Glycated and Oxidized Protein Degradation Products Are Indicators of Fasting and Postprandial Hyperglycemia in Diabetes

• Published in: Diabetes care Vol. 28; no. 10; pp. 2465 - 2471
• Main Authors: Ahmed, Naila, Babaei-Jadidi, Roya, Howell, Scott K, Thornalley, Paul J, Beisswenger, Paul J
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.10.2005
• Subjects: administration & dosage; Adult; analogs & derivatives; Biological and medical sciences; blood; blood glucose; Blood Glucose - metabolism; Cross-Over Studies; Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - metabolism; Diabetes. Impaired glucose tolerance; Diagnosis; Drug therapy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; excretion; Fasting; Female; glucose; Glycated Hemoglobin; Glycated Hemoglobin A - metabolism; glycation; Glycation End Products, Advanced - blood; Glycation End Products, Advanced - urine; Glycosylation End Products, Advanced; high performance liquid chromatography; Humans; Hyperglycemia; Hyperglycemia - drug therapy; Hyperglycemia - metabolism; Hypoglycemic Agents; Hypoglycemic Agents - administration & dosage; insulin; Insulin - administration & dosage; Insulin - analogs & derivatives; Insulin Lispro; insulin-dependent diabetes mellitus; Male; mass spectrometry; Medical sciences; metabolism; Middle Aged; Nitrogen; Nitrogen - metabolism; Oxidation-Reduction; Oxidative Stress; patients; Postprandial Period; protein degradation; Proteins; Proteolysis; Risk factors; therapeutics; urine; Endocrinopathy; Glycated protein; Hyperglycemia; Postprandial; Diabetes mellitus; Oxidation; Protein product; Fast; Degradation product; Indicator

OBJECTIVE:--To assess the relative importance of fasting and postprandial hyperglycemia to vascular dysfunction in diabetes, we have measured indicators of glycation, oxidative and nitrosative stress in subjects with type 1 diabetes, and different postprandial glucose patterns. RESEARCH DESIGN AND M...