Effects of Exercise Intensity on Spatial Memory Performance and Hippocampal Synaptic Plasticity in Transient Brain Ischemic Rats

• Published in: PloS one Vol. 8; no. 10; p. e78163
• Main Authors: Shih, Pei-Cheng, Yang, Yea-Ru, Wang, Ray-Yau
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.10.2013; Public Library of Science (PLoS)
• Subjects: Adaptive technology; Animal behavior; Animal memory; Animals; Blotting, Western; Brain; Brain Ischemia - metabolism; Brain Ischemia - physiopathology; Brain-derived neurotrophic factor; Cerebral blood flow; Cognitive ability; Corticosterone; Dendritic Spines - metabolism; Dendritic Spines - physiology; Dendritic structure; Enzyme-Linked Immunosorbent Assay; Exercise intensity; Fitness equipment; Group dynamics; Handicapped assistance devices; Hippocampal plasticity; Hippocampus; Hippocampus - cytology; Hippocampus - metabolism; Ischemia; Male; Memory - physiology; Memory tasks; Neuronal Plasticity - physiology; Neurons; Neurosciences; Occlusion; Physical Conditioning, Animal; Physical therapy; Physical training; Plasticity; Postsynaptic density; Postsynaptic density proteins; Proteins; Rats; Rats, Sprague-Dawley; Recovery of function; Retention; Rodents; Spatial analysis; Spatial memory; Stroke; Synapsin; Synapsin I; Synaptic plasticity; Training; Veins & arteries; Taiwan

Memory impairment is commonly noted in stroke survivors, and can lead to delay of functional recovery. Exercise has been proved to improve memory in adult healthy subjects. Such beneficial effects are often suggested to relate to hippocampal synaptic plasticity, which is important for memory process...