Treatment of Type 2 Diabetes and Outcomes in Patients With Heart Failure: A Nested Case-Control Study From the U.K. General Practice Research Database

• Published in: Diabetes care Vol. 33; no. 6; pp. 1213 - 1218
• Main Authors: MacDonald, Michael R, Eurich, Dean T, Majumdar, Sumit R, Lewsey, James D, Bhagra, Sai, Jhund, Pardeep S, Petrie, Mark C, McMurray, John J.V, Petrie, John R, McAlister, Finlay A
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.2010
• Subjects: Adrenergic beta-Antagonists; Adrenergic beta-Antagonists - adverse effects; Adrenergic beta-Antagonists - therapeutic use; adverse effects; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Angiotensin-Converting Enzyme Inhibitors - adverse effects; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Aspirin; Aspirin - adverse effects; Aspirin - therapeutic use; beta-adrenergic antagonists; Biological and medical sciences; body mass index; Case-Control Studies; comorbidity; complications; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - mortality; Diabetes therapy; Diabetes. Impaired glucose tolerance; Digoxin; Digoxin - adverse effects; Digoxin - therapeutic use; Drug therapy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Family medicine; Female; glucose; Great Britain; Heart failure; Heart Failure - complications; Heart Failure - drug therapy; Heart Failure - mortality; Humans; Hypoglycemic Agents; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - therapeutic use; insulin; Male; Medical research; Medical sciences; Medicine; Medicine, Experimental; Metabolic diseases; metformin; Metformin - adverse effects; Metformin - therapeutic use; Miscellaneous; mortality; noninsulin-dependent diabetes mellitus; odds ratio; Online databases; Original Research; Patient outcomes; patients; Practice; Public health. Hygiene; Public health. Hygiene-occupational medicine; renal function; Studies; therapeutic use; Type 2 diabetes; United Kingdom; United Kingdom; Europe; Great Britain; Endocrinopathy; Type 2 diabetes; Human; Heart failure; Prognosis; Nutrition; Cardiovascular disease; Patient; Metabolic diseases; Case control study; Epidemiology; Treatment; Heart disease; Scientific research; Database; Evolution; General practice; Endocrinology; Public health

OBJECTIVE: Diabetes and heart failure commonly coexist, and prior studies have suggested better outcomes with metformin than other antidiabetic agents. We designed this study to determine whether this association reflects a beneficial effect of metformin or a harmful effect of other agents. RESEARCH...