Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s Disease

• Published in: PloS one Vol. 10; no. 11; p. e0142164
• Main Authors: Hasegawa, Satoru, Goto, Sae, Tsuji, Hirokazu, Okuno, Tatsuya, Asahara, Takashi, Nomoto, Koji, Shibata, Akihide, Fujisawa, Yoshiro, Minato, Tomomi, Okamoto, Akira, Ohno, Kinji, Hirayama, Masaaki
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.11.2015; Public Library of Science (PLoS)
• Subjects: Acute-Phase Proteins; Aged; Bacteria; Bacteria - genetics; Bacteroides fragilis; Cancer; Carrier Proteins - blood; Case-Control Studies; Clostridium; Colon; Constipation; Constipation - blood; Constipation - microbiology; DNA, Bacterial - genetics; Dysbacteriosis; Dysbiosis - blood; Dysbiosis - microbiology; E coli; Feces - microbiology; Female; Gene sequencing; Helicobacter pylori; Humans; Hydrogen; Intestinal Mucosa - microbiology; Intestine; Irritable bowel syndrome; Laboratories; Lactobacillus; Lipopolysaccharide-binding protein; Lipopolysaccharides; Male; Membrane Glycoproteins - blood; Membrane permeability; Metabolism; Metagenome - genetics; Microbiota; Movement disorders; Mucosa; Nervous system; Neurodegenerative diseases; Organs; Oxidative stress; Parkinson Disease - blood; Parkinson Disease - microbiology; Parkinson's disease; Parkinsons disease; Patients; Permeability; Polymerase chain reaction; Proteins; Regression analysis; Regression models; RNA, Ribosomal, 16S - genetics; rRNA 16S; rRNA 23S; Synuclein; University graduates; Womens health

The intestine is one of the first affected organs in Parkinson's disease (PD). PD subjects show abnormal staining for Escherichia coli and α-synuclein in the colon. We recruited 52 PD patients and 36 healthy cohabitants. We measured serum markers and quantified the numbers of 19 fecal bacterial...