Glutamate and Dysconnection in the Salience Network: Neurochemical, Effective Connectivity, and Computational Evidence in Schizophrenia

• Published in: Biological psychiatry (1969) Vol. 88; no. 3; pp. 273 - 281
• Main Authors: Limongi, Roberto, Jeon, Peter, Mackinley, Michael, Das, Tushar, Dempster, Kara, Théberge, Jean, Bartha, Robert, Wong, Dickson, Palaniyappan, Lena
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2020
• Subjects: Cerebral Cortex - diagnostic imaging; Dynamic causal models; Dysconnection hypothesis; Effective connectivity; Glutamate hypothesis; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Predictive coding; Psychiatric/Mental Health; Schizophrenia; Schizophrenia - diagnostic imaging; Predictive coding; Schizophrenia; Dysconnection hypothesis; Glutamate hypothesis; Dynamic causal models; Effective connectivity

Functional dysconnection in schizophrenia is underwritten by a pathophysiology of the glutamate neurotransmission that affects the excitation-inhibition balance in key nodes of the salience network. Physiologically, this manifests as aberrant effective connectivity in intrinsic connections involving...