):1380-3
– reference: 9558458 - Annu Rev Physiol. 1998;60:143-59
– reference: 1368983 - Biotechnology (N Y). 1992 Aug;10(8):888-92
– reference: 10583962 - Science. 1999 Dec 3;286(5446):1965-8
– reference: 8525916 - Adv Exp Med Biol. 1995;371A:239-41
– reference: 9252325 - Science. 1997 Aug 15;277(5328):949-52
– reference: 11207563 - Cell Microbiol. 2000 Feb;2(1):59-68
– reference: 8920886 - J Exp Med. 1996 Nov 1;184(5):1999-2006
– reference: 2645214 - Infect Immun. 1989 Mar;57(3):858-63
– reference: 9488419 - Infect Immun. 1998 Mar;66(3):1237-43
– reference: 11035068 - J Immunol. 2000 Oct 15;165(8):4329-37
– reference: 10067894 - Nature. 1999 Feb 25;397(6721):702-6
– reference: 3304658 - Cell. 1987 Aug 28;50(5):769-78
– reference: 8500896 - Infect Immun. 1993 Jun;61(6):2585-95
– reference: 11276208 - Nat Immunol. 2001 Apr;2(4):361-7
– reference: 832793 - Gastroenterology. 1977 Mar;72(3):440-51
– reference: 9498757 - J Immunol. 1998 Mar 1;160(5):2188-96
– reference: 8171322 - Science. 1994 Apr 29;264(5159):703-7
– reference: 11031239 - Annu Rev Cell Dev Biol. 2000;16:301-32
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Snippet M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens....
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pubmed
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StartPage 6110
SubjectTerms Animals
Antigens
Antigens - immunology
B lymphocytes
Bacteria
Bacterial Adhesion
Biological Sciences
Cellular immunity
E coli
Epithelial cells
Epithelium
Gastrointestinal diseases
Immune system
Immunology
Intestinal Mucosa - cytology
Intestinal Mucosa - immunology
Intestinal Mucosa - microbiology
Intestinal Mucosa - ultrastructure
Intestines
Lymphocytes
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Electron
Peyer's Patches - immunology
Salmonella
Salmonella typhimurium - physiology
Small intestine
Title Intestinal Villous M Cells: An Antigen Entry Site in the Mucosal Epithelium
URI https://www.jstor.org/stable/3371972
http://www.pnas.org/content/101/16/6110.abstract
https://www.ncbi.nlm.nih.gov/pubmed/15071180
https://www.proquest.com/docview/201405115
https://www.proquest.com/docview/17949495
https://www.proquest.com/docview/71856377
https://pubmed.ncbi.nlm.nih.gov/PMC395931
Volume 101
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